CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid arthritis: evidence from a case-control study

scientific article

CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid arthritis: evidence from a case-control study is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1050090179
P356DOI10.1186/S13075-015-0590-9
P932PMC publication ID4392874
P698PubMed publication ID25880754
P5875ResearchGate publication ID274838309

P2093author name stringJun Wang
Chun Li
Jing Zhang
Jianping Guo
Zhanguo Li
Yanyan Gao
Hua Ye
Minghua Deng
Yan Du
P2860cites workProtein complexes and functional modules in molecular networksQ24683305
Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimensQ24817108
WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput dataQ25255552
Gene expression analysis in RA: towards personalized medicineQ26825706
Defective Hepatic Response to Interferon and Activation of Suppressor of Cytokine Signaling 3 in Chronic Hepatitis CQ27478298
The KEGG resource for deciphering the genomeQ27860687
Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway.Q50509527
The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation.Q50949116
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.Q54528928
Rheumatoid synovial fluid T cells are sensitive to APO2L/TRAILQ80281913
Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cellsQ80622205
The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisQ27860872
Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activityQ28306204
Genetics and epigenetics of rheumatoid arthritisQ28534348
Direct regulation of Gata3 expression determines the T helper differentiation potential of NotchQ28594879
Relating whole-genome expression data with protein-protein interactionsQ30669147
Network-constrained regularization and variable selection for analysis of genomic dataQ31148172
Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of rheumatoid arthritis patientsQ33497339
MINT, the molecular interaction database: 2012 updateQ34233947
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritisQ34619592
Notch signaling regulates mouse and human Th17 differentiationQ35091395
Abnormal networks of immune response-related molecules in bone marrow cells from patients with rheumatoid arthritis as revealed by DNA microarray analysisQ35557902
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritisQ35752661
Apoptosis in rheumatoid arthritis: friend or foe.Q35839784
Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis.Q35869646
A systems biology approach for pathway level analysisQ36004656
A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.Q36094049
Krüppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cellsQ36452206
c-Cbl, a ubiquitin E3 ligase that targets active β-catenin: a novel layer of Wnt signaling regulationQ36635408
SOCS proteins, cytokine signalling and immune regulationQ36831668
Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.Q37146430
Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritisQ37206996
WNT signalling in the immune system: WNT is spreading its wingsQ37212748
Early and long-standing rheumatoid arthritis: distinct molecular signatures identified by gene-expression profiling in synoviaQ37270899
STAT3 in CD4+ T helper cell differentiation and inflammatory diseasesQ37323270
The different faces of Notch in T-helper-cell differentiationQ37376021
Low-density lipoprotein receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destructionQ37690622
The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cellsQ39889258
HIV-induced T-lymphocyte depletionQ40631503
The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis.Q42326337
Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritisQ45171003
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
P304page(s)76
P577publication date2015-03-22
P1433published inArthritis Research and TherapyQ15757229
P1476titleCD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid arthritis: evidence from a case-control study
P478volume17

Reverse relations

cites work (P2860)
Q89302987Analysis of Polymorphisms in the Mediator Complex Subunit 13-like (Med13L) Gene in the Context of Immune Function and Development of Experimental Arthritis
Q35768186Constitutive STAT3 Phosphorylation in Circulating CD4+ T Lymphocytes Associates with Disease Activity and Treatment Response in Recent-Onset Rheumatoid Arthritis
Q26750589Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases
Q64967594Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis
Q39298145Genomics, transcriptomics and proteomics to elucidate the pathogenesis of rheumatoid arthritis
Q58792295Identification of enhanced IFN-γ signaling in polyarticular juvenile idiopathic arthritis with mass cytometry
Q47299653Increased DOT1L in synovial biopsies of patients with OA and RA.
Q92243276MiR-195 restrains lung adenocarcinoma by regulating CD4+ T cell activation via the CCDC88C/Wnt signaling pathway: a study based on the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and bioinformatic analysis
Q47683816MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway.
Q92913113Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis
Q39344907Targeting the programmed cell death-1 pathway in rheumatoid arthritis.
Q58610422Transcriptome analysis of peripheral blood from patients with rheumatoid arthritis: a systematic review
Q35864859WNT5A transforms intestinal CD8αα⁺ IELs into an unconventional phenotype with pro-inflammatory features.

Search more.