Mutational spectrum of adult T-ALL

scientific article published on February 2015

Mutational spectrum of adult T-ALL is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.2218
P932PMC publication ID4413615
P698PubMed publication ID25595890
P5875ResearchGate publication ID270047913

P50authorDieter HoelzerQ15437636
Nicola GökbugetQ47158585
Monika BrüggemannQ87941467
Claudia D BaldusQ114529739
P2093author name stringJochen Hecht
Helmut Blum
Alexander Graf
Cornelia Schlee
Isabelle Bartram
Martin Neumann
Sandra Heesch
Stefan Schwartz
Stefan Krebs
Stefan K Bohlander
Philipp A Greif
Sebastian Vosberg
P2860cites workThe genetic basis of early T-cell precursor acute lymphoblastic leukaemiaQ24601515
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The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.Q27852046
Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.Q27852067
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PHF6 mutations in T-cell acute lymphoblastic leukemiaQ29394463
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NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) studyQ33395926
Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors.Q33558120
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemiaQ33733461
Inactivation of LEF1 in T-cell acute lymphoblastic leukemiaQ33788690
Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemiaQ33886181
Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemiaQ34131844
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesisQ34301317
Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.Q34324645
FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitorsQ34566158
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.Q34568855
T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)Q34612782
JAK/STAT signaling in hematological malignancies.Q34641224
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasmsQ34655449
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemiaQ34670390
Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemiasQ34973772
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemiaQ35483684
Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutationsQ35723764
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitorsQ36229551
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemiaQ36229601
Impact of deleterious passenger mutations on cancer progressionQ36637272
Clonal diversity of recurrently mutated genes in myelodysplastic syndromes.Q37078001
WT1 mutations in T-ALLQ37291631
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma.Q37318226
Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemiaQ37369925
Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions.Q37401075
Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignanciesQ37463690
Genetic lesions associated with chronic lymphocytic leukemia chemo-refractorinessQ37697850
Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia.Q37812860
Transcriptional drivers of the T-cell lineage programQ37977616
The molecular basis of T cell acute lymphoblastic leukemiaQ38047834
Early T-cell precursor acute lymphoblastic leukaemiaQ38108514
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemiaQ38287709
The role of the PTEN/AKT Pathway in NOTCH1-induced leukemiaQ39991646
Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemiaQ39999145
Risk/MRD adapted GMALL trials in adult ALL.Q40512939
Expression of the human homologue of rat NG2 in adult acute lymphoblastic leukemia: close association with MLL rearrangement and a CD10(-)/CD24(-)/CD65s(+)/CD15(+) B-cell phenotype.Q40571894
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemiaQ41296537
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemiaQ41911065
NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocolsQ42878950
Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL).Q44258484
Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutationsQ45860675
Treatment of adult acute lymphoblastic leukemiaQ46187922
Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.Q51549649
Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.Q52933515
Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALLQ56965918
Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL)Q58414406
MLL2 and KDM6A mutations in patients with Kabuki syndromeQ59697631
Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemiaQ61774820
NOTCH mutations as prognostic markers in T-ALLQ82884569
High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantationQ84470178
JAK1 mutations are not frequent events in adult T-ALL: a GRAALL studyQ84572720
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)2754-2766
P577publication date2015-02-01
P1433published inOncotargetQ1573155
P1476titleMutational spectrum of adult T-ALL
P478volume6

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