| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2011PNAS..10818476J |
| P356 | DOI | 10.1073/PNAS.1112758108 |
| P932 | PMC publication ID | 3215008 |
| P698 | PubMed publication ID | 22042849 |
| P5875 | ResearchGate publication ID | 51760180 |
| P50 | author | William W Hauswirth | Q64478429 |
| P2093 | author name string | Li Jiang | |
| Jeanne M Frederick | |||
| Wolfgang Baehr | |||
| Houbin Zhang | |||
| Shannon E Boye | |||
| Alexander M Dizhoor | |||
| P2860 | cites work | Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily | Q22008807 |
| Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy. | Q24535806 | ||
| A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD) | Q24539234 | ||
| Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice | Q24670608 | ||
| A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1 | Q28118822 | ||
| Autosomal dominant cone and cone-rod dystrophy with mutations in the guanylate cyclase activator 1A gene-encoding guanylate cyclase activating protein-1 | Q28142044 | ||
| Current prospects for RNA interference-based therapies | Q28235733 | ||
| Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy | Q28256273 | ||
| Constitutive activation of photoreceptor guanylate cyclase by Y99C mutant of GCAP-1. Possible role in causing human autosomal dominant cone degeneration | Q28275397 | ||
| GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy | Q28279451 | ||
| Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors | Q28593705 | ||
| Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing | Q30465698 | ||
| RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells | Q30476196 | ||
| The Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice. | Q30764452 | ||
| Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. | Q30944070 | ||
| Increased light exposure alleviates one form of photoreceptor degeneration marked by elevated calcium in the dark | Q33521262 | ||
| GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice | Q34078737 | ||
| Suppression and replacement gene therapy for autosomal dominant disease in a murine model of dominant retinitis pigmentosa | Q34158497 | ||
| Role of guanylyl cyclase modulation in mouse cone phototransduction. | Q34189068 | ||
| Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. | Q34343088 | ||
| Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 | Q34764750 | ||
| Self-complementary AAV vectors; advances and applications | Q34804660 | ||
| Long-term preservation of cone photoreceptors and restoration of cone function by gene therapy in the guanylate cyclase-1 knockout (GC1KO) mouse. | Q35518971 | ||
| Gene therapy progress and prospects: the eye. | Q36534765 | ||
| Applications of RNA interference in mammalian systems. | Q36810329 | ||
| Bevasiranib for the treatment of wet, age-related macular degeneration | Q36867137 | ||
| A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy | Q36976213 | ||
| Hereditary retinal disease | Q37137469 | ||
| Constitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark. | Q37170561 | ||
| Barriers for retinal gene therapy: separating fact from fiction | Q37195446 | ||
| AAV retinal transduction in a large animal model species: comparison of a self-complementary AAV2/5 with a single-stranded AAV2/5 vector. | Q37346460 | ||
| Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application | Q37665303 | ||
| RNAi: a potential new class of therapeutic for human genetic disease | Q37871417 | ||
| Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy | Q39505058 | ||
| AAV-mediated knockdown of peripherin-2 in vivo using miRNA-based hairpins | Q43221778 | ||
| A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice | Q43252780 | ||
| Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene. | Q43262568 | ||
| Simple RNA enzymes with new and highly specific endoribonuclease activities | Q43501578 | ||
| Mutations in the GUCA1A gene involved in hereditary cone dystrophies impair calcium-mediated regulation of guanylate cyclase | Q45103610 | ||
| Assessment of ocular transduction using single-stranded and self-complementary recombinant adeno-associated virus serotype 2/8. | Q45399272 | ||
| Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection | Q45417238 | ||
| Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield | Q45747699 | ||
| Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. | Q45887309 | ||
| P433 | issue | 45 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | RNA interference | Q201993 |
| gene therapy | Q213901 | ||
| retinitis pigmentosa | Q847057 | ||
| P304 | page(s) | 18476-18481 | |
| P577 | publication date | 2011-10-31 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model | |
| P478 | volume | 108 |
| Q90298681 | Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa |
| Q35922370 | Calcium-myristoyl Tug is a new mechanism for intramolecular tuning of calcium sensitivity and target enzyme interaction for guanylyl cyclase-activating protein 1: dynamic connection between N-fatty acyl group and EF-hand controls calcium sensitivity |
| Q37732663 | Centrin 2 is required for mouse olfactory ciliary trafficking and development of ependymal cilia planar polarity |
| Q41979791 | Dysfunction of outer segment guanylate cyclase caused by retinal disease related mutations |
| Q57022617 | Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System |
| Q92301663 | Emerging Concepts for RNA Therapeutics for Inherited Retinal Disease |
| Q38169583 | Epigenetics and ocular diseases: from basic biology to clinical study |
| Q35172626 | Evaluating the role of retinal membrane guanylyl cyclase 1 (RetGC1) domains in binding guanylyl cyclase-activating proteins (GCAPs) |
| Q38754914 | Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein |
| Q35608125 | Heterotrimeric kinesin-2 (KIF3) mediates transition zone and axoneme formation of mouse photoreceptors |
| Q37683311 | Identification of target binding site in photoreceptor guanylyl cyclase-activating protein 1 (GCAP1). |
| Q36299855 | Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function |
| Q34254397 | Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies |
| Q31118763 | Production of cloned pigs with targeted attenuation of gene expression |
| Q38100997 | Progress in gene therapy for neurological disorders. |
| Q38207988 | RNA interference gene therapy in dominant retinitis pigmentosa and cone-rod dystrophy mouse models caused by GCAP1 mutations |
| Q34614424 | RNAi-mediated gene suppression in a GCAP1(L151F) cone-rod dystrophy mouse model |
| Q54377682 | RNAi-mediated knockdown of IKK1 in transgenic mice using a transgenic construct containing the human H1 promoter. |
| Q36012441 | Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors |
| Q38236675 | Retinal prosthetics, optogenetics, and chemical photoswitches |
| Q36104849 | Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors |
| Q28535090 | Structural insights for activation of retinal guanylate cyclase by GCAP1 |
| Q33844328 | Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones. |
| Q37165487 | cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function |
Search more.