Future medical applications of single-cell sequencing in cancer

scientific article published on 31 May 2011

Future medical applications of single-cell sequencing in cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1010593159
P356DOI10.1186/GM247
P932PMC publication ID3219072
P698PubMed publication ID21631906
P5875ResearchGate publication ID51183216

P2093author name stringJames Hicks
Nicholas Navin
P2860cites workCancer as an evolutionary and ecological processQ22122026
Hallmarks of Cancer: The Next GenerationQ22252312
Isolation of rare circulating tumour cells in cancer patients by microchip technologyQ24597164
Distant metastasis occurs late during the genetic evolution of pancreatic cancerQ24624284
Complex landscapes of somatic rearrangement in human breast cancer genomesQ24631412
mRNA-Seq whole-transcriptome analysis of a single cellQ28240611
I-SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapyQ28244849
Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosisQ28280822
Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseasesQ28289395
Molecular definition of breast tumor heterogeneityQ28292256
Real-time DNA sequencing from single polymerase moleculesQ28301519
Genome remodelling in a basal-like breast cancer metastasis and xenograftQ28395637
Tumour evolution inferred by single-cell sequencingQ28646966
Inferring tumor progression from genomic heterogeneityQ28749457
Comprehensive human genome amplification using multiple displacement amplificationQ29618737
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolutionQ29619477
Intratumoral heterogeneity in breast carcinoma revealed by laser-microdissection and comparative genomic hybridizationQ30673310
Use of whole genome amplification and comparative genomic hybridisation to detect chromosomal copy number alterations in cell line material and tumour tissue.Q31082813
High resolution array-CGH analysis of single cellsQ33267061
Mechanism of chimera formation during the Multiple Displacement Amplification reactionQ33281958
Whole genome amplification and its impact on CGH array profiles.Q33360956
Molecular analysis of multifocal prostate cancer by comparative genomic hybridizationQ33368128
Approaching solid tumor heterogeneity on a cellular basis by tissue proteomics using laser capture microdissection and biological mass spectrometryQ33418010
Personalized copy number and segmental duplication maps using next-generation sequencing.Q33498358
Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotypeQ33604942
CNAseg--a novel framework for identification of copy number changes in cancer from second-generation sequencing data.Q33725108
Detection and removal of biases in the analysis of next-generation sequencing readsQ33815482
Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.Q34104724
Cytogenetic manifestations of multiple myeloma heterogeneityQ34360608
Heterogeneity of chromosome 17 and erbB-2 gene copy number in primary and metastatic bladder cancerQ34367966
Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH.Q34373539
Genetic clonal diversity predicts progression to esophageal adenocarcinomaQ34505745
Intra-tumour genetic heterogeneity and poor chemoradiotherapy response in cervical cancer.Q34543718
Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastasesQ34556958
Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysisQ34619418
Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cellsQ35129565
Novel patterns of genome rearrangement and their association with survival in breast cancerQ35173695
Single-cell PCR analysis of T helper cells in human lymph node germinal centersQ35809870
Interphase cytogenetics reveals a high incidence of aneuploidy and intra-tumour heterogeneity in breast cancer.Q36081862
High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancerQ36465618
High-resolution array comparative genomic hybridization of single micrometastatic tumor cells.Q36633194
Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issuesQ36930838
High-resolution mapping of copy-number alterations with massively parallel sequencingQ37072451
Whole genome amplification from a single cell: implications for genetic analysisQ37081188
DNA Sudoku--harnessing high-throughput sequencing for multiplexed specimen analysisQ37247014
Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arraysQ37318486
New technologies for the detection of circulating tumour cellsQ37736981
How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicineQ37793837
Breast cancer assessment tools and optimizing adjuvant therapy.Q37803121
ERCC5 is a novel biomarker of ovarian cancer prognosisQ38289922
Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneityQ38308859
Using next-generation sequencing for high resolution multiplex analysis of copy number variation from nanogram quantities of DNA from formalin-fixed paraffin-embedded specimensQ38416233
Homogeneity and heterogeneity in pancreas cancer: presence of predominant and minor morphological types and implicationsQ39686612
