| scholarly article | Q13442814 |
| P50 | author | Nicholas M. Graziane | Q55715183 |
| Nicholas J Brandon | Q56457567 | ||
| Michy P. Kelly | Q79325633 | ||
| Miles D. Houslay | Q37378801 | ||
| P2093 | author name string | A Sawa | |
| Q Wang | |||
| B Bates | |||
| Y Xie | |||
| Z Yan | |||
| K Kariya | |||
| S J Moss | |||
| H Murdoch | |||
| J B Lee | |||
| S Seshadri | |||
| N Taylor | |||
| K Ishizuka | |||
| R J Weinberg | |||
| M Pausch | |||
| V L Pulito | |||
| A J Dunlop | |||
| R A Crozier | |||
| A Hayashi-Takagi | |||
| E I Charych | |||
| R Revilla-Sanchez | |||
| P2860 | cites work | TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton | Q22010654 |
| The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton | Q24302294 | ||
| DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1 | Q24306600 | ||
| Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia | Q24306904 | ||
| Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling | Q24322974 | ||
| The kinase TNIK is an essential activator of Wnt target genes | Q24323107 | ||
| MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1 | Q24324640 | ||
| Common variants on chromosome 6p22.1 are associated with schizophrenia | Q24641881 | ||
| Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms | Q28141727 | ||
| Disruption of two novel genes by a translocation co-segregating with schizophrenia | Q28144559 | ||
| Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line | Q28239419 | ||
| Structural dynamics of dendritic spines in memory and cognition | Q37688520 | ||
| Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway. | Q38302646 | ||
| Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels. | Q40087646 | ||
| Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia. | Q40810638 | ||
| Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. | Q43271908 | ||
| Proteomic analysis of in vivo phosphorylated synaptic proteins. | Q45168689 | ||
| Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA). | Q46323394 | ||
| Stargazin modulates AMPA receptor gating and trafficking by distinct domains | Q46461380 | ||
| Behavioral phenotypes of Disc1 missense mutations in mice | Q48178658 | ||
| Rat hippocampal neurons in dispersed cell culture | Q48292684 | ||
| DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex | Q48516263 | ||
| Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder | Q60440984 | ||
| Gene expression of PSD95 in prefrontal cortex and hippocampus in schizophrenia | Q60513663 | ||
| Glutamate receptor expression in schizophrenic brain | Q73553182 | ||
| Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders | Q28245122 | ||
| Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry | Q28250422 | ||
| The DISC locus in psychiatric illness | Q28251868 | ||
| Association within a family of a balanced autosomal translocation with major mental illness | Q28257476 | ||
| Understanding the role of DISC1 in psychiatric disease and during normal development | Q28261398 | ||
| DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling | Q28282412 | ||
| DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 | Q28513802 | ||
| Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression | Q28566984 | ||
| DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2 | Q28574208 | ||
| DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1 | Q28576213 | ||
| The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking | Q28581802 | ||
| A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development | Q28582746 | ||
| Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1 | Q28583457 | ||
| DISC1, PDE4B, and NDE1 at the centrosome and synapse | Q28585118 | ||
| A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype | Q29417078 | ||
| Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting | Q29615874 | ||
| Glutamate and schizophrenia: beyond the dopamine hypothesis | Q33996803 | ||
| Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia | Q34098621 | ||
| Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses | Q34303320 | ||
| Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse | Q34321656 | ||
| Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site. | Q34407305 | ||
| Glutamate receptor genes: susceptibility factors in schizophrenia and depressive disorders? | Q34590422 | ||
| The neurobiology of autism | Q34699035 | ||
| Dendritic spine dynamics--a key role for kalirin-7. | Q34791771 | ||
| Dissecting DISC1 function through protein-protein interactions. | Q36979794 | ||
| How has DISC1 enabled drug discovery? | Q37022581 | ||
| Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders | Q37143117 | ||
| Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy | Q37143121 | ||
| Role of glutamate in schizophrenia: integrating excitatory avenues of research. | Q37256709 | ||
| Large-scale proteomics analysis of the human kinome | Q37258113 | ||
| Spine microdomains for postsynaptic signaling and plasticity | Q37425885 | ||
| Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. | Q37588242 | ||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1006-1023 | |
| P577 | publication date | 2010-09-14 | |
| P1433 | published in | Molecular Psychiatry | Q6895973 |
| P1476 | title | The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function | |
| P478 | volume | 16 |
| Q39469999 | A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons |
| Q53423408 | A Genome-Wide Search for Bipolar Disorder Risk Loci Modified by Mitochondrial Genome Variation. |
| Q39828938 | A null mutation in TNIK defines a novel locus for intellectual disability |
| Q47788104 | A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations |
| Q92441287 | A systematic review of genome-wide association studies of antipsychotic response |
| Q35008896 | A systems biology strategy to identify molecular mechanisms of action and protein indicators of traumatic brain injury |
| Q36083129 | A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins |
| Q35753205 | Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1 |
