| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Igor A Kaltashov | |
| Rinat R Abzalimov | |||
| Cedric E Bobst | |||
| Guanbo Wang | |||
| Shunhai Wang | |||
| Burcu Baykal | |||
| P2860 | cites work | Electrospray ionization mass spectrometry of highly heterogeneous protein systems: protein ion charge state assignment via incomplete charge reduction | Q84788287 |
| A role for the MS analysis of nucleic acids in the post-genomics age | Q84865221 | ||
| Structure of the human transferrin receptor-transferrin complex | Q27643181 | ||
| Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry | Q27654019 | ||
| Primary structure effects on peptide group hydrogen exchange | Q29614750 | ||
| Structural features of interferon-gamma aggregation revealed by hydrogen exchange | Q30309368 | ||
| Early development of therapeutic biologics--pharmacokinetics. | Q30352837 | ||
| Analysis of posttranslational modifications of proteins by tandem mass spectrometry. | Q30354938 | ||
| Beyond gene sequencing: analysis of protein structure with mass spectrometry. | Q30371170 | ||
| Mass spectrometry combined with oxidative labeling for exploring protein structure and folding. | Q30379641 | ||
| Post-translational modifications differentially affect IgG1 conformation and receptor binding. | Q30384877 | ||
| The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies | Q30401825 | ||
| De novo sequencing of peptides by MS/MS. | Q30938649 | ||
| Peptide and protein de novo sequencing by mass spectrometry | Q31014914 | ||
| Glycosaminoglycans as naturally occurring combinatorial libraries: developing a mass spectrometry-based strategy for characterization of anti-thrombin interaction with low molecular weight heparin and heparin oligomers | Q33292010 | ||
| Mass spectrometry for structural characterization of therapeutic antibodies | Q33362439 | ||
| Toward top-down determination of PEGylation site using MALDI in-source decay MS analysis | Q33385574 | ||
| Mass spectrometric analysis of innovator, counterfeit, and follow-on recombinant human growth hormone | Q33410181 | ||
| Determination of the mechanism of action of anti-FasL antibody by epitope mapping and homology modeling | Q33480207 | ||
| H/D exchange and mass spectrometry in the studies of protein conformation and dynamics: is there a need for a top-down approach? | Q33585139 | ||
| MALDI linear TOF mass spectrometry of PEGylated (glyco)proteins | Q33596015 | ||
| Characterization of the glycosylation occupancy and the active site in the follow-on protein therapeutic: TNK-tissue plasminogen activator | Q33605997 | ||
| Assessment of the quality and structural integrity of a complex glycoprotein mixture following extraction from the formulated biopharmaceutical drug product | Q33676479 | ||
| Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry | Q33684631 | ||
| Noncanonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry | Q33929235 | ||
| Acid-catalyzed oxygen-18 labeling of peptides | Q33943921 | ||
| Protein-peptide affinity determination using an h/d exchange dilution strategy: application to antigen-antibody interactions | Q34101341 | ||
| Existence of a noncanonical state of iron-bound transferrin at endosomal pH revealed by hydrogen exchange and mass spectrometry | Q34102858 | ||
| Mass spectrometric analysis of intact human monoclonal antibody aggregates fractionated by size-exclusion chromatography. | Q34127391 | ||
| Mass spectrometry of oligosaccharides. | Q34299101 | ||
| Structural and functional characterization of the trifunctional antibody catumaxomab | Q34619043 | ||
| Studies of biomolecular conformations and conformational dynamics by mass spectrometry | Q34811742 | ||
| Phenotype, diagnosis, and treatment of Gaucher's disease | Q34907714 | ||
| Effective drug delivery by PEGylated drug conjugates | Q35058925 | ||
| Mass spectrometry and glycomics | Q35097817 | ||
| Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies | Q35232337 | ||
| Hydrogen exchange methods to study protein folding | Q35850714 | ||
| Protein aggregation and its inhibition in biopharmaceutics | Q36010412 | ||
| Hydrogen exchange and mass spectrometry: A historical perspective | Q36550545 | ||
| A review of quantitative methods for proteomic studies | Q36680048 | ||
| Applications of mass spectrometry for the structural characterization of recombinant protein pharmaceuticals | Q36780879 | ||
