The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification

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The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1161/CIRCRESAHA.110.234245
P932PMC publication ID3128471
P698PubMed publication ID21659652

P50authorLinda L DemerQ42562196
P2093author name stringYin Tintut
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Osteopontin inhibits mineral deposition and promotes regression of ectopic calcificationQ24684936
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone developmentQ28119185
Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cellsQ28141829
Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survivalQ28142897
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RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesisQ28293009
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsQ29547605
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligandQ29619331
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Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesisQ36368706
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Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.Q36678487
Associations between oxidized LDL to LDL ratio, HDL and vascular calcification in the feet of hemodialysis patientsQ37078140
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Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of boneQ39116021
Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosisQ39124107
High-density lipoprotein regulates calcification of vascular cells.Q39265314
Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signalingQ39804721
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Do statins slow the progression of aortic valve stenosis?Q40102551
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cellsQ40243228
Bone morphogenetic protein expression in human atherosclerotic lesions.Q40304303
Role of oxidized low density lipoprotein in atherogenesisQ40343074
Expression and function of TNF-family proteins and receptors in human osteoblasts.Q40616037
Multilineage potential of cells from the artery wall.Q40622386
8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathwayQ40752751
Stimulation of bone formation in vitro and in rodents by statinsQ40914337
The missing boneQ41496768
Osteoclast markers accumulate on cells developing from human peripheral blood mononuclear precursorsQ41608135
Lowering plasma cholesterol levels halts progression of aortic valve disease in miceQ41946374
Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcificationQ42994159
Chondrocyte rather than osteoblast conversion of vascular cells underlies medial calcification in uremic ratsQ43044963
Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorptionQ43604722
Oxidative stress modulates osteoblastic differentiation of vascular and bone cellsQ43702897
Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D.Q43764592
TNF-related activation-induced cytokine (TRANCE) induces angiogenesis through the activation of Src and phospholipase C (PLC) in human endothelial cellsQ43821708
PTH differentially regulates expression of RANKL and OPG.Q43832667
Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular diseaseQ43865169
Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from boneQ43993807
Genome-wide expression analyses establish dendritic cells as a new osteoclast precursor able to generate bone-resorbing cells more efficiently than monocytesQ44159309
Osteopontin Deficiency Attenuates Atherosclerosis in Female Apolipoprotein E–Deficient MiceQ44429147
The predictive power of low-density lipoprotein cholesterol for coronary calcificationQ44575036
RANKL regulates endothelial cell survival through the phosphatidylinositol 3′‐kinase/Akt signal transduction pathwayQ44590687
Osteoprotegerin Regulates Bone Formation through a Coupling Mechanism with Bone ResorptionQ44590734
Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient miceQ44592811
Low bone density and abnormal bone turnover in patients with atherosclerosis of peripheral vessels.Q44683819
Relationship between lipids and bone mass in 2 cohorts of healthy women and men.Q44688641
Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivoQ44690058
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N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways.Q45935973
Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients.Q45946808
RANKL increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathwayQ46072800
Monocyte/macrophage regulation of vascular calcification in vitroQ46083654
Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly womenQ46130374
Pericytes derived from the retinal microvasculature undergo calcification in vitroQ46273892
Regulation of RANKL-induced osteoclastic differentiation by vascular cellsQ46283747
Atherogenic high-fat diet reduces bone mineralization in miceQ46289468
Lipid hypothesis of cardiovascular calcificationQ46292905
Chronic kidney disease bone and mineral disorder (CKD-MBD) in apolipoprotein E-deficient mice with chronic renal failure.Q46296691
Development of aortic valve sclerosis or stenosis in rabbits: role of cholesterol and calcium.Q46408797
Rationale for the role of osteoclast-like cells in arterial calcificationQ46559477
Genetic determination of cartilaginous metaplasia in mouse aorta.Q46608623
Oxidized low-density lipoprotein acts synergistically with beta-glycerophosphate to induce osteoblast differentiation in primary cultures of vascular smooth muscle cellsQ46608634
Non-HDL cholesterol is strongly associated with coronary artery calcification in asymptomatic individualsQ46614616
A novel in vivo role for osteoprotegerin ligand in activation of monocyte effector function and inflammatory responseQ46743257
Oxidant generation predominates around calcifying foci and enhances progression of aortic valve calcificationQ46830525
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivoQ46881126
Ectopic calcification of rat aortas and kidneys is reduced with n-3 fatty acid supplementationQ46937168
RANKL links arterial calcification with osteolysisQ47857745
Clonal endothelial cells produce humoral factors that inhibit osteoclast-like cell formation in vitroQ48459182
Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/- miceQ48900425
Chondrogenic and adipogenic potential of microvascular pericytes.Q50784818
Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2.Q51838900
Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis.Q52118613
Effect of simvastatin (80 mg) on coronary and abdominal aortic arterial calcium (from the coronary artery calcification treatment with zocor [CATZ] study).Q53477615
Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis.Q54074255
Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.Q54137269
Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorptionQ58085856
In vitro osteoclast generation from different bone marrow fractions, including a highly enriched haematopoietic stem cell populationQ59080212
Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometryQ59307017
Time course of oxysterol formation during in vitro oxidation of low density lipoproteinQ59307019
Abdominal aortic calcification on vertebral morphometry images predicts incident myocardial infarctionQ59587158
Observations on bone formation and remodelling in advanced atherosclerotic lesions of human carotid arteriesQ62056241
Decorin GAG synthesis and TGF-β signaling mediate Ox-LDL-induced mineralization of human vascular smooth muscle cellsQ64380010
Ultrastructural identification of monocyte-derived foam cells in fatty streak lesionsQ70718490
Matrix vesicles in atherosclerotic calcificationQ71671852
Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcificationQ73075489
Increased osteoprotegerin serum levels in men with coronary artery diseaseQ73106368
Low serum levels of soluble RANK ligand are associated with the presence of coronary artery disease in menQ73167301
Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathwayQ73209080
Increased levels of biochemical markers of bone turnover in relation to persistent immune activation in common variable immunodeficiencyQ73418675
Bone formation and inflammation in cardiac valvesQ73635711
Receptor activator of NF-kappa B and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesisQ73684776
Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal studyQ74152546
A single nucleotide polymorphism in the promoter region of the human gene for osteoprotegerin is related to vascular morphology and functionQ74259336
PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathwaysQ74308465
Osteoprotegerin: a link between osteoporosis and arterial calcification?Q74348478
Serum osteoprotegerin levels are associated with the presence and severity of coronary artery diseaseQ74711101
Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcificationQ75301236
Differential expression of bone matrix regulatory proteins in human atherosclerotic plaquesQ77350558
Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient miceQ77520948
P433issue12
P921main subjectatherosclerosisQ12252367
P304page(s)1482-1493
P577publication date2011-06-01
P1433published inCirculation ResearchQ2599020
P1476titleThe roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification
P478volume108

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cites work (P2860)
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