Tumor heterogeneity in lung cancer based on light microscopic features. A retrospective study of a consecutive series of 200 patients, treated surgicallyQ41452679
Whole genome amplification for array comparative genomic hybridization using DNA extracted from formalin-fixed, paraffin-embedded histological sectionsQ41769497
Chromosomal imbalances in primary and metastatic pancreatic carcinoma as detected by interphase cytogenetics: basic findings and clinical aspectsQ42089367
Genetic heterogeneity and clonal evolution in neuroblastoma.Q42137220
Ductal carcinoma in situ and the emergence of diversity during breast cancer evolutionQ42524058
Sensitive and accurate detection of copy number variants using read depth of coverageQ42566509
Single circulating tumor cell detection and overall survival in nonmetastatic breast cancerQ43256496
Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experienceQ43703303
Evaluation and significance of circulating epithelial cells in patients with hormone-refractory prostate cancerQ44367943
Characteristics associated with recurrence among women with ductal carcinoma in situ treated by lumpectomyQ46137363
Intratumoral heterogeneity of HER2/neu expression and its consequences for the management of advanced breast cancerQ46755338
Genotypic intratumoral heterogeneity in breast carcinoma with HER2/neu amplification: evaluation according to ASCO/CAP criteria.Q48001325
Evaluation of Phi29-based whole-genome amplification for microarray-based comparative genomic hybridisation.Q51773510
PSA and beyond: the past, present, and future of investigative biomarkers for prostate cancer.Q51789440
Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones.Q52050424
Prognostic significance of a grading system considering tumor heterogeneity in muscle-invasive urothelial carcinoma of the urinary bladder.Q53290873
Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer.Q53479490
Clone heterogeneity in diploid and aneuploid breast carcinomas as detected by FISH.Q54017054
Bar-coded, multiplexed sequencing of targeted DNA regions using the Illumina Genome Analyzer.Q54394341
Cytogenetic investigation of testicular carcinoma in situ and early seminoma by high-resolution comparative genomic hybridization analysis of subpopulations flow sorted according to DNA content.Q54724729
Intratumoral genetic heterogeneity in pilocytic astrocytomas revealed by CGH-analysis of microdissected tumor cells and FISH on tumor tissue sections.Q55470679
Cytogenetic and flow cytometry DNA analysis of regional heterogeneity in a low grade human glioma.Q55480905
Clonal heterogeneity in breast cancer: Karyotypic comparisons of multiple intra—and extra—tumorous samples from 3 patientsQ62583461
Karyotypic comparisons of multiple tumorous and macroscopically normal surrounding tissue samples from patients with breast cancerQ71079815
Chromosome analysis of 97 primary breast carcinomas: identification of eight karyotypic subgroupsQ71688238
Lumpectomy compared with lumpectomy and radiation therapy for the treatment of intraductal breast cancerQ72733504
Intratumoral nuclear morphologic heterogeneity in prostate cancerQ73249807
Radiotherapy in breast-conserving treatment for ductal carcinoma in situ: first results of the EORTC randomised phase III trial 10853. EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy GroupQ73465824
Molecular analysis of the immunoglobulin VH gene rearrangement in a primary cutaneous immunoblastic B-cell lymphoma by micromanipulation and single-cell PCRQ73775331
Aneuploidy of chromosome 8 as detected by interphase fluorescence in situ hybridization is a recurrent finding in primary and metastatic breast cancerQ74576633
Flow cytometry--principles and feasibility in transfusion medicine. Enumeration of epithelial derived tumor cells in peripheral bloodQ77092310
The genetics of cancer--a 3D modelQ77895897
Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA)Q79611680
Intratumoral heterogeneity of HER2/neu in breast cancer--a rare eventQ79825280
Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancerQ81199589
Detection of CK-19 mRNA-positive cells in the peripheral blood of breast cancer patients with histologically and immunohistochemically negative axillary lymph nodesQ81313462
Circulating melanoma cells and survival in metastatic melanomaQ83130894
Genetic heterogeneity in HER2 testing in breast cancer: panel summary and guidelinesQ83722585
HE4: a new potential early biomarker for the recurrence of ovarian cancerQ83970096
Predictive and prognostic value of peripheral blood cytokeratin-19 mRNA-positive cells detected by real-time polymerase chain reaction in node-negative breast cancer patientsQ83978338
P433issue5
P304page(s)31
P577publication date2011-05-31
P1433published inGenome MedicineQ15816848
P1476titleFuture medical applications of single-cell sequencing in cancer
P478volume3

