The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

scientific article

The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.201406120
P932PMC publication ID4332244
P698PubMed publication ID25666808
P5875ResearchGate publication ID272193089

P50authorWilliam A ComrieQ57511414
Janis K BurkhardtQ57586209
P2093author name stringShuixing Li
Sarah Boyle
P2860cites workHematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cellsQ24296902
A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulationQ84279859
Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.Q24300262
Mobility measurement by analysis of fluorescence photobleaching recovery kineticsQ24536888
Mechanical regulation of T-cell functionsQ27016079
Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondiiQ27316619
Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivityQ27333772
Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied ForcesQ27653293
Complete integrin headpiece opening in eight stepsQ27678790
The immunological synapse: a molecular machine controlling T cell activationQ28139151
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesinQ28208110
Three-dimensional segregation of supramolecular activation clusters in T cellsQ28282528
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapseQ28507578
Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cellsQ29391328
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin ActivationQ29617809
ERM proteins and merlin: integrators at the cell cortexQ29619893
CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapseQ30478206
RKIKK motif in the intracellular domain is critical for spatial and dynamic organization of ICAM-1: functional implication for the leukocyte adhesion and transmigrationQ30479484
SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motilityQ30488841
The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cellsQ30490766
Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch BondsQ30497295
F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activationQ30515819
Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC.Q30539566
F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse.Q30620661
A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interactionQ30654313
T cell receptor triggering by forceQ33348048
Outside-in signal transmission by conformational changes in integrin Mac-1Q33814332
Requirement of open headpiece conformation for activation of leukocyte integrin αXβ2Q34093237
Integrin inside-out signaling and the immunological synapseQ34237025
The membrane skeleton controls diffusion dynamics and signaling through the B cell receptorQ34322410
FRAP analysis of binding: proper and fittingQ34391528
Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2.Q35016499
An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response.Q35266959
Regulation of integrin affinity on cell surfacesQ35626360
Mechanosensing in T lymphocyte activationQ35679076
LFA-1 decreases the antigen dose for T cell activation in vivoQ57949054
Making a little affinity go a long way: a topological view of LFA-1 regulationQ57962349
Intercellular Adhesion Molecule-1-Dependent Stable Interactions between T Cells and Dendritic Cells Determine CD8+ T Cell MemoryQ58862007
Requirement of Rac1 and Rac2 Expression by Mature Dendritic Cells for T Cell PrimingQ58862030
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell primingQ61053878
Kinetics of T-cell receptor binding by bivalent HLA-DR. Peptide complexes that activate antigen-specific human T-cellsQ73316769
The dendritic cell cytoskeleton is critical for the formation of the immunological synapseQ73400715
Expression of the actin-bundling protein fascin in cultured human dendritic cells correlates with dendritic morphology and cell differentiationQ74347120
Two regions in the CD80 cytoplasmic tail regulate CD80 redistribution and T cell costimulationQ77319204
Cutting Edge: Dendritic Cell Actin Cytoskeletal Polarization during Immunological Synapse Formation Is Highly Antigen-DependentQ79186670
Naive B cells generate regulatory T cells in the presence of a mature immunologic synapseQ80058226
Cutting edge: rho activation and actin polarization are dependent on plexin-A1 in dendritic cellsQ80283959
T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76Q81445868
Dendritic cell microvilli: a novel membrane structure associated with the multifocal synapse and T-cell clusteringQ82017513
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.Q35739708
Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signalingQ36007725
Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunitQ36081222
Substrate rigidity regulates human T cell activation and proliferationQ36106477
Intracellular signalling controlling integrin activation in lymphocytesQ36167584
ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigrationQ36206453
Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesionQ36238215
In vivo priming of two distinct antitumor effector populations: the role of MHC class I expressionQ36362939
Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.Q36363402
Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1Q36378710
Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptorQ36401714
T cell-dendritic cell immunological synapsesQ36507797
Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actininQ36531816
Regulation of T-cell activation by the cytoskeletonQ36720943
The actin cytoskeleton in T cell activationQ37096089
Demonstration of catch bonds between an integrin and its ligand.Q37267611
Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarizationQ37403050
The alphabeta T cell receptor is an anisotropic mechanosensor.Q37431436
Diversity in immunological synapse structureQ37805565
The insider's guide to leukocyte integrin signalling and functionQ37877543
Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1).Q39396524
Cyclic mechanical reinforcement of integrin-ligand interactionsQ39540623
Intermediate monomer–dimer equilibrium structure of native ICAM-1: Implication for enhanced cell adhesionQ39642812
Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clusteringQ40244929
LFA-1-mediated costimulation of CD8+ T cell proliferation requires phosphatidylinositol 3-kinase activityQ40804976
Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activationQ40811225
Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunitsQ40822276
The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomersQ40831490
Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1.Q41277234
Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.Q41769969
LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathwaysQ41870070
Antigen-specific signaling by a soluble, dimeric peptide/major histocompatibility complex class II/Fc chimera leading to T helper cell type 2 differentiationQ41875914
TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell SignalingQ41910808
Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state.Q42812836
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrinsQ44590985
Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1.Q44607809
Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]Q46842083
Structural basis for dimerization of ICAM-1 on the cell surfaceQ47729587
Lack of ICAM-1 on APCs during T cell priming leads to poor generation of central memory cellsQ50088240
Morphological changes during dendritic cell maturation correlate with cofilin activation and translocation to the cell membrane.Q51030823
Evidence of a functional role for interaction between ICAM-1 and nonmuscle alpha-actinins in leukocyte diapedesis.Q51804250
LFA-1 contributes to signal I of T-cell activation and to the production of T(h)1 cytokines.Q52767106
Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling.Q54676899
Multifocal structure of the T cell - dendritic cell synapseQ56552634
Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elementsQ57228054
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
cell adhesionQ187640
dendritic cellQ506253
P304page(s)457-473
P577publication date2015-02-09
P1433published inJournal of Cell BiologyQ1524550
P1476titleThe dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility
P478volume208

