Ordering gene function: the interpretation of epistasis in regulatory hierarchies

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Ordering gene function: the interpretation of epistasis in regulatory hierarchies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/0168-9525(92)90263-4
P932PMC publication ID3955268
P698PubMed publication ID1365397

P2093author name stringL Avery
S Wasserman
P2860cites workA gene product required for correct initiation of segmental determination in DrosophilaQ59070843
Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesisQ69368573
CDC36 and CDC39 are negative elements in the signal transduction pathway of yeastQ27936492
A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegansQ28274449
SUPERMAN, a regulator of floral homeotic genes in ArabidopsisQ33338889
Mutations causing constitutive invertase synthesis in yeast: genetic interactions with snf mutationsQ33952793
The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae.Q33957105
Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegansQ33958863
Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogasterQ33994066
Genetic control of programmed cell death in the nematode C. elegans.Q34196702
The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell deathQ34306496
Mating-defective ste mutations are suppressed by cell division cycle start mutations in Saccharomyces cerevisiaeQ36974815
Sex determination compared in Drosophila and CaenorhabditisQ37811672
Sex determination in mammalsQ39579416
Function of torso in determining the terminal anlagen of the Drosophila embryoQ44045802
Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinaseQ44558604
A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans.Q47069318
let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras proteinQ47069440
Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogasterQ47070232
Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeastQ57270194
P433issue9
P304page(s)312-316
P577publication date1992-09-01
P1433published inTrends in GeneticsQ2451468
P1476titleOrdering gene function: the interpretation of epistasis in regulatory hierarchies
P478volume8

