Essential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity

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Essential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.0685-11.2011
P932PMC publication ID3183742
P698PubMed publication ID21880903
P5875ResearchGate publication ID51608603

P2093author name stringCarly F Hale
Christopher W Cowan
Benjamin C Zirlin
Cody B Wood
Juan A Varela
Karen C Dietz
Leah S Leverich
Robert W Greene
P2860cites workVav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformationQ24515205
Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2Q24533404
Regulatory and signaling properties of the Vav familyQ24554307
Guidance molecules in synapse formation and plasticityQ24614257
Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptorsQ24649799
Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spinesQ24677936
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylationQ27627224
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene productQ28114879
Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapseQ28115583
The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spinesQ28115750
A role of actin filament in synaptic transmission and long-term potentiationQ28144564
Regulation of dendritic spine motility and stability by Rac1 and Rho kinase: evidence for two forms of spine motilityQ28270246
The Dbl family of oncogenesQ28288875
BDNF enhances quantal neurotransmitter release and increases the number of docked vesicles at the active zones of hippocampal excitatory synapsesQ28366751
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphologyQ28505203
Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesisQ28586276
Essential role for TrkB receptors in hippocampus-mediated learningQ28588099
Mechanism of TrkB-mediated hippocampal long-term potentiationQ28592383
The subspine organization of actin fibers regulates the structure and plasticity of dendritic spinesQ28596576
Lck regulates Vav activation of members of the Rho family of GTPasesQ28610619
Vav2 is an activator of Cdc42, Rac1, and RhoAQ28610652
Structural basis of long-term potentiation in single dendritic spinesQ29547598
Morphological changes in dendritic spines associated with long-term synaptic plasticityQ29614372
A simple method for organotypic cultures of nervous tissueQ29614375
Rational design and characterization of a Rac GTPase-specific small molecule inhibitorQ29616494
Evidence that protein constituents of postsynaptic membrane specializations are locally synthesized: analysis of proteins synthesized within synaptosomesQ30446925
Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors.Q30486698
Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampusQ33902823
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factorQ33932396
A caged Ab reveals an immediate/instructive effect of BDNF during hippocampal synaptic potentiationQ33952159
Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivoQ34196242
Vav proteins, adaptors and cell signaling.Q34405552
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines.Q34446029
VAV proteins as signal integrators for multi-subunit immune-recognition receptorsQ34718119
Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticityQ34762533
Cocaine regulates MEF2 to control synaptic and behavioral plasticityQ34818266
VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2Q36082465
Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signalingQ36096852
The actin cytoskeleton: integrating form and function at the synapseQ36200197
Spine expansion and stabilization associated with long-term potentiationQ36923761
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacyQ37143121
Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiationQ37267709
Local protein synthesis, actin dynamics, and LTP consolidationQ37286426
Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic functionQ40766021
Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons.Q41745546
Mutation at the TrkB PLC{gamma}-docking site affects hippocampal LTP and associative learning in conscious miceQ42138400
Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity.Q42825535
Miniature synaptic transmission and BDNF modulate dendritic spine growth and form in rat CA1 neuronesQ44590907
EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexinQ45345123
Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus.Q46186409
TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses.Q46437137
Vav family GEFs link activated Ephs to endocytosis and axon guidanceQ46453264
Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factorsQ46454414
Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors.Q46510765
Relative contribution of endogenous neurotrophins in hippocampal long-term potentiationQ48117154
Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout miceQ48188582
Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growthQ48320909
Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.Q52197312
Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice.Q52201421
Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampusQ59085769
Regulation of dendritic spine morphology by the rho family of small GTPases: antagonistic roles of Rac and RhoQ73010224
Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylationQ80804183
P4510describes a project that usesImageJQ1659584
P433issue35
P407language of work or nameEnglishQ1860
P921main subjectdendritic spineQ902079
P304page(s)12426-12436
P577publication date2011-08-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleEssential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity
P478volume31

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cites work (P2860)
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Q27026905Vav family exchange factors: an integrated regulatory and functional view

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