| Mapping of protein disulfide bonds using negative ion fragmentation with a broadband precursor selection | Q36826093 | ||
| Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics. | Q37004962 | ||
| Detection and characterization of altered conformations of protein pharmaceuticals using complementary mass spectrometry-based approaches. | Q37065997 | ||
| Obstacles and pitfalls in the PEGylation of therapeutic proteins. | Q37088095 | ||
| Principles, approaches, and challenges for predicting protein aggregation rates and shelf life | Q37236306 | ||
| The impact of PEGylation on biological therapies | Q37263179 | ||
| IgG glycosylation analysis | Q37391496 | ||
| Emerging methods for the production of homogeneous human glycoproteins | Q37417435 | ||
| 18O2-labeling in quantitative proteomic strategies: a status report | Q37429056 | ||
| Bioanalysis of recombinant proteins and antibodies by mass spectrometry | Q37452812 | ||
| Strategies for analysis of the glycosylation of proteins: current status and future perspectives | Q37511909 | ||
| Pharmacokinetics of biotech drugs: peptides, proteins and monoclonal antibodies | Q37585356 | ||
| Carbohydrate analysis throughout the development of a protein therapeutic | Q37627225 | ||
| Pharmacological significance of glycosylation in therapeutic proteins | Q37628240 | ||
| Protein aggregation--pathways and influencing factors | Q37699481 | ||
| A systematic approach to protein glycosylation analysis: a path through the maze | Q37790268 | ||
| Critical comparison of MS and immunoassays for the bioanalysis of therapeutic antibodies | Q37810155 | ||
| Discrimination among IgG1-kappa monoclonal antibodies produced by two cell lines using charge state distributions in nanoESI-TOF mass spectra | Q39878491 | ||
| Insertion of the designed helical linker led to increased expression of tf-based fusion proteins | Q39918619 | ||
| Do ionic charges in ESI MS provide useful information on macromolecular structure? | Q40074233 | ||
| Probing molecular interactions in intact antibody: antigen complexes, an electrospray time-of-flight mass spectrometry approach | Q40198247 | ||
| Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry | Q40454983 | ||
| Positional isomers of monopegylated interferon alpha-2a: isolation, characterization, and biological activity | Q41112762 | ||
| Impact of oxidation on protein therapeutics: conformational dynamics of intact and oxidized acid-β-glucocerebrosidase at near-physiological pH. | Q41454207 | ||
| Studying noncovalent protein complexes by electrospray ionization mass spectrometry | Q41671168 | ||
| Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry | Q42122777 | ||
| Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies. | Q43070206 | ||
| Resolving disulfide structural isoforms of IgG2 monoclonal antibodies by ion mobility mass spectrometry | Q43778556 | ||
| High resolution, high-throughput amide deuterium exchange-mass spectrometry (DXMS) determination of protein binding site structure and dynamics: utility in pharmaceutical design. | Q43884669 | ||
| Dissociations of disulfide-linked gaseous polypeptide/protein anions: ion chemistry with implications for protein identification and characterization | Q44367851 | ||
| Isolation, structural characterization, and antiviral activity of positional isomers of monopegylated interferon alpha-2a (PEGASYS). | Q44487898 | ||
| Evidence for trisulfide bonds in a recombinant variant of a human IgG2 monoclonal antibody. | Q45932901 | ||
| Mass spectrometry detection and characterization of noncovalent protein complexes | Q46110253 | ||
| Gas-phase proton-transfer chemistry coupled with TOF mass spectrometry and ion mobility-MS for the facile analysis of poly(ethylene glycols) and PEGylated polypeptide conjugates | Q46341961 | ||
| Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry | Q46536053 | ||
| Towards absolute quantification of therapeutic monoclonal antibody in serum by LC-MS/MS using isotope-labeled antibody standard and protein cleavage isotope dilution mass spectrometry | Q46605479 | ||
| Preparation and characterization of monopegylated human granulocyte-macrophage colony-stimulating factor | Q46750776 | ||
| Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-Orbitrap mass spectrometer | Q46905334 | ||
| Optimization of a reversed-phase high-performance liquid chromatography/mass spectrometry method for characterizing recombinant antibody heterogeneity and stability | Q46920795 | ||
