Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis

scientific article published on 03 March 2009

Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M809789200
P932PMC publication ID2673317
P698PubMed publication ID19258321

P2093author name stringPing Zhang
Jianzhong Liu
Xu Feng
Suzanne M Michalek
Nasser Said-Al-Naief
Shunqing Wang
P2860cites workStimulation by toll-like receptors inhibits osteoclast differentiationQ24301850
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patientsQ24550658
RANK is essential for osteoclast and lymph node developmentQ24598872
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Pathogen recognition and innate immunityQ27861084
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand familiesQ28137631
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-SrcQ28142620
Bone resorption by osteoclastsQ28145169
The TNF and TNF receptor superfamilies: integrating mammalian biologyQ28203717
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systemsQ28294477
A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast functionQ28364534
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Osteoclast differentiation and activationQ29547556
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubismQ30157499
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptorsQ32024958
Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)Q73907464
Activation of NF-kappaB is involved in the survival of osteoclasts promoted by interleukin-1Q74424521
TLR4-mediated survival of macrophages is MyD88 dependent and requires TNF-alpha autocrine signallingQ79880502
Functional identification of three receptor activator of NF-kappa B cytoplasmic motifs mediating osteoclast differentiation and functionQ80865746
Receptor activator of NF-kappaB (RANK) cytoplasmic motif, 369PFQEP373, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4Q81424180
A novel receptor activator of NF-kappaB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineageQ82062490
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclastsQ33939357
Dental biofilms: difficult therapeutic targetsQ34128638
All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transductionQ34543653
Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infectionQ35008871
Humoral immune responses in gingival crevice fluid: local and systemic implicationsQ35092097
Hard labour: bacterial infection of the skeleton.Q35601796
Modulation of osteoclast differentiationQ35957509
The bacterial etiology of destructive periodontal disease: current conceptsQ36056602
Regulatory roles and molecular signaling of TNF family members in osteoclastsQ36074904
Roles of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in periodontal health and diseaseQ36703949
Novel host response therapeutic approaches to treat periodontal diseases.Q36703987
Signaling to NF-kappaB by Toll-like receptorsQ37009320
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.Q37372701
TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligandQ37413745
Microbial complexes in subgingival plaqueQ38553206
Effects of prostaglandin E2 and lipopolysaccharide on osteoclastogenesis in RAW 264.7 cellsQ39567498
Bacteria induce osteoclastogenesis via an osteoblast-independent pathway.Q39655080
Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cellsQ39792472
Bacterially induced bone destruction: mechanisms and misconceptions.Q39825282
Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cellsQ40114184
A synthetic analog of alpha-galactosylceramide induces macrophage activation via the TLR4-signaling pathwaysQ40143681
Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages.Q40745157
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signalingQ40756889
Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.Q40870297
Osteoclasts, macrophages, and the molecular mechanisms of bone resorptionQ41431482
Periodontal diseases: microbial factorsQ41444992
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.Q41649459
Mechanisms of alveolar bone destruction in periodontitis.Q41754991
Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK.Q43775920
Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL.Q43864464
Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophagesQ44343190
Lipopolysaccharide-induced osteoclastogenesis in Src homology 2-domain phosphatase-1-deficient viable motheaten miceQ44779377
Appearance of osteoclasts by injections of lipopolysaccharides in rat periodontal tissueQ44976066
Local bone injections of LPS and M-CSF increase bone resorption by different pathways in vivo in rats.Q51670417
Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function.Q53768934
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-βQ57675150
Interleukin-4 Reversibly Inhibits Osteoclastogenesis via Inhibition of NF-κB and Mitogen-activated Protein Kinase SignalingQ58085461
Dual Modulation of Osteoclast Differentiation by LipopolysaccharideQ58456589
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor geneQ59092154
Quantitative analyses of osteoclast changes in resorbing bone organ culturesQ67674065
The effect of lipopolysaccharide from the oral bacterium Bacteroides gingivalis on osteoclastic resorption of sperm-whale dentine slices in vitroQ68841823
Bone resorption stimulated by lipopolysaccharides from Bacteroides, Fusobacterium and Veillonella, and by the lipid A and the polysaccharide part of Fusobacterium lipopolysaccharideQ70156593
Comparison of the mechanisms of bone resorption induced by 1 alpha,25-dihydroxyvitamin D3 and lipopolysaccharidesQ70298423
Facial skeletal growth in growing "toothless" osteopetrotic (op/op) mice: radiographic findingsQ73579680
P4510describes a project that usesImageJQ1659584
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectlipopolysaccharideQ421804
P304page(s)12512-12523
P577publication date2009-03-03
P1433published inJournal of Biological ChemistryQ867727
P1476titleMolecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis
P478volume284

