Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling

scientific article published on 15 January 2002

Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M111696200
P698PubMed publication ID11792706
P5875ResearchGate publication ID11565433

P50authorMichael C. OstrowskiQ37379838
Uma SankarQ84357913
P2093author name stringJiahuai Han
Kim C Mansky
P2860cites workRegulation of the MEF2 family of transcription factors by p38Q22008562
Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factorsQ22010041
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiationQ24290523
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
A helix-loop-helix protein related to the immunoglobulin E box-binding proteinsQ24315939
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)Q24321919
Characterization of the structure and function of a novel MAP kinase kinase (MKK6)Q24336966
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple stepsQ24554203
RANK is essential for osteoclast and lymph node developmentQ24598872
TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activationQ24602693
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathwayQ24650627
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
The microphthalmia transcription factor regulates expression of the tartrate-resistant acid phosphatase gene during terminal differentiation of osteoclastsQ28140929
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-SrcQ28142620
Bone resorption by osteoclastsQ28145169
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsQ28237789
TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motifQ28284930
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptorQ28285539
The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamilyQ28291317
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factorQ28646220
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38deltaQ28646538
Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily membersQ30558730
Cell biology of the osteoclastQ33700885
MAP kinase pathways activated by stress: the p38 MAPK pathwayQ33916394
Linking osteopetrosis and pycnodysostosis: regulation of cathepsin K expression by the microphthalmia transcription factor familyQ34514934
Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repressionQ35169193
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinaseQ40924686
Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation.Q42826784
Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) miceQ43782638
Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper proteinQ44500763
The primary structure of p38 gamma: a new member of p38 group of MAP kinasesQ46763189
Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences.Q50522916
Evidence for the secretion of an osteoclast stimulating factor in myeloma.Q53791263
MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytesQ59096765
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)11077-11083
P577publication date2002-01-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleMicrophthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling
P478volume277