| A sensitive and high-throughput LC-MS/MS method for the quantification of pegylated-interferon-alpha2a in human serum using monolithic C18 solid phase extraction for enrichment | Q47785048 | ||
| Expression, purification, and characterization of rat interferon-beta, and preparation of an N-terminally PEGylated form with improved pharmacokinetic parameters | Q47995804 | ||
| Direct monitoring of heat-stressed biopolymers with temperature-controlled electrospray ionization mass spectrometry. | Q50684953 | ||
| A universal strategy for development of a method for absolute quantification of therapeutic monoclonal antibodies in biological matrices using differential dimethyl labeling coupled with ultra performance liquid chromatography-tandem mass spectromet | Q51608443 | ||
| Rapid whole monoclonal antibody analysis by mass spectrometry: An ultra scale-down study of the effect of harvesting by centrifugation on the post-translational modification profile. | Q51773472 | ||
| Molecular mass analysis of antibodies by on-line SEC-MS. | Q51791478 | ||
| Identification of intermolecular disulfide linkages in underivatised peptides using negative ion electrospray mass spectrometry. A joint experimental and theoretical study. | Q53572951 | ||
| Characterisation of a novel growth hormone variant comprising a thioether link between Cys182 and Cys189. | Q54439520 | ||
| Bio-affinity characterization mass spectrometry | Q58069446 | ||
| Comment on Houde, D; Berkowitz, S. A; Engen, J. R, The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies. J. Pharm. Sci. 2011, 100, 2071-2086 | Q58557043 | ||
| Identification of sites of degradation in a therapeutic monoclonal antibody by peptide mapping | Q67977680 | ||
| Localization of O-glycosylation sites in peptides by electron capture dissociation in a Fourier transform mass spectrometer | Q73144880 | ||
| Direct identification of intramolecular disulfide links in peptides using negative ion electrospray mass spectra of underivatised peptides. A joint experimental and theoretical study | Q81300702 | ||
| Single particle reconstruction of the human apo-transferrin-transferrin receptor complex | Q81606083 | ||
| Quantification of sifuvirtide in monkey plasma by an on-line solid-phase extraction procedure combined with liquid chromatography/electrospray ionization tandem mass spectrometry | Q81657723 | ||
| Top-down N-terminal sequencing of Immunoglobulin subunits with electrospray ionization time of flight mass spectrometry | Q82205512 | ||
| Characterization of trisulfide modification in antibodies | Q82565568 | ||
| Elucidation of PEGylation site with a combined approach of in-source fragmentation and CID MS/MS | Q83067154 | ||
| Epitope mapping by amide hydrogen/deuterium exchange coupled with immobilization of antibody, on-line proteolysis, liquid chromatography and mass spectrometry | Q83240189 | ||
| P433 | issue | 1 | |
| P921 | main subject | biotechnology | Q7108 |
| P304 | page(s) | 210-222 | |
| P577 | publication date | 2011-05-17 | |
| P1433 | published in | Biotechnology Advances | Q4915328 |
| P1476 | title | Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics | |
| P478 | volume | 30 |
| Q49884159 | A new liquid chromatography-mass spectrometry-based method to quantitate exogenous recombinant transferrin in cerebrospinal fluid: a potential approach for pharmacokinetic studies of transferrin-based therapeutics in the central nervous systems. |
| Q49164087 | A new strategy of using O18-labeled iodoacetic acid for mass spectrometry-based protein quantitation. |
| Q36588710 | A novel approach for the simultaneous quantification of a therapeutic monoclonal antibody in serum produced from two distinct host cell lines |
| Q38775433 | A novel rapid analysis using mass spectrometry to evaluate downstream refolding of recombinant human insulin-like growth factor-1 (mecasermin). |
| Q35568366 | Advanced mass spectrometry workflows for analyzing disulfide bonds in biologics |
| Q92848095 | Advancing Liquid Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Toward Ultrahigh-Throughput Analysis |
| Q36984283 | An 18O-labeling assisted LC/MS method for assignment of aspartyl/isoaspartyl products from Asn deamidation and Asp isomerization in proteins |
| Q46149367 | An Efficient and Rapid Method to Monitor the Oxidative Degradation of Protein Pharmaceuticals: Probing Tyrosine Oxidation with Fluorogenic Derivatization |
| Q35528871 | An improved fast photochemical oxidation of proteins (FPOP) platform for protein therapeutics |