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cites work (P2860)
Q64906300Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells.
Q50014323Actin works both sides of the immunological synapse
Q26751049Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse
Q92611061Activation and expansion of human T cells using artificial antigen-presenting cell scaffolds
Q58698089Adhesive Interactions Delineate the Topography of the Immune Synapse
Q50206686Analyzing Actin Dynamics at the Immunological Synapse.
Q38527819B Cells use Conserved Polarity Cues to Regulate Their Antigen Processing and Presentation Functions
Q26766483Biophysical Aspects of T Lymphocyte Activation at the Immune Synapse
Q92970937Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment
Q64133638Cellular protein profiles altered by PRRSV infection of porcine monocytes-derived dendritic cells
Q36296177Comprehensive Analysis of Immunological Synapse Phenotypes Using Supported Lipid Bilayers
Q26740099Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa Acquisita
Q42212744Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity
Q43813062Dynamic microtubules regulate cellular contractility during T-cell activation
Q89879757ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion
Q30620661F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse.
Q37400835Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse
Q97420779HMGB1/PI3K/Akt/mTOR Signaling Participates in the Pathological Process of Acute Lung Injury by Regulating the Maturation and Function of Dendritic Cells
Q49342250Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse
Q50131904Integrins in T Cell Physiology.
Q54207309LFA-1 in T Cell Migration and Differentiation.
Q36908674Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation
Q40236608Live-Cell Super-resolution Reveals F-Actin and Plasma Membrane Dynamics at the T Cell Synapse
Q39041826Mechanical Communication at the Immunological Synapse
Q92060011Mechanical Proofreading: A General Mechanism to Enhance the Fidelity of Information Transfer Between Cells
Q51817246Mechanical forces in the immune system.
Q53099215Mechanosensing in the immune response.
Q55481390Monocyte Response to Different Campylobacter jejuni Lysates Involves Endoplasmic Reticulum Stress and the Lysosomal⁻Mitochondrial Axis: When Cell Death Is Better Than Cell Survival.
Q98154429Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex
Q64054785Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse
Q90254861Powered and controlled T-cell production
Q38853772Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms
Q64100229Quantitative proteomic changes in LPS-activated monocyte-derived dendritic cells: A SWATH-MS study
Q59800862Role of Mechanotransduction and Tension in T Cell Function
Q55119821Sailing to and Docking at the Immune Synapse: Role of Tubulin Dynamics and Molecular Motors.
Q64891413Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells.
Q36976479Tapping out a mechanical code for T cell triggering
Q57072506The Actin Cytoskeleton: A Mechanical Intermediate for Signal Integration at the Immunological Synapse
Q26751046The Dendritic Cell Synapse: A Life Dedicated to T Cell Activation
Q36724456The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells
Q33602234WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts.
Q92482629mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse
Q89860594β2 Integrins-Multi-Functional Leukocyte Receptors in Health and Disease

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