BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

article published in the Proceedings of the National Academy of Sciences of the United States of America

BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1073/PNAS.1810498115
P932PMC publication ID6140509
P698PubMed publication ID30150413

P50authorPanagis FilippakopoulosQ28320317
Helen J KnowlesQ39272124
Linxin LiQ62517934
Hannah BrunsdonQ87700859
E. Elizabeth PattonQ87700864
Kao Chin NgeowQ91165111
P2093author name stringRoman Fischer
Sarah Andrews
Stefan Knapp
Eiríkur Steingrímsson
Katherine L B Borden
Colin R Goding
Laurent Volpon
Georgina Berridge
Sarah Picaud
Zhiqiang Zeng
Hans J Friedrichsen
Richard Lisle
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The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleusQ27936804
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Sumoylation of MITF and its related family members TFE3 and TFEBQ28118825
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Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progressionQ28591011
Identification of a signal for rapid export of proteins from the nucleusQ29547742
A short amino acid sequence able to specify nuclear locationQ29547781
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanomaQ29614282
Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycleQ29619289
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Leucine-rich nuclear-export signals: born to be weakQ31151910
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A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitorsQ34132936
Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesisQ34253185
Sumoylation modulates transcriptional activity of MITF in a promoter-specific mannerQ34312986
Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasisQ34338564
GSK3 takes centre stage more than 20 years after its discoveryQ34374129
MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.Q35062693
Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursorsQ35071659
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.Q35186010
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanomaQ35596369
A novel recurrent mutation in MITF predisposes to familial and sporadic melanomaQ35699278
Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1.Q35968782
Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma developmentQ36103651
Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF.Q36512897
The recessive phenotype displayed by a dominant negative microphthalmia-associated transcription factor mutant is a result of impaired nucleation potentialQ36557590
Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomesQ36618911
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.Q36793719
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolismQ37378754
Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma.Q37384015
MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein functionQ37463551
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.Q37618946
A localized Wnt signal orients asymmetric stem cell division in vitroQ37664730
Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regenerationQ38394850
Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway.Q38526803
Genetics of melanoma progression: the rise and fall of cell senescenceQ38589518
A melanoma subtype with intrinsic resistance to BRAF inhibition identified by receptor tyrosine kinases gene-driven classification.Q38903238
A melanocyte lineage program confers resistance to MAP kinase pathway inhibitionQ39067618
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.Q39193337
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinomaQ39455824
Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny.Q39600607
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damageQ39622746
Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas.Q39715217
Braf(V600E) cooperates with Pten loss to induce metastatic melanomaQ39873596
Mitf-D, a newly identified isoform, expressed in the retinal pigment epithelium and monocyte-lineage cells affected by Mitf mutations.Q40738107
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signalingQ40756889
Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significanceQ40913428
Temperature-sensitive splicing of mitfa by an intron mutation in zebrafishQ41732789
A conditional zebrafish MITF mutation reveals MITF levels are critical for melanoma promotion vs. regression in vivoQ41884220
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signatureQ42804978
Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper proteinQ44500763
Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmiaQ47860146
Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a.Q52169523
MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytesQ59096765
P4510describes a project that usesImageJQ1659584
P433issue37
P407language of work or nameEnglishQ1860
P304page(s)E8668-E8677
P577publication date2018-08-27
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleBRAF/MAPK and GSK3 signaling converges to control MITF nuclear export
P478volume115

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cites work (P2860)
Q917449343,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes
Q99565169Integrative Genomic Analysis Reveals Cancer-Associated Gene Mutations in Chronic Myeloid Leukemia Patients with Resistance or Intolerance to Tyrosine Kinase Inhibitor
Q92254234MITF-the first 25 years
Q90424217Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities

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