Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity

scientific article published on 14 September 2011

Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2011-04-351742
P932PMC publication ID3217355
P698PubMed publication ID21921047
P5875ResearchGate publication ID51645822

P50authorMartín E Fernández-ZapicoQ90465732
P2093author name stringLuciana L Almada
Anne J Novak
Stephen M Ansell
Thomas E Witzig
Lucy S Hodge
Deanna M Grote
Sherine F Elsawa
Steven C Ziesmer
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Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myelomaQ28248800
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor componentsQ28257845
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivoQ28609356
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuliQ29618769
Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells.Q31983538
GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.Q35065222
Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's MacroglobulinemiaQ35116840
Hyperviscosity syndrome in plasma cell dyscrasiasQ35590486
Bone marrow microenvironment and the identification of new targets for myeloma therapyQ36162703
Long-term culture of human bone marrow cellsQ36402575
Mechanisms of disease: regulation of RANTES (CCL5) in renal diseaseQ36745404
Cytokines in the microenvironment of Waldenström's macroglobulinemia.Q36783925
Multiple myeloma: a prototypic disease model for the characterization and therapeutic targeting of interactions between tumor cells and their local microenvironmentQ36839270
Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implicationsQ37201984
The microenvironment in mature B-cell malignancies: a target for new treatment strategiesQ37563816
Interleukin 6/interleukin 6 receptor interaction and its role as a therapeutic target for treatment of cachexia and cancerQ37820802
Blocking interleukin-1β in acute and chronic autoinflammatory diseasesQ37821071
Inflammatory signals regulate hematopoietic stem cellsQ37828295
Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stageQ37845554
Establishment of BCWM.1 cell line for Waldenström's macroglobulinemia with productive in vivo engraftment in SCID-hu mice.Q40087182
Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cellsQ40223980
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemiaQ40348403
Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathwayQ40373169
Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cellsQ40490939
Serum levels of IL-6 and its soluble receptor (sIL-6R) in Waldenström's macroglobulinemia.Q40728277
Transcriptional regulation of the interleukin-6 gene in mesangial cellsQ40942132
Involvement of Stat3 in interleukin-6-induced IgM production in a human B-cell lineQ41121963
Mechanisms of inhibition of IL-6-mediated immunoglobulin secretion by dexamethasone and suramin in human lymphoid and myeloma cell linesQ41208928
Development and characterization of a human marrow stromal cell line that enhances osteoclast-like cell formationQ41357481
Immunoglobulin secretion and phosphorylation of common proteins are induced by IL-2, IL-4, and IL-6 in the factor responsive human B cell line, SKW6.4.Q41508886
Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions.Q42520173
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applicationsQ43830963
Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic targetQ46202182
Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cellsQ48000642
Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation.Q52196589
Extended rituximab therapy in Waldenström's macroglobulinemia.Q53876960
Serum concentrations of angiogenic cytokines in Waldenstrom macroglobulinaemia: the ratio of angiopoietin-1 to angiopoietin-2 and angiogenin correlate with disease severityQ57904812
Abnormal bone remodelling and increased levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) in Waldenstrom macroglobulinaemiaQ57904835
Treatment of Waldenstrom's Macroglobulinemia with Rituximab: Prognostic Factors for Response and ProgressionQ57904975
Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NF-kappa B but not C/EBP beta or c-JunQ64380214
Smouldering Waldenstrom's macroglobulinemia: Factors predicting evolution to symptomatic diseaseQ73329249
Rituximab therapy in Waldenstrom's macroglobulinemia: preliminary evidence of clinical activityQ73374303
Cell-specific differences in the regulation of IL-6 expression by PMAQ77994869
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)5540-5549
P577publication date2011-09-14
P1433published inBloodQ885070
P1476titleComprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity
P478volume118

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