Molecular mechanisms underlying osteoclast formation and activation

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Molecular mechanisms underlying osteoclast formation and activation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0531-5565(03)00069-X
P698PubMed publication ID12814795
P5875ResearchGate publication ID10700823

P2093author name stringBruce R Troen
P2860cites workThe interaction of p62 with RIP links the atypical PKCs to NF-kappaB activationQ22009927
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
RANK is essential for osteoclast and lymph node developmentQ24598872
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand familiesQ28137631
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient miceQ28140546
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-SrcQ28142620
Expression and localization of estrogen receptor-beta in murine and human boneQ28144931
Estrogen resistance caused by a mutation in the estrogen-receptor gene in a manQ28248505
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiencyQ28284581
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptorQ28285539
A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosisQ28297820
Deflazacort increases osteoclast formation in mouse bone marrow culture and the ratio of RANKL/OPG mRNA expression in marrow stromal cellsQ28366694
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfonesQ28579975
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Estrogen modulation of osteoclast lysosomal enzyme secretionQ72259946
Specific binding of estrogen to osteoclast surfacesQ72412314
Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reactionQ73063008
Age-related decline in osteoprotegerin expression by human bone marrow cells cultured in three-dimensional collagen spongesQ73458768
Effects of age on serum dehydroepiandrosterone sulfate, IGF-I, and IL-6 levels in womenQ73815609
Tumor necrosis factor-alpha cooperates with receptor activator of nuclear factor kappaB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell cultureQ73853199
Sex steroids and boneQ74124341
Inhibition of bone resorption by 17beta-estradiol in human bone marrow culturesQ74276885
Accelerated turnover of metaphyseal trabecular bone in mice overexpressing cathepsin KQ74354073
Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cellsQ74520565
Sex steroids, mice, and men: when androgens and estrogens get very close to each otherQ77833163
Age-related changes in bone turnover in menQ77995353
Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op MiceQ28593712
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosisQ29619487
Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activationQ31717820
Osteoclasts secrete the chemotactic cytokine mim-1.Q31939533
Receptor activator of nuclear factor-kappa b ligand activates nuclear factor-kappa b in osteoclast precursorsQ31958046
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptorsQ32024958
Cathepsin K mRNA detection is restricted to osteoclasts during fetal mouse developmentQ32066782
A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and functionQ33542094
The actions and interactions of sex steroids and growth factors/cytokines on the skeletonQ33668744
Cell biology of the osteoclastQ33700885
Skeletal effects of estrogensQ33757719
Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis.Q33843319
Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopeniaQ33853506
Estrogen's bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cellsQ33854310
The effects of oestrogens on linear bone growthQ33949996
Involutional osteoporosisQ34181888
Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogensQ34368450
Effect of Testosterone and Estradiol in a Man with Aromatase DeficiencyQ34431437
A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men.Q34470260
Oestrogen, bones and men: when testosterone just isn't enough.Q34592284
Regulatory mechanisms of osteoblast and osteoclast differentiationQ34728971
Molecular genetics of too much boneQ34915198
Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repressionQ35169193
Human giant cell tumors of the bone (osteoclastomas) are estrogen target cellsQ35412006
Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cellsQ36230062
Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclastsQ36380532
Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD.Q36736233
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient miceQ36791739
Estrogen receptor specificity in the regulation of skeletal growth and maturation in male miceQ36978306
Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of boneQ37217673
Avian osteoclasts as estrogen target cellsQ37557847
Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions.Q38296222
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerinQ39116155
Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesisQ39714931
Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosisQ40565765
Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-kappaB ligand by osteoblastsQ40696407
IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo.Q40706159
Vector-averaged gravity regulates gene expression of receptor activator of NF-kappaB (RANK) ligand and osteoprotegerin in bone marrow stromal cells via cyclic AMP/protein kinase A pathwayQ40740093
A novel interaction between thyroid hormones and 1,25(OH)(2)D(3) in osteoclast formationQ40748154
Platelet-derived growth factor BB secreted from osteoclasts acts as an osteoblastogenesis inhibitory factorQ40754782
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signalingQ40756889
Regulation of osteoclast differentiation by fibroblast growth factor 2: stimulation of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor expression in osteoblasts and inhibition of macrophage colony-stimulating facQ40770110
Modulation of the effects of osteoprotegerin (OPG) ligand in a human leukemic cell line by OPG and calcitoninQ40837367
Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factorQ40838540
Cytokines and estrogen in bone: anti-osteoporotic effectsQ40900427
Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cellsQ40927574
Expression of estrogen receptor-alpha in cells of the osteoclastic lineageQ40965478
Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cellsQ41004339
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.Q41121255
Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factorQ42139985
In vitro secretion of cytokines by human bone marrow: effects of age and estrogen statusQ42456627
Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formationQ42475736
Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathwaysQ42494588
Effects of prostaglandin E2 on gene expression in primary osteoblastic cells from prostaglandin receptor knockout miceQ42519780
A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive functionQ42811314
Mechanical strain effect on bone-resorbing activity and messenger RNA expressions of marker enzymes in isolated osteoclast cultureQ43584322
Macrophage colony-stimulating factor suppresses osteoblast formationQ43667817
New insights into the regulation of cathepsin K gene expression by osteoprotegerin ligandQ43667822
Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouseQ43681246
Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primateQ43755553
Cathepsin K, osteoclastic resorption, and osteoporosis therapyQ43755557
Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL.Q43864464
Two different pathways for the maintenance of trabecular bone in adult male miceQ43936237
Osteoclastogenic potential of bone marrow cells increases with age in elderly women with fractureQ44151297
Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts.Q45713487
Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 miceQ46092958
Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo StudyQ46270750
The role of IL-6 type cytokines and their receptors in boneQ47966730
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.Q52192178
Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption.Q53897603
Osteoclasts isolated from membranous bone in children exhibit nuclear estrogen and progesterone receptors.Q54318356
Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not DemineralizationQ57272396
Tumor necrosis factor-α mediates polymethylmethacrylate particle-induced NF-κB activation in osteoclast precursor cellsQ58085449
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingQ58326943
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γQ59064307
Regulation of avian osteoclastic H+ -ATPase and bone resorption by tamoxifen and calmodulin antagonists. Effects independent of steroid receptorsQ71119891
Mammalian mature osteoclasts as estrogen target cellsQ71209943
Age-related bone loss in mice is associated with an increased osteoclast progenitor poolQ72045416
Osteoclast synthesis and secretion and activation of latent transforming growth factor betaQ72058811
P433issue6
P304page(s)605-614
P577publication date2003-06-01
P1433published inExperimental GerontologyQ15766996
P1476titleMolecular mechanisms underlying osteoclast formation and activation
P478volume38