Reverse relations

cites work (P2860)
Q35831655(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression
Q35312616Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in an LXRβ-dependent mechanism
Q40212333Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB.
Q96954113An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling
Q35085783Anti-osteoclastogenic activity of matairesinol via suppression of p38/ERK-NFATc1 signaling axis
Q37191026Aspirin inhibits osteoclastogenesis by suppressing the activation of NF-κB and MAPKs in RANKL-induced RAW264.7 cells
Q60638027BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export
Q73200836Bad bones, grey hair, one mutation
Q33844646Baicalin positively regulates osteoclast function by activating MAPK/Mitf signalling
Q42473618Breast cancer cells with inhibition of p38alpha have decreased MMP-9 activity and exhibit decreased bone metastasis in mice
Q38967844CD271 is an imperfect marker for melanoma initiating cells.
Q33882828Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization
Q34473579Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation
Q42220685Class II and IV HDACs function as inhibitors of osteoclast differentiation
Q44751346Comparative Transcriptome and DNA methylation analyses of the molecular mechanisms underlying skin color variations in Crucian carp (Carassius carassius L.).
Q33779245Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice
Q35433533Deletion of histone deacetylase 7 in osteoclasts decreases bone mass in mice by interactions with MITF.
Q42160434Development of a chimaeric receptor approach to study signalling by tumour necrosis factor receptor family members
Q38347759Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts
Q39778248ERK-regulated differential expression of the Mitf 6a/b splicing isoforms in melanoma
Q55068550Endothelin-1 protects human melanocytes from UV-induced DNA damage by activating JNK and p38 signalling pathways.
Q92090606Enhanced Activation of Rac1/Cdc42 and MITF Leads to Augmented Osteoclastogenesis in Autosomal Dominant Osteopetrosis Type II
Q52331557Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation.
Q41842422Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors
Q24300916Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
Q47104550Ethyl linoleate inhibits α-MSH-induced melanogenesis through Akt/GSK3β/β-catenin signal pathway
Q52679967Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains.
Q36331194Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant.
Q38541335Focus on the p38 MAPK signaling pathway in bone development and maintenance
Q36881589Generating quiescent stem cells
Q38906998Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation
Q34752049HDAC3 and HDAC7 have opposite effects on osteoclast differentiation
Q54452122HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors.
Q37833524Histochemistry and cell biology: the annual review 2010.
Q35848573Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation
Q47322777Immunohistochemical evaluation of microphthalmia-associated transcription factor expression in giant cell lesions
Q48006799Involvement of upstream stimulatory factors 1 and 2 in RANKL-induced transcription of tartrate-resistant acid phosphatase gene during osteoclast differentiation
Q90306391MITF and UV responses in skin: From pigmentation to addiction
Q35187734MITF in melanoma: mechanisms behind its expression and activity.
Q92254234MITF-the first 25 years
Q53453283Malignant Melanoma With Osteoclast-Like Differentiation.
Q27024061Melanoma: from mutations to medicine
Q57307987Microarray analysis of changes in bone cell gene expression early after cadmium gavage in mice
Q53656611Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression.
Q38394400Microphthalmia-associated transcription factor in melanoma development and MAP-kinase pathway targeted therapy.
Q35071659Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors
Q33848784Mitf induction by RANKL is critical for osteoclastogenesis
Q34257775Mitf regulates osteoclastogenesis by modulating NFATc1 activity
Q26851553Modulation of osteoclast differentiation and bone resorption by Rho GTPases
Q37951952Molecular Network Associated with MITF in Skin Melanoma Development and Progression
Q37169549Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis
Q35157702Molecular mechanisms underlying osteoclast formation and activation
Q50701558OA10 is a novel p38alpha mitogen-activated protein kinase inhibitor that suppresses osteoclast differentiation and bone resorption.
Q35188522Obatoclax regulates the proliferation and fusion of osteoclast precursors through the inhibition of ERK activation by RANKL
Q92022414Osteoblasts contribute to a protective niche that supports melanoma cell proliferation and survival
Q29547556Osteoclast differentiation and activation
Q46960866Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL.
Q37036135Osteoclasts-Key Players in Skeletal Health and Disease
Q60928140Propofol promotes osteoclastic bone resorption by increasing DC-STAMP expression
Q38878942Proteomic approaches to study osteoclast biology
Q47256563RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1.
Q33820660Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor
Q64069924Regulation of Osteoclast Differentiation and Skeletal Maintenance by Histone Deacetylases
Q37868994Regulation of melanocyte pivotal transcription factor MITF by some other transcription factors
Q57056148Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology
Q52352323Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.
Q35577020Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations
Q35126799Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts
Q26766637Signaling Pathways in Osteoclast Differentiation
Q36082866Signaling networks that control the lineage commitment and differentiation of bone cells
Q34616432Stepping up melanocytes to the challenge of UV exposure
Q39957832Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK.
Q34166675Strength of TRAF6 signalling determines osteoclastogenesis
Q42370407Stress-induced haematopoietic stem cell proliferation: new roles for p38α and purine metabolism.
Q33847268Subcellular localization of Mitf in monocytic cells
Q34312986Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner
Q28118825Sumoylation of MITF and its related family members TFE3 and TFEB
Q33851600TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways
Q83061700Tacrolimus and cyclosporine A inhibit human osteoclast formation via targeting the calcineurin-dependent NFAT pathway and an activation pathway for c-Jun or MITF in rheumatoid arthritis
Q35740987The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts
Q51810609The Importance of 11α-OH, 15-oxo, and 16-en Moieties of 11α-Hydroxy-15-oxo-kaur-16-en-19-oic Acid in Its Inhibitory Activity on Melanogenesis.
Q30009200The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival
Q28274046The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor
Q42182548The inhibition of RANKL-induced osteoclastogenesis through the suppression of p38 signaling pathway by naringenin and attenuation of titanium-particle-induced osteolysis
Q52019222The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes.
Q37428651The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF).
Q38048776The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look
Q28251189The regulation of cathepsin K gene expression
Q37397466The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue
Q37931402The role of mitogen- and stress-activated protein kinase pathways in melanoma
Q38238861The roles of microphthalmia-associated transcription factor and pigmentation in melanoma
Q35834767The transcription network regulating melanocyte development and melanoma
Q83324534Transcriptional activation of tyrosinase gene by human placental sphingolipid
Q28679148Transcriptional regulation by the MAP kinase signaling cascades
Q100465050Transcriptional regulators and alterations that drive melanoma initiation and progression
Q28592680UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1)
Q28216853Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway
Q33344607Vitiligo puzzle: the pieces fall in place
Q33876438[6]-Shogaol inhibits α-MSH-induced melanogenesis through the acceleration of ERK and PI3K/Akt-mediated MITF degradation
Q21136315miR-148 regulates Mitf in melanoma cells
Q44536102p-Coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat model.