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cites work (P2860)
Q34124493A decade of systems biology
Q28362273A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4
Q34559798A genetic interaction network model of a complex neurological disease
Q36375619A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae
Q37768765A systems-biology approach to modular genetic complexity
Q37614692Adding more content to screening: reactivation of FOXO as a therapeutic strategy
Q28213545An improved and highly standardised transformation procedure allows efficient production of single and multiple targeted gene-knockouts in a moss, Physcomitrella patens
Q33597707Automated identification of pathways from quantitative genetic interaction data
Q41670536Bayesian network model for identification of pathways by integrating protein interaction with genetic interaction data
Q40732271Chemosensory regulation of development in C. elegans
Q36470497Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor
Q33378070Combination chemical genetics
Q38711552Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.
Q34850230Comparison of profile similarity measures for genetic interaction networks
Q34570693Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network
Q40594442Current advances in abscisic acid action and signalling.
Q34288463Deconstruction of a neural circuit for hunger
Q21184166Derivation of genetic interaction networks from quantitative phenotype data
Q41887550Dissection of complex gene expression using the combined analysis of pleiotropy and epistasis
Q33978412Dissection of genetic pathways in C. elegans
Q35987554Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C. elegans
Q40699502Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling
Q48243283Dual gene activation and knockout screen reveals directional dependencies in genetic networks
Q28478651Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila
Q42174851Dynamic network-based epistasis analysis: boolean examples
Q33965510Effects of nullisomic chromosome deficiencies on conjugation events in Tetrahymena thermophila: insufficiency of the parental macronucleus to direct postzygotic development
Q24791723Enriching for direct regulatory targets in perturbed gene-expression profiles
Q34509968Epistasis analysis of four genes from Anabaena sp. strain PCC 7120 suggests a connection between PatA and PatS in heterocyst pattern formation
Q57681849Epistasis analysis with global transcriptional phenotypes
Q34587033Epistasis for fitness-related quantitative traits in Arabidopsis thaliana grown in the field and in the greenhouse
Q36414653Epistasis in tomato color mutations involves regulation of phytoene synthase 1 expression by cis-carotenoids
Q22122008Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems
Q33877466Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice.
Q54217450Evidence for non-additive influence of single nucleotide polymorphisms within the apolipoprotein E gene.
Q33969888FAR1, a negative regulatory locus required for the repression of the nitrate reductase gene in Chlamydomonas reinhardtii.
Q30671403Fisher's geometric model of adaptation meets the functional synthesis: data on pairwise epistasis for fitness yields insights into the shape and size of phenotype space
Q34572582Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster
Q36491912From classical genetics to quantitative genetics to systems biology: modeling epistasis
Q33766693Functional data analysis for identifying nonlinear models of gene regulatory networks
Q38550839Functional genomics in the mouse: phenotype-based mutagenesis screens
Q31153034Functional maps of protein complexes from quantitative genetic interaction data
Q43003386Gene network inference by probabilistic scoring of relationships from a factorized model of interactions.
Q47643703GenePath: a system for inference of genetic networks and proposal of genetic experiments.
Q24812746GenePath: from mutations to genetic networks and back
Q47246612Genetic Evidence for Roles of Yeast Mitotic Cyclins at Single-Stranded Gaps Created by DNA Replication
Q33967910Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation
Q28744676Genetic architecture of growth traits revealed by global epistatic interactions
Q27023184Genetic interaction networks: better understand to better predict
Q33965861Genetic interactions between the Drosophila Abelson (Abl) tyrosine kinase and failed axon connections (fax), a novel protein in axon bundles
Q54345856Genetic interactions improve models of quantitative traits.
Q43046092Genetic interactions: the missing links for a better understanding of cancer susceptibility, progression and treatment.
Q87682807Genome-Wide Fitness and Genetic Interactions Determined by Tn-seq, a High-Throughput Massively Parallel Sequencing Method for Microorganisms
Q54878172Genome-Wide Fitness and Genetic Interactions Determined by Tn-seq, a High-Throughput Massively Parallel Sequencing Method for Microorganisms.
Q33739364Genome‐Wide Fitness and Genetic Interactions Determined by Tn‐seq, a High‐Throughput Massively Parallel Sequencing Method for Microorganisms
Q33536854Gibberellin: inhibitor of an inhibitor of...?
Q28732199Growth of novel epistatic interactions by gene duplication
Q37574376Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase
Q53897342How missing genes interact.
Q35012837Hypothalamic survival circuits: blueprints for purposive behaviors
Q46841056Identifiability and inference of pathway motifs by epistasis analysis
Q36436018Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation
Q33690033Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis
Q47599775Identifying Gene Interaction Networks
Q38498519Identifying gene interaction networks
Q33300802Inferring cellular networks--a review
Q36851614Inferring gene function and network organization in Drosophila signaling by combined analysis of pleiotropy and epistasis
Q33609193Integrating physical and genetic maps: from genomes to interaction networks
Q33969169Interactions of liguleless1 and liguleless2 function during ligule induction in maize
Q35185565Interpreting interactions between treatments that slow aging
Q73477227Looms to weave genomic nets
Q46255275Manipulating the mouse genome: approaches and applications
Q28755007Maximal extraction of biological information from genetic interaction data
Q38743147Mechanisms of suppression: The wiring of genetic resilience.
Q36930517Models from experiments: combinatorial drug perturbations of cancer cells
Q64232908Modular epistasis and the compensatory evolution of gene deletion mutants
Q89983730Modularity/non-cumulativity of quantitative trait loci on blood pressure
Q33752657On the classification of epistatic interactions
Q36493700Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma
Q38112272Physiological and molecular mechanisms of salt and water homeostasis in the nematode Caenorhabditis elegans
Q42132833Predicting the effects of copy-number variation in double and triple mutant combinations
Q42860872Prediction of phenotype and gene expression for combinations of mutations
Q21146762Q&A: epistasis
Q35051808Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
Q28478118Quantitative epistasis analysis and pathway inference from genetic interaction data
Q34781501RNA-seq in the tetraploid Xenopus laevis enables genome-wide insight in a classic developmental biology model organism
Q28654521RNAi screening comes of age: improved techniques and complementary approaches
Q90244482Recent insights into the genotype-phenotype relationship from massively parallel genetic assays
Q38154247Regulation of PCP by the Fat signaling pathway
Q27935093Regulation of cell wall beta-glucan assembly: PTC1 negatively affects PBS2 action in a pathway that includes modulation of EXG1 transcription
Q33619990Role for protein-protein interaction databases in human genetics
Q91603873Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway
Q34119281Separate DNA Pol II- and Pol IV-dependent pathways of stress-induced mutation during double-strand-break repair in Escherichia coli are controlled by RpoS.
Q38783458Similarity analysis between chromosomes of Homo sapiens and monkeys with correlation coefficient, rank correlation coefficient and cosine similarity measures
Q40081460Sleeper cells: the stringent response and persistence in the Borreliella (Borrelia) burgdorferi enzootic cycle.
Q41884350Structure and function of a transcriptional network activated by the MAPK Hog1.
Q33677022Suppression mechanisms: themes from variations
Q33346295Suppressor of sessile spikelets1 functions in the ramosa pathway controlling meristem determinacy in maize
Q33622989Systematic interpretation of genetic interactions using protein networks
Q37277864Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions
Q24805253Systematic quantification of gene interactions by phenotypic array analysis
Q44380537The ABSCISIC ACID INSENSITIVE 3 (ABI3) gene is modulated by farnesylation and is involved in auxin signaling and lateral root development in Arabidopsis
Q34448367The Arabidopsis GAI gene defines a signaling pathway that negatively regulates gibberellin responses
Q55002438The Influence of Higher-Order Epistasis on Biological Fitness Landscape Topography.
Q33962292The Yak1 protein kinase of Saccharomyces cerevisiae moderates thermotolerance and inhibits growth by an Sch9 protein kinase-independent mechanism
Q42217583The combination of the functionalities of feedback circuits is determinant for the attractors' number and size in pathway-like Boolean networks
Q34604883The language of gene interaction
Q35204084The role of stomata in sensing and driving environmental change
Q36012774Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I.
Q34160384Two regulatory levels of transcriptional gene silencing in Arabidopsis.
Q81695269Universal epistasis analysis
Q38529033Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development.
Q34446684Use of pleiotropy to model genetic interactions in a population
Q35909625Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross
Q34229556What can causal networks tell us about metabolic pathways?
Q37402683What's Downstream? A Set of Classroom Exercises to Help Students Understand Recessive Epistasis
Q28818537Widespread Genetic Incompatibilities between First-Step Mutations during Parallel Adaptation of Saccharomyces cerevisiae to a Common Environment
Q36560619Yeast as a drug discovery platform in Huntington's and Parkinson's diseases
Q30540537barx1 represses joints and promotes cartilage in the craniofacial skeleton.
Q27312040edn1 and hand2 Interact in early regulation of pharyngeal arch outgrowth during zebrafish development

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