MELK-a conserved kinase: functions, signaling, cancer, and controversy

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MELK-a conserved kinase: functions, signaling, cancer, and controversy is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1046914693
P356DOI10.1186/S40169-014-0045-Y
P932PMC publication ID4385133
P698PubMed publication ID25852826
P5875ResearchGate publication ID274081374

P50authorHarley I KornblumQ114444398
P2093author name stringIchiro Nakano
Ahmed Mohyeldin
Monique Beullens
Jordyn Thiel
Ranjit Ganguly
P2860cites workThe maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancerQ39286062
Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expressionQ39497051
The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activationQ40333412
Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancersQ42808469
Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exitQ43085095
The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions.Q44846511
Methods for analysis of brain tumor stem cell and neural stem cell self-renewal.Q45937538
Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cellsQ46137091
Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas.Q46931943
Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cellsQ48664813
MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells.Q50994627
A functional analysis of MELK in cell division reveals a transition in the mode of cytokinesis during Xenopus development.Q53263078
Cancer stem cellsQ80312237
Cancer stem cells: an evolving conceptQ83213559
Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 familyQ21195232
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Q24310603
Substrate specificity and activity regulation of protein kinase MELKQ24338012
Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38)Q24533606
Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1Q28236635
Study on the inhibition of testicular polyadenylate polymerase stimulated by manganeseQ28341657
New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryoQ28506665
Expression of Melk, a new protein kinase, during early mouse developmentQ28511671
Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibitionQ28537936
Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cellsQ28585777
Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylationQ28590590
Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferationQ28591125
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsQ29616498
Dealing with energy demand: the AMP-activated protein kinaseQ33543966
Maternal embryonic leucine zipper kinase: key kinase for stem cell phenotype in glioma and other cancersQ33723151
MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.Q33762222
Melk-like kinase plays a role in hematopoiesis in the zebra fishQ33925180
Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathwayQ33960305
Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent mannerQ34044078
Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancerQ34530885
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular targetQ35127284
Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylationQ36033101
Programmed elimination of cells by caspase-independent cell extrusion in C. elegansQ36157242
Bcl-2 family member Bcl-G is not a proapoptotic protein.Q36347191
Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisionsQ36643905
MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.Q37098261
Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cellsQ37099799
Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancerQ37360234
Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivoQ37708563
Cortical localization of maternal embryonic leucine zipper kinase (MELK) implicated in cytokinesis in early xenopus embryosQ38577467
P304page(s)11
P577publication date2015-03-07
P1433published inClinical and translational medicineQ27724586
P1476titleMELK-a conserved kinase: functions, signaling, cancer, and controversy
P478volume4