Reverse relations

cites work (P2860)
Q54286064Activation of the liver X receptor-β potently inhibits osteoclastogenesis from lipopolysaccharide-exposed bone marrow-derived macrophages.
Q36315765Augmented LPS responsiveness in type 1 diabetes-derived osteoclasts
Q84380039Chemotactic and immunoregulatory properties of bone cells are modulated by endotoxin-stimulated lymphocytes
Q98465737Chronic Exposure of Gingival Fibroblasts to TLR2 or TLR4 Agonist Inhibits Osteoclastogenesis but Does Not Affect Osteogenesis
Q42270419Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein
Q47104810Cyclophosphamide causes osteoporosis in C57BL/6 male mice: suppressive effects of cyclophosphamide on osteoblastogenesis and osteoclastogenesis
Q50137945Dietary Fats and Osteoarthritis: Insights, Evidences, and New Horizons
Q40332591Effect of Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) on the expression of EphA2 in osteoblasts and osteoclasts
Q39344809Effects of Porphyromonas gingivalis surface-associated material on osteoclast formation
Q39490131Exogenous regucalcin stimulates osteoclastogenesis and suppresses osteoblastogenesis through NF-κB activation
Q26863571Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8
Q92405045Finding a Toll on the Route: The Fate of Osteoclast Progenitors After Toll-Like Receptor Activation
Q37238209Hyperglycemia induced and intrinsic alterations in type 2 diabetes-derived osteoclast function
Q36444288IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1).
Q34313876Infection of RANKL-primed RAW-D macrophages with Porphyromonas gingivalis promotes osteoclastogenesis in a TNF-α-independent manner
Q37438518Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors
Q39018581Involvement of redox balance in in vitro osteoclast formation of RAW 264.7 macrophage cells in response to LPS.
Q36188882Melatonin Receptor Agonists as the "Perioceutics" Agents for Periodontal Disease through Modulation of Porphyromonas gingivalis Virulence and Inflammatory Response
Q64060861MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation
Q27315989Modulation of osteoclastogenesis with macrophage M1- and M2-inducing stimuli
Q35664993Molecular mechanisms of the biphasic effects of interferon-γ on osteoclastogenesis
Q41583248NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis
Q36257329Nucleosides accelerate inflammatory osteolysis, acting as distinct innate immune activators
Q39475508Oral administration of prostaglandin E(2)-specific receptor 4 antagonist inhibits lipopolysaccharide-induced osteoclastogenesis in rat periodontal tissue
Q89818128Osteoclastogenesis in Periodontal Diseases: Possible Mediators and Mechanisms
Q35890262Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion
Q38741964PKR regulates LPS-induced osteoclast formation and bone destruction in vitro and in vivo
Q42124151Plasmin is essential in preventing periodontitis in mice
Q37609527Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro
Q36751534Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss.
Q33916514Retracted: Molecular Mechanism of Thiazolidinedione-Mediated Inhibitory Effects on Osteoclastogenesis
Q35666187Rhinacanthin C Inhibits Osteoclast Differentiation and Bone Resorption: Roles of TRAF6/TAK1/MAPKs/NF-κB/NFATc1 Signaling
Q55171215Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function.
Q34774474Secretion of a truncated osteopetrosis-associated transmembrane protein 1 (OSTM1) mutant inhibits osteoclastogenesis through down-regulation of the B lymphocyte-induced maturation protein 1 (BLIMP1)-nuclear factor of activated T cells c1 (NFATc1) ax
Q36356941Serum amyloid A inhibits RANKL-induced osteoclast formation
Q35085107TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaB.
Q38289811TLR4 signalling in osteoarthritis--finding targets for candidate DMOADs.
Q37287589The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis
Q47953854The expression of ERK and JNK in patients with an endemic osteochondropathy, Kashin-Beck disease
Q45422823The intact strontium ranelate complex stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation
Q38763612The osteoimmunology of alveolar bone loss
Q35987370The role of SH3BP2 in the pathophysiology of cherubism
Q28385635Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss
Q54977323Toll-like receptor 2 activation primes and upregulates osteoclastogenesis via lox-1.
Q35386678Toll-like receptor 4 mediates the regenerative effects of bone grafts for calvarial bone repair
Q39550193Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation
Q37360437γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis

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