Mechanical Communication at the Immunological Synapse

scientific article published on 13 December 2016

Mechanical Communication at the Immunological Synapse is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TCB.2016.10.005
P932PMC publication ID5367987
P698PubMed publication ID27986534

P2093author name stringMorgan Huse
Roshni Basu
P2860cites workRecruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formationQ24301158
Cell movement is guided by the rigidity of the substrateQ24537364
Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cellsQ24630734
The Dendritic Cell Synapse: A Life Dedicated to T Cell ActivationQ26751046
Mechanical regulation of T-cell functionsQ27016079
Controversy and consensus regarding myosin II function at the immunological synapseQ27021661
Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapseQ27026215
Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapseQ27320971
Force generation upon T cell receptor engagementQ27342631
Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based MotifQ27652912
Rho GTPases: biochemistry and biologyQ27860645
Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forcesQ28115946
The immunological synapse: a molecular machine controlling T cell activationQ28139151
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamicsQ29615714
Cells lying on a bed of microneedles: an approach to isolate mechanical forceQ29617095
Structural basis of integrin regulation and signalingQ29617618
Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1.Q30412646
E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretchQ30425577
Neutrophil morphology and migration are affected by substrate elasticityQ30489549
Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch BondsQ30497295
Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cellsQ30506037
B cells use mechanical energy to discriminate antigen affinitiesQ30541546
CD28 and CD3 have complementary roles in T-cell traction forcesQ30572013
DNA-based digital tension probes reveal integrin forces during early cell adhesion.Q30596242
Cytoskeletal forces during signaling activation in Jurkat T-cellsQ30620298
F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse.Q30620661
Integrins Form an Expanding Diffusional Barrier that Coordinates PhagocytosisQ30698911
Germinal center B cells recognize antigen through a specialized immune synapse architecture.Q30784700
Accumulation of serial forces on TCR and CD8 frequently applied by agonist antigenic peptides embedded in MHC molecules triggers calcium in T cellsQ33874701
Shouts, whispers and the kiss of death: directional secretion in T cellsQ34001889
CD4+ T-cell synapses involve multiple distinct stagesQ34031087
Early events in B cell activationQ34101385
Sensitive force technique to probe molecular adhesion and structural linkages at biological interfacesQ34129714
Stresses at the cell-to-substrate interface during locomotion of fibroblastsQ34170351
Osmotically induced membrane tension modulates membrane permeabilization by class L amphipathic helical peptides: nucleation model of defect formation.Q34176123
Germinal centersQ34245271
CD80 and CD86 differentially regulate mechanical interactions of T-cells with antigen-presenting dendritic cells and B-cellsQ34425289
The reaction-limited kinetics of membrane-to-surface adhesion and detachmentQ34560541
A DNA-based molecular probe for optically reporting cellular traction forcesQ34588696
Mechanically activated integrin switch controls alpha5beta1 functionQ34932810
The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobilityQ35094278
Importance of force linkage in mechanochemistry of adhesion receptors.Q35578469
Actin depletion initiates events leading to granule secretion at the immunological synapseQ35662889
Mechanosensing in T lymphocyte activationQ35679076
Integrins and T cell-mediated immunityQ35698435
Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion.Q35866215
Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cellsQ35884077
A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.Q35984263
The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold.Q36014751
Substrate rigidity regulates human T cell activation and proliferationQ36106477
Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells.Q36122457
Intracellular signalling controlling integrin activation in lymphocytesQ36167584
Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domainQ36320558
Deconstructing the form and function of the TCR/CD3 complexQ36394789
Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptidesQ36516117
Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell KillingQ36730697
Secretory mechanisms in cell-mediated cytotoxicityQ36824188
Defining single molecular forces required to activate integrin and notch signalingQ37010172
Demonstration of catch bonds between an integrin and its ligand.Q37267611
Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapseQ37322193
Genetic and cell biological analysis of integrin outside-in signaling.Q37400411
Understanding the structure and function of the immunological synapseQ37789101
Regulation of integrin activationQ37887794
Immune regulatory functions of DOCK family proteins in health and diseaseQ38126300
A Cholesterol-Based Allostery Model of T Cell Receptor PhosphorylationQ39756462
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesionQ40486037
Substrate stiffness regulates B-cell activation, proliferation, class switch, and T-cell-independent antibody responses in vivo.Q41440328
Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.Q41769969
B cell activation is regulated by the stiffness properties of the substrate presenting the antigens.Q44095803
Ligand recognition by alpha beta T cell receptorsQ46222293
Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosisQ46708974
Molecular mechanism of Peptide-induced pores in membranesQ49260601
Adhesion-dependent modulation of actin dynamics in Jurkat T cells.Q53301798
Centrosome polarization delivers secretory granules to the immunological synapse.Q53587934
The immunological synapse of CTL contains a secretory domain and membrane bridges.Q53676857
T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76Q81445868
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
P304page(s)241-254
P577publication date2016-12-13
P1433published inTrends in Cell BiologyQ1573994
P1476titleMechanical Communication at the Immunological Synapse
P478volume27

Reverse relations

cites work (P2860)
Q92290972A Ciliary View of the Immunological Synapse
Q64906300Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells.
Q64272930Advanced Materials and Devices for the Regulation and Study of NK Cells
Q83232153Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation
Q92846950Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk
Q39424290Cytoskeletal control of B cell responses to antigens
Q54207309LFA-1 in T Cell Migration and Differentiation.
Q90168597Mechanosensing through immunoreceptors
Q92480670Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell-target interactions
Q48529632Micropipette force probe to quantify single-cell force generation: application to T-cell activation
Q64054785Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse
Q47625174Receptor-mediated cell mechanosensing.
Q91811501Regulation of CD4+ T Cell Signaling and Immunological Synapse by Protein Tyrosine Phosphatases: Molecular Mechanisms in Autoimmunity
Q88779050Regulatory mechanisms in T cell receptor signalling
Q52668321Signals Controlling Lytic Granule Polarization at the Cytotoxic Immune Synapse.
Q93062570Spatial Lymphocyte Dynamics in Lymph Nodes Predicts the Cytotoxic T Cell Frequency Needed for HIV Infection Control
Q93054897Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy
Q64983658Visualizing Spatiotemporal Dynamics of Intercellular Mechanotransmission upon Wounding.
Q89860594β2 Integrins-Multi-Functional Leukocyte Receptors in Health and Disease

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