A systems approach to predict oncometabolites via context-specific genome-scale metabolic networks

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A systems approach to predict oncometabolites via context-specific genome-scale metabolic networks is …
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scholarly articleQ13442814

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P8978DBLP publication IDjournals/ploscb/NamCBHKZP14
P356DOI10.1371/JOURNAL.PCBI.1003837
P932PMC publication ID4168981
P698PubMed publication ID25232952
P5875ResearchGate publication ID265790985

P50authorBernhard PalssonQ4894212
Hojung NamQ56972646
Sangwoo KimQ41048366
P2093author name stringAarash Bordbar
Daniel C Zielinski
Daniel R Hyduke
Miguel Campodonico
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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenasesQ24632807
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Exploring the diversity of complex metabolic networks.Q33210262
Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale modelsQ33642720
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effectQ33851554
Enzyme promiscuity: a mechanistic and evolutionary perspectiveQ34021669
Energy balance for analysis of complex metabolic networksQ34178210
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydrataseQ34208791
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Highly parallel identification of essential genes in cancer cellsQ37068513
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MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.Q37410615
What makes an enzyme promiscuous?Q37676665
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Predicting drug targets and biomarkers of cancer via genome-scale metabolic modelingQ38052536
Basic and applied uses of genome‐scale metabolic network reconstructions of Escherichia coliQ38103147
Computational framework for predictive biodegradationQ39958425
A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011.Q40519259
The emerging role of fumarate as an oncometaboliteQ42255812
Metabolite and reaction inference based on enzyme specificitiesQ42616635
Metabolic engineering of Escherichia coli for direct production of 1,4-butanediolQ42733691
Discovery and analysis of novel metabolic pathways for the biosynthesis of industrial chemicals: 3-hydroxypropanoateQ43187436
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesaffyQ113334509
P433issue9
P921main subjectmetabolic networkQ2263094
P304page(s)e1003837
P577publication date2014-09-18
P1433published inPLOS Computational BiologyQ2635829
P1476titleA systems approach to predict oncometabolites via context-specific genome-scale metabolic networks
P478volume10

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