| Q34489424 | Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2011-2012. |
| Q37022207 | Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars |
| Q38152378 | Applications of capillary electrophoresis in characterizing recombinant protein therapeutics |
| Q51268017 | Characterization of a PEGylated protein therapeutic by ion exchange chromatography with on-line detection by native ESI MS and MS/MS. |
| Q30369478 | Characterizing monoclonal antibody structure by carbodiimide/GEE footprinting |
| Q40987519 | Characterizing monoclonal antibody structure by carboxyl group footprinting |
| Q92891921 | Chemical characterization methods for the analysis of structural extracellular polymeric substances (EPS) |
| Q61814351 | Comprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry |
| Q35888367 | Conformational analysis of therapeutic proteins by hydroxyl radical protein footprinting |
| Q38465322 | Conformational effects in protein electrospray-ionization mass spectrometry |
| Q35164795 | Conjugated critical reagent characterization for ligand-binding assays: using MALDI-TOF-MS as an orthogonal tool to assess assay performance |
| Q57175988 | Covalent labeling-mass spectrometry with non-specific reagents for studying protein structure and interactions |
| Q51138751 | Deciphering the Biophysical Effects of Oxidizing Sulfur-Containing Amino Acids in Interferon-beta-1a using MS and HDX-MS. |
| Q40724867 | Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics |
| Q34691652 | Emerging mass spectrometry-based approaches to probe protein-receptor interactions: focus on overcoming physiological barriers |
| Q33732576 | Enhancing the quality of H/D exchange measurements with mass spectrometry detection in disulfide-rich proteins using electron capture dissociation |
| Q49965683 | Epitope characterization of anti-JAM-A antibodies using orthogonal mass spectrometry and surface plasmon resonance approaches. |
| Q40505663 | Evaluation of Gallium as a Tracer of Exogenous Hemoglobin-Haptoglobin Complexes for Targeted Drug Delivery Applications. |
| Q33924879 | Future of sustained protein delivery. |
| Q38110611 | High-resolution MS for structural characterization of protein therapeutics: advances and future directions |
| Q88500690 | How can native mass spectrometry contribute to characterization of biomacromolecular higher-order structure and interactions? |
| Q38055634 | Hydrogen-exchange mass spectrometry for the study of intrinsic disorder in proteins |
| Q33844511 | Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications |
| Q28535450 | Identification and monitoring of host cell proteins by mass spectrometry combined with high performance immunochemistry testing |
| Q88493653 | LC/MS at the whole protein level: Studies of biomolecular structure and interactions using native LC/MS and cross-path reactive chromatography (XP-RC) MS |
| Q26860505 | Long-term delivery of protein therapeutics |
| Q48356441 | Mapping the Interactions of Selective Biochemical Probes of Antibody Conformation by Hydrogen-Deuterium Exchange Mass Spectrometry |
| Q37567087 | Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies |
| Q36824142 | Mass spectrometry-guided optimization and characterization of a biologically active transferrin-lysozyme model drug conjugate |
| Q47230430 | Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry. |
| Q31056191 | Origin and prediction of free-solution interaction studies performed label-free. |
| Q50978761 | Performing native mass spectrometry analysis on therapeutic antibodies. |
| Q34761914 | QUDeX-MS: hydrogen/deuterium exchange calculation for mass spectra with resolved isotopic fine structure. |
| Q57482296 | Quality assessment and interference detection in targeted mass spectrometry data using machine learning |
| Q42081044 | Simultaneous monitoring of oxidation, deamidation, isomerization, and glycosylation of monoclonal antibodies by liquid chromatography-mass spectrometry method with ultrafast tryptic digestion |
| Q36588729 | Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting |
| Q50100063 | The NISTmAb tryptic peptide spectral library for monoclonal antibody characterization. |
| Q50874659 | The heights of biopharmaceutical complexity and the current reach of analytical instrumentation. |
| Q35511065 | Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometry |
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