| Q39231042 | Application of induced pluripotent stem cells to understand neurobiological basis of bipolar disorder and schizophrenia |
| Q41475470 | Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population |
| Q47556858 | Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein. |
| Q36904298 | Constellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: potential substrate for working memory deficits in schizophrenia |
| Q36189837 | Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. |
| Q35091791 | DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes |
| Q37998459 | DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders |
| Q36282891 | DISC1 Protein Regulates γ-Aminobutyric Acid, Type A (GABAA) Receptor Trafficking and Inhibitory Synaptic Transmission in Cortical Neurons. |
| Q47380363 | DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis. |
| Q37698116 | DISC1 as a therapeutic target for mental illnesses. |
| Q28250914 | DISC1 at 10: connecting psychiatric genetics and neuroscience |
| Q41444596 | DISC1 causes associative memory and neurodevelopmental defects in fruit flies |
| Q36634401 | DISC1 genetics, biology and psychiatric illness |
| Q52671081 | DISC1 is a coordinator of intracellular trafficking to shape neuronal development and connectivity. |
| Q35112848 | DISC1 is associated with cortical thickness and neural efficiency |
| Q58761899 | DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness |
| Q48022410 | DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders |
| Q28302106 | DISC1-binding proteins in neural development, signalling and schizophrenia |
| Q43100153 | DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites |
| Q28393891 | DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness |
| Q43997962 | Different changes in cortical tumor necrosis factor-α-related pathways in schizophrenia and mood disorders |
| Q90814272 | Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK |
| Q37347839 | Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro |
| Q38203025 | Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. |
| Q42027335 | Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. |
| Q34222021 | Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses |
| Q35138731 | Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics. |
| Q38364235 | Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder. |
| Q30464730 | Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia |
| Q89367557 | Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders |
| Q39516790 | Enormous influence of TNIK knockdown on intracellular signals and cell survival |
| Q89747494 | Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders |
| Q30997126 | Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk |
| Q39179260 | Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade. |
| Q52675080 | Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study. |
| Q42611080 | Genetic interaction of DISC1 and Neurexin in the development of fruit fly glutamatergic synapses |
| Q38133757 | Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches. |
| Q39140608 | IP3 receptor mutations and brain diseases in human and rodents. |
| Q40234126 | Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK. |
| Q34804839 | Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. |
| Q30399814 | Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders |
| Q92477519 | Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance |
| Q35017276 | Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro |
| Q34233683 | Linking neurodevelopmental and synaptic theories of mental illness through DISC1 |
| Q34689361 | Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neurons |
| Q90216168 | Mechanisms underlying the role of DISC1 in synaptic plasticity |
| Q30826347 | Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits. |
| Q37161173 | Modulation of behavior by scaffolding proteins of the post-synaptic density |
| Q48077574 | NEURODEVELOPMENT. Adult cortical plasticity depends on an early postnatal critical period |
| Q38241786 | Novel treatment strategies for schizophrenia from improved understanding of genetic risk |
| Q41881027 | Organization of TNIK in dendritic spines |
| Q28567753 | PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence |
| Q89581110 | Parvalbumin Interneuron Dysfunction in a Thalamo-Prefrontal Cortical Circuit in Disc1 Locus Impairment Mice |
| Q44314262 | Phenotypic characterization of C57BL/6J mice carrying the Disc1 gene from the 129S6/SvEv strain. |
| Q40043676 | Preparation of synaptic plasma membrane and postsynaptic density proteins using a discontinuous sucrose gradient |
| Q30361244 | Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases. |
| Q60926354 | Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function |
| Q36486743 | Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits |
| Q82073984 | Psychiatric disorders: The risk of DISC — at the synapse |
| Q56530863 | Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in |
| Q42280876 | Regulation of N-methyl-D-aspartate receptors by disrupted-in-schizophrenia-1. |
| Q42380993 | Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus |
| Q39406264 | Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics. |
| Q61797149 | Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat |
| Q92833427 | Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders |
| Q26825577 | Synapse-specific contributions in the cortical pathology of schizophrenia |
| Q91959868 | Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model |
| Q37690413 | TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function |
| Q45731241 | The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein |
| Q47732733 | The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action |
| Q57027971 | The TRAX, DISC1, and GSK3 complex in mental disorders and therapeutic interventions |
| Q37633236 | The impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review. |
| Q34341876 | The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. |
| Q37621518 | The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice |
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