Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation

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Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation is …
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scholarly articleQ13442814

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P356DOI10.4161/21688370.2014.977176
P932PMC publication ID4372021
P698PubMed publication ID25838982

P2093author name stringJ D Schulzke
R Rosenthal
C Barmeyer
J Luettig
P2860cites workEpithelial Tight Junction Structure in the Jejunum of Children with Acute and Treated Celiac SprueQ56972227
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structureQ57179984
Comparative tight junction protein expressions in colonic Crohn’s disease, ulcerative colitis, and tuberculosis: a new perspectiveQ57840006
HIV-1 p24 but not proviral load is increased in the intestinal mucosa compared with the peripheral blood in HIV-infected patientsQ58136222
Kinetics of Adhesion Mediated by Extracellular Loops of Claudin-2 as Revealed by Single-Molecule Force SpectroscopyQ58186370
Paracellular versus Transcellular Intestinal Permeability to Gliadin Peptides in Active Celiac DiseaseQ59387471
Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's diseaseQ62572598
Distinct cytokine patterns in early and chronic ileal lesions of Crohn's diseaseQ62660272
Tight junctions of jejunal surface and crypt cells in celiac disease: a freeze-fracture studyQ69697432
Intestinal permeability and the prediction of relapse in Crohn's diseaseQ72220492
Absence of functional peroxisome proliferator-activated receptor-alpha enhanced ileum permeability during experimental colitisQ80362362
The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stabilityQ80561465
Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblastsQ81163296
Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel diseaseQ82215769
IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migrationQ82829186
Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac diseaseQ82836848
Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac diseaseQ83180909
Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small IntestineQ84779796
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Microbial translocation is a cause of systemic immune activation in chronic HIV infectionQ22251054
Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathyQ24670256
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsQ24682136
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinQ24682664
Manner of interaction of heterogeneous claudin species within and between tight junction strandsQ24683327
Crystal structure of a claudin provides insight into the architecture of tight junctionsQ27690052
Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segmentsQ28209952
Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alphaQ28212968
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cellsQ28214827
Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activityQ28241499
Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigmsQ28249095
SUMOylation of claudin-2Q28269524
Claudin-2, a component of the tight junction, forms a paracellular water channelQ28282138
Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cellsQ28284028
Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharidesQ28295199
Permeability of human HT-29/B6 colonic epithelium as a function of apoptosisQ28348796
Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infectionQ29619124
The primary defect in experimental ileitis originates from a nonhematopoietic sourceQ30439653
Alterations of the intestinal transport and processing of gliadin peptides in celiac diseaseQ30979336
Crohn's disease and the NOD2 gene: a role for paneth cellsQ33187690
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's diseaseQ33249005
CARD15/NOD2 is required for Peyer's patches homeostasis in miceQ33287474
Mechanisms of epithelial translocation of the alpha(2)-gliadin-33mer in coeliac sprueQ33321475
TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signalingQ33408865
Inflamed pouch mucosa possesses altered tight junctions indicating recurrence of inflammatory bowel diseaseQ33458456
Arcobacter butzleri induces barrier dysfunction in intestinal HT-29/B6 cellsQ33482408
Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: a novel model for studying the pathomechanisms of inflammatory bowel disease cytokinesQ33491056
Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocationQ33553358
Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivityQ33782512
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.Q40345753
Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like processQ40415725
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeationQ40666802
Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial riskQ40735088
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expressionQ41917631
The jejunal secretion of histamine is increased in active Crohn's diseaseQ41933777
Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac diseaseQ41965718
Claudins regulate the intestinal barrier in response to immune mediatorsQ42488651
Claudin-2 is selectively expressed in proximal nephron in mouse kidneyQ43761068
Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac diseaseQ43864177
Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infectionQ44947174
Cysteine mutagenesis to study the structure of claudin-2 paracellular pores.Q45963238
Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patientsQ46308412
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.Q46592696
Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-α on tight junction proteins and signaling pathways in intestinal epithelial cellsQ46877467
Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis.Q51005301
Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect.Q51047222
Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene.Q52118761
TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.Q52550005
Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients.Q52598230
A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis.Q52628213
Microbial butyrate and its role for barrier function in the gastrointestinal tract.Q52887776
Defective tight junctions in refractory celiac disease.Q52887777
Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging.Q52960542
Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis.Q52969889
Expression profiling of claudins in the human gastrointestinal tract in health and during inflammatory bowel disease.Q54281028
Changes in the expression of claudins in active ulcerative colitis.Q54498951
Tight junction proteins contribute to barrier properties in human pleuraQ56972141
Mechanisms of diarrhea in collagenous colitisQ56972206
Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitisQ56972218
Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivoQ33788423
Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membraneQ34049874
The HIV-1 transactivator factor (Tat) induces enterocyte apoptosis through a redox-mediated mechanismQ34117587
Molecular structure of tight junctions and their role in epithelial transport.Q34302113
Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitutionQ34440722
Distinct profiles of effector cytokines mark the different phases of Crohn's diseaseQ34563301
STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunctionQ35061825
Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 geneQ35129026
Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?Q35760212
Setting up a selective barrier at the apical junction complexQ35804794
Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cellsQ36316586
Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regenerationQ36423910
Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomesQ36452928
STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokinesQ36586297
Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel diseaseQ36732009
Biology of claudins.Q36956748
Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction siteQ37023274
Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteinesQ37051296
Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10bQ37311990
Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activityQ37398298
Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.Q37451902
Cellular and molecular mechanism of interleukin-1β modulation of Caco-2 intestinal epithelial tight junction barrierQ37580772
Comprehensive cysteine-scanning mutagenesis reveals Claudin-2 pore-lining residues with different intrapore locationsQ37622542
Epithelial barriers in intestinal inflammationQ37835835
HIV infection and the intestinal mucosal barrierQ38021495
Claudins and other tight junction proteinsQ38110750
Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epitheliumQ38417912
The impact of attending a behavioural intervention on HIV incidence in Masaka, UgandaQ38881462
TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signalingQ39634008
Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayersQ39642580
Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function.Q39903368
Comparative characterization of mouse rectum CMT93-I and -II cells by expression of claudin isoforms and tight junction morphology and functionQ40045938
Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistanceQ40080707
Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4.Q40104924
Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2.Q40129999
PDZ domain binding selectivity is optimized across the mouse proteomeQ40191457
Microarray analysis of butyrate regulated genes in colonic epithelial cellsQ40331870
P433issue1-2
P921main subjectinflammationQ101991
P304page(s)e977176
P577publication date2015-04-03
P1433published inTissue BarriersQ15708770
P1476titleClaudin-2 as a mediator of leaky gut barrier during intestinal inflammation
P478volume3

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