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cites work (P2860)
Q46282244Abnormal differentiation of dental pulp cells in cleidocranial dysplasia
Q34426918Adseverin knockdown inhibits osteoclastogenesis in RAW264.7 cells
Q38711081Alpha-1 antitrypsin inhibits RANKL-induced osteoclast formation and functions
Q25257354An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology
Q34302274Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption
Q36021020Antiosteoporotic activity of phytoestrogen-rich fraction separated from ethanol extract of aerial parts of Cissus quadrangularis in ovariectomized rats
Q81217157Association of depressive symptoms with bone mineral density in older men: a population-based study
Q38995801BMP-2 and titanium particles synergistically activate osteoclast formation
Q37777066Biological Factors Involved in Implant-Anchored Orthodontics and in Prosthetic-Implant Therapy: A Literature Review
Q37982663Bisphosphonates: effects on osteoblast
Q34613578Breast cancer metastasis to the bone: mechanisms of bone loss
Q39533129Brief communication: the effects of disuse on the mechanical properties of bone: what unloading tells us about the adaptive nature of skeletal tissue
Q28505691CD109 plays a role in osteoclastogenesis
Q54641863Characterization of the cytokine pattern of porcine bone marrow-derived cells treated with 1alpha,25(OH)D.
Q51220391Cyclical tensile force on periodontal ligament cells inhibits osteoclastogenesis through OPG induction.
Q36610276Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice.
Q42776710Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting.
Q80149413Effect of rhBMP-2 and osteogenic revulsants on proliferation and differentiation of bone marrow stromal cells in rats
Q57779127Genetic Dissection of Human Stature in a Large Sample of Multiplex Pedigrees
Q37304461HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection
Q45419837Human cytomegalovirus, Epstein-Barr virus and bone resorption-inducing cytokines in periapical lesions of deciduous teeth
Q35129179Inflammation and uncoupling as mechanisms of periodontal bone loss
Q90087784Interleukin - 17 and Interleukin-10 as Inflammatory and Prevention Biomarkers in Periimplant Diseases
Q51627247Modeling of bone adaptative behavior based on cells activities.
Q91700438Myeloid-Derived Suppressor Cells at the Intersection of Inflammaging and Bone Fragility
Q47710981Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density.
Q39162234Osteoblasts subjected to mechanical strain inhibit osteoclastic differentiation and bone resorption in a co-culture system
Q64071144Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli
Q28261795Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro
Q38330138Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast
Q39305575Reflections about Osteoarthritis and Curcuma longa
Q39579627Retinoic acid inhibits NFATc1 expression and osteoclast differentiation
Q37714909Small molecules for bone diseases
Q39367467Storage media enhance osteoclastogenic potential of human periodontal ligament cells via RANKL-independent signaling.
Q37596611Targeting subchondral bone for treating osteoarthritis: what is the evidence?
Q36907683The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints
Q28251189The regulation of cathepsin K gene expression
Q81453343The role of dental pulp cells in resorption of deciduous teeth
Q43164216Upregulation of osteopontin by osteocytes deprived of mechanical loading or oxygen

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