Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase

scholarly article

Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase is …
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scholarly articleQ13442814

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P819ADS bibcode2006PNAS..10316728C
P356DOI10.1073/PNAS.0604112103
P8608Fatcat IDrelease_quo4orgwfnh6datxpdcmhiwiwu
P932PMC publication ID1636523
P698PubMed publication ID17071746
P5875ResearchGate publication ID6724104

P50authorDaniel W UdwaryQ96816290
P2093author name stringCraig A Townsend
Blair C R Dancy
Jason M Crawford
Eric A Hill
P2860cites workGenome sequencing and analysis of Aspergillus oryzaeQ22122467
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis toolsQ24248165
Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulumQ24527376
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylaseQ27640455
The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase componentQ27730253
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
Biosynthetic Studies of Daunorubicin and Tetracenomycin CQ28202160
Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitroQ28215159
The calicheamicin gene cluster and its iterative type I enediyne PKSQ28218405
Structure and molecular organization of mammalian fatty acid synthaseQ28235053
The reaction of LipB, the octanoyl-[acyl carrier protein]:protein N-octanoyltransferase of lipoic acid synthesis, proceeds through an acyl-enzyme intermediateQ33229153
Putative polyketide synthase and laccase genes for biosynthesis of aurofusarin in Gibberella zeaeQ33754522
A new metabolic link. The acyl carrier protein of lipid synthesis donates lipoic acid to the pyruvate dehydrogenase complex in Escherichia coli and mitochondriaQ34064858
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functionsQ34316866
Polyketide biosynthesis: a millennium reviewQ34362914
Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthaseQ35592757
A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase.Q36104021
Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.Q36965969
Aspergillus has distinct fatty acid synthases for primary and secondary metabolismQ37055265
Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycinQ40697256
Evidence for a double-helical structure for modular polyketide synthases.Q40952312
Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosusQ42604712
Modular organization of genes required for complex polyketide biosynthesisQ42627871
4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acidQ43394722
Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulansQ43543858
Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transferQ44080804
Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex NorS in the biosynthesis of aflatoxin B(1).Q44152735
Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains.Q44283791
Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthaseQ46114155
Characterization of the interthiol acyltransferase reaction catalyzed by the beta-ketoacyl synthase domain of the animal fatty acid synthaseQ46190100
The CTB1 gene encoding a fungal polyketide synthase is required for cercosporin biosynthesis and fungal virulence of Cercospora nicotianaeQ46509263
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesisQ46668158
A polyketide synthase gene required for biosynthesis of the aflatoxin-like toxin, dothistromin.Q48090056
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraeaQ48248704
Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid synthases and a polyketide synthase in the biosynthesis of aflatoxin B1.Q52521222
The polyketide synthase gene pks4 from Gibberella fujikuroi encodes a key enzyme in the biosynthesis of the red pigment bikaverin.Q52548084
Biosynthesis of Erythromycin and Rapamycin.Q55035694
Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin BiosynthesisQ60480995
Complementation in vitro between purified mutant fatty acid synthetase complexes of yeastQ70159798
Enzymatic synthesis of 1,3,6,8-tetrahydroxynaphthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase PKS1Q74061867
Enzymology and Molecular Biology of Aflatoxin BiosynthesisQ77651491
Architecture of mammalian fatty acid synthase at 4.5 A resolutionQ82714902
Architecture of a fungal fatty acid synthase at 5 A resolutionQ82714907
P433issue45
P407language of work or nameEnglishQ1860
P304page(s)16728-16733
P577publication date2006-10-27
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleIdentification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase
P478volume103

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cites work (P2860)
Q37811894A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases.
Q34385351A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogen Parastagonospora nodorum
Q36609099A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae
Q35296323Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases
Q26863697Aflatoxin and deconstruction of type I, iterative polyketide synthase function
Q28828730Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis
Q57288669Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase
Q46337180Biochemical characterization of the minimal polyketide synthase domains in the lovastatin nonaketide synthase LovB.
Q51888672Biochemistry. Anatomy of a fungal polyketide synthase.
Q35637445Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains
Q42188930Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi perithecia
Q37063380Biosynthesis of sphinganine-analog mycotoxins
Q61450373Biosynthetic Gene Content of the 'Perfume Lichens' and
Q36488484Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis.
Q33768287Characterization of the Aspergillus nidulans monodictyphenone gene cluster.
Q28704556Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus
Q40934941Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase
Q92749804Chimeric 6-methylsalicylic acid synthase with domains of acyl carrier protein and methyltransferase from Pseudallescheria boydii shows novel biosynthetic activity
Q34003788Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains
Q42080622Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products
Q38592486Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase.
Q41884208Complexity generation in fungal polyketide biosynthesis: a spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin.
Q37872624Convergent strategies in biosynthesis
Q38064273Current understanding on aflatoxin biosynthesis and future perspective in reducing aflatoxin contamination
Q33910335Cyclization of aromatic polyketides from bacteria and fungi
Q40794040Deconstruction of iterative multidomain polyketide synthase function.
Q34341202Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase
Q36458956Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis.
Q92833467Docking analysis of hexanoic acid and quercetin with seven domains of polyketide synthase A provided insight into quercetin-mediated aflatoxin biosynthesis inhibition in Aspergillus flavus
Q48190463Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis
Q37081542Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli
Q36925570Engineering fungal nonreducing polyketide synthase by heterologous expression and domain swapping
Q35954467Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans
Q41996210Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi
Q40271160Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis
Q36115211Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products
Q38232921Fungal polyketide biosynthesis - a personal perspective
Q34434166Fungal polyketide synthase product chain-length control by partnering thiohydrolase
Q46052998Fungal type I polyketide synthases.
Q44466276Genetic localization and in vivo characterization of a Monascus azaphilone pigment biosynthetic gene cluster
Q34162270Genome-wide transcriptional profiling of appressorium development by the rice blast fungus Magnaporthe oryzae
Q37379780Heterologous expression systems for polyketide synthases
Q40388684Hidden function of catalytic domain in 6-methylsalicylic acid synthase for product release
Q21147075Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum
Q35977059Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans
Q34024374Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs
Q35906588Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity
Q34764381Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis
Q34170364Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum
Q41383383Navigating the fungal polyketide chemical space: from genes to molecules.
Q35235074New insights into the formation of fungal aromatic polyketides
Q28081722Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi
Q28473139Novel intermolecular iterative mechanism for biosynthesis of mycoketide catalyzed by a bimodular polyketide synthase.
Q41699486Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase
Q43240576Phylogenetic analysis of homologous fatty acid synthase and polyketide synthase involved in aflatoxin biosynthesis
Q33737908Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases
Q36104031Polyketide proofreading by an acyltransferase-like enzyme
Q39357904Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers.
Q34122684Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins
Q43087818Secondary metabolite profiling, growth profiles and other tools for species recognition and important Aspergillus mycotoxins.
Q35846863Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksA
Q35435897Starter unit specificity directs genome mining of polyketide synthase pathways in fungi
Q27657897Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization
Q33862817Structural enzymology of polyketide synthases
Q27660310Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis
Q37973514Synthetic biological approaches to natural product biosynthesis
Q26797354Synthetic biology of fungal natural products
Q35237614Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect".
Q40351270Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming.
Q56888762The architectures of iterative type I PKS and FAS
Q35435921The genome of the generalist plant pathogen Fusarium avenaceum is enriched with genes involved in redox, signaling and secondary metabolism
Q88249529The structural organization of substrate loading in iterative polyketide synthases
Q38038812The structural role of the carrier protein--active controller or passive carrier
Q38031740The structures of type I polyketide synthases
Q64988559Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi.

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