The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

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The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2010-11-318873
P8608Fatcat IDrelease_hx54s44odjczrbp4qald2hkiuq
P932PMC publication ID3204734
P698PubMed publication ID21878675
P5875ResearchGate publication ID51606473

P50authorLynda ChinQ16207911
A. Thomas LookQ61435159
Stephen P HungerQ64215088
Takaomi SandaQ85892141
Shan ZhaQ89520181
P2093author name stringAlexei Protopopov
Frederick W Alt
Jianhua Zhang
Charles G Mullighan
Donna S Neuberg
Suzanne E Dahlberg
James R Downing
Alejandro Gutierrez
Lewis B Silverman
Stephen E Sallan
Stuart S Winter
Linda Holmfeldt
Alex Kentsis
Shann-Ching Chen
P2860cites workCOUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding proteinQ24534913
Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactionsQ27733960
The SWISS-MODEL workspace: a web-based environment for protein structure homology modellingQ27860637
Bcl11b is required for differentiation and survival of αβ T lymphocytesQ28592191
DNA recognition by Cys2His2 zinc finger proteinsQ29616391
A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia.Q33182502
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemiaQ33733461
Inactivation of LEF1 in T-cell acute lymphoblastic leukemiaQ33788690
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplificationQ33979941
Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemiaQ34131813
The TLX1 oncogene drives aneuploidy in T cell transformationQ34283329
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivationQ34283579
Molecular genetics of acute lymphoblastic leukemiaQ36254588
Reprogramming of T cells to natural killer-like cells upon Bcl11b deletionQ36772386
Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemiaQ37240046
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemiaQ37268926
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemiaQ38287709
Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.Q38304562
Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte developmentQ38304625
Activation of HOX11L2 by juxtaposition with 3'-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2).Q40660936
An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11bQ42227980
Haploinsufficiency and acquired loss of Bcl11b and H2AX induces blast crisis of chronic myelogenous leukemia in a transgenic mouse model.Q47828662
An essential developmental checkpoint for production of the T cell lineage.Q51905187
Cooperative genetic defects in TLX3 rearranged pediatric T-ALL.Q53506137
HOX11L2/TLX3 is transcriptionally activated through T-cell regulatory elements downstream of BCL11B as a result of the t(5;14)(q35;q32)Q57757938
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectlymphoblastic leukemiaQ18553852
leukemiaQ29496
acute T cell leukemiaQ18556895
P304page(s)4169-4173
P577publication date2011-08-30
P1433published inBloodQ885070
P1476titleThe BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia
P478volume118