Aspartate β-Hydroxylase expression promotes a malignant pancreatic cellular phenotype

scientific article

Aspartate β-Hydroxylase expression promotes a malignant pancreatic cellular phenotype is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.2840
P8608Fatcat IDrelease_qs5u3763erge7nvatfludrimwy
P932PMC publication ID4359229
P698PubMed publication ID25483102
P5875ResearchGate publication ID269281295

P50authorMark J. OlsenQ73035272
P2093author name stringYu Li
Xiaoqun Dong
Qi Tang
Jack R Wands
Xuesong Chen
Qiushi Lin
Arihiro Aihara
Chiung-Kuei Huang
Christina Nadolny
Gregory Gabriel
Rolf Carlson
Waihong Chung
P2860cites workOverexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinomaQ24562001
Cancer statistics, 2013Q27860762
Overexpression of human aspartyl (asparaginyl) beta-hydroxylase is associated with malignant transformationQ28139424
Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctinQ28144446
Antisense oligodeoxynucleotides directed against aspartyl (asparaginyl) β-hydroxylase suppress migration of cholangiocarcinoma cellsQ28201030
Role of aspartyl-(asparaginyl) beta-hydroxylase in placental implantation: Relevance to early pregnancy lossQ28261542
Notch signalling: a simple pathway becomes complexQ29555851
Concise review: clinical programs of stem cell therapies for liver and pancreasQ30555472
WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinomaQ30571825
Upregulation of Wnt5a promotes epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cellsQ33828419
Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migrationQ33944605
Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancerQ34023117
cDNA cloning and expression of bovine aspartyl (asparaginyl) beta-hydroxylaseQ34249628
EGF-like domains in extracellular matrix proteins: localized signals for growth and differentiation?Q34504931
IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancerQ34958659
Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epitheliumQ35103047
IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migrationQ35144510
K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomasQ35992132
Signaling networks in human pluripotent stem cellsQ36604800
Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer.Q36881446
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasiaQ36980230
Insulin receptor-overexpressing β-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activationQ36997038
Upregulation of T-cell factor-4 isoform-responsive target genes in hepatocellular carcinomaQ36997259
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinomaQ37068621
LRH1 as a driving factor in pancreatic cancer growthQ37623867
Insulin-like growth factor signaling as a therapeutic target in pancreatic cancerQ37865028
Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancersQ37966605
Notch signaling in pancreatic cancer: oncogene or tumor suppressor?Q38094850
MicroRNA-29a induces resistance to gemcitabine through the Wnt/β-catenin signaling pathway in pancreatic cancer cellsQ39117777
Canonical wnt signaling is required for pancreatic carcinogenesisQ39140268
Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancerQ39877573
Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase CdeltaQ39887874
Invertebrate aspartyl/asparaginyl beta-hydroxylase: potential modification of endogenous epidermal growth factor-like modules.Q41593648
Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathwayQ42833516
Overexpression of aspartyl-(asparaginyl)-beta-hydroxylase in hepatocellular carcinoma is associated with worse surgical outcomeQ43005656
P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 miceQ48279087
A critical role for notch signaling in the formation of cholangiocellular carcinomas.Q50945875
LRH1 promotes pancreatic cancer metastasis.Q53055319
Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells.Q53631737
Pancreatic CancerQ54135367
Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms.Q54590341
Site-directed mutagenesis of residues in a conserved region of bovine aspartyl (asparaginyl) beta-hydroxylase: evidence that histidine 675 has a role in binding Fe2+Q71165576
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesisQ73614651
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cellsQ74624551
Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cellsQ82698906
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
P304page(s)1231-1248
P577publication date2015-01-01
P1433published inOncotargetQ1573155
P1476titleAspartate β-Hydroxylase expression promotes a malignant pancreatic cellular phenotype
P478volume6

Reverse relations

cites work (P2860)
Q1007621372-Oxoglutarate-dependent dioxygenases in cancer
Q35949450Anti-Tumor Effects of Second Generation β-Hydroxylase Inhibitors on Cholangiocarcinoma Development and Progression.
Q91622958Anti-tumor activity of antibody drug conjugate targeting aspartate-β-hydroxylase in pancreatic ductal adenocarcinoma
Q57112122Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation
Q98564461Aspartate β-hydroxylase as a target for cancer therapy
Q36723189Aspartate β-hydroxylase modulates cellular senescence through glycogen synthase kinase 3β in hepatocellular carcinoma
Q92332826Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway
Q37485171Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas
Q90974954Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
Q95840325Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
Q54967454Clinically relevant inflammatory breast cancer patient-derived xenograft-derived ex vivo model for evaluation of tumor-specific therapies.
Q59354375Construction and Characterization of Adenovirus Vectors Encoding Aspartate--Hydroxylase to Preliminary Application in Immunotherapy of Hepatocellular Carcinoma
Q47331366Ethanol-Induced White Matter Atrophy Is Associated with Impaired Expression of Aspartyl-Asparaginyl-β-Hydroxylase (ASPH) and Notch Signaling in an Experimental Rat Model
Q42366399Lambda phage-based vaccine induces antitumor immunity in hepatocellular carcinoma
Q54111731MiR-200a inhibits cell proliferation and EMT by down-regulating the ASPH expression levels and affecting ERK and PI3K/Akt pathways in human hepatoma cells.
Q26784068Notch signaling: an emerging therapeutic target for cancer treatment
Q90127696Prometastatic Secretome Trafficking via Exosomes Initiates Pancreatic Cancer Pulmonary Metastasis
Q59329484Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update
Q37679979Role of Notch signaling pathway in pancreatic cancer
Q93207896Synthesis of Novel Pyridine-carboxylates as Small-Molecule Inhibitors of Human Aspartate/Asparagine-β-Hydroxylase

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