Reverse relations

cites work (P2860)
Q34423694A new toolbox for assessing single cells
Q34794604A robust method to analyze copy number alterations of less than 100 kb in single cells using oligonucleotide array CGH.
Q27004390Advances and applications of single-cell sequencing technologies
Q30762666An assessment of computational methods for estimating purity and clonality using genomic data derived from heterogeneous tumor tissue samples
Q37418714Anti-invasive and anti-adhesive activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis).
Q35135586Application of Next Generation Sequencing for personalized medicine for sudden cardiac death
Q38254752Beyond genome sequencing: lineage tracking with barcodes to study the dynamics of evolution, infection, and cancer.
Q43241304Broad applications of single-cell nucleic acid analysis in biomedical research.
Q34537690Cancer genomic research at the crossroads: realizing the changing genetic landscape as intratumoral spatial and temporal heterogeneity becomes a confounding factor
Q58132668Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity
Q38124901Colorectal cancer diagnostics: biomarkers, cell-free DNA, circulating tumor cells and defining heterogeneous populations by single-cell analysis
Q39157332Comparable cytological features between cells processed as either wet mount or conventional cytospins
Q43045779DNA polymerases in biotechnology
Q38068927Deciphering the single-cell omic: innovative application for translational medicine.
Q53178108Detection of Activating Estrogen Receptor Gene (ESR1) Mutations in Single Circulating Tumor Cells.
Q48774676Deterministic trapping, encapsulation and retrieval of single-cells
Q35914897Emerging insights into the molecular and cellular basis of glioblastoma
Q90051151Environmental Carcinogenesis at the Single Cell Level
Q28678232Evolution of the cancer genome
Q53063636Expression of GRP78 predicts taxane-based therapeutic resistance and recurrence of human gastric cancer.
Q38778349Feasibility of a workflow for the molecular characterization of single cells by next generation sequencing
Q36534930Frontiers in Suicide Gene Therapy of Cancer
Q34395363Full-length RNA-seq from single cells using Smart-seq2.
Q39012815Genome evolution in ductal carcinoma in situ: invasion of the clones
Q36740913Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains
Q90644611Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Q28394818Getting personalized cancer genome analysis into the clinic: the challenges in bioinformatics
Q92934298Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset
Q38925555Heterogeneity of PIK3CA mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patients
Q89966162High-Throughput Transcriptome Profiling in Drug and Biomarker Discovery
Q34335350High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing.
Q30364660Highly multiplexed targeted DNA sequencing from single nuclei
Q38564005Inferring the Origin of Metastases from Cancer Phylogenies
Q27015460Investigating intratumour heterogeneity by single-cell sequencing
Q85908360Large (>3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous
Q37358959Long range personalized cancer treatment strategies incorporating evolutionary dynamics
Q27002964Making the genomic leap in HCT: application of second-generation sequencing to clinical advances in hematopoietic cell transplantation
Q51481422Microfluidic device for DNA amplification of single cancer cells isolated from whole blood by self-seeding microwells.
Q27340255Microfluidic enrichment for the single cell analysis of circulating tumor cells
Q96761949Molecular identification of Cryptococcus gattii from cerebrospinal fluid using single-cell sequencing: a case study
Q41225190Mutational analysis of single circulating tumor cells by next generation sequencing in metastatic breast cancer
Q38979961Next-generation molecular diagnosis: single-cell sequencing from bench to bedside
Q37989166Next-generation sequencing: ready for the clinics?
Q35114080Personalized medicine for gliomas
Q92940989Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma
Q30604285Precise pooling and dispensing of microfluidic droplets towards micro- to macro-world interfacing
Q35030496Precision platform for convex lens-induced confinement microscopy
Q59701596Primary immunodeficiency diseases in a tuberculosis endemic region: challenges and opportunities
Q64249042RNA Regulatory Networks as a Control of Stochasticity in Biological Systems
Q38159963Rapid translation of circulating tumor cell biomarkers into clinical practice: technology development, clinical needs and regulatory requirements
Q41430797Recent advances in molecular technologies and their application in pathogen detection in foods with particular reference to yersinia
Q36723382Resolving rates of mutation in the brain using single-neuron genomics
Q36161007Routing of Biomolecules and Transgenes' Vectors in Nuclei of Oocytes
Q51065126Scaling advantages and constraints in miniaturized capture assays for single cell protein analysis.
Q41713673SiFit: inferring tumor trees from single-cell sequencing data under finite-sites models
Q34239412Single cell genome sequencing
Q21563353Single cell genomics: advances and future perspectives
Q50062475Single cell on-chip whole genome amplification via micropillar arrays for reduced amplification bias.
Q37653489Single cell sequencing: a distinct new field
Q55311804Single cell transcriptome analysis of MCF-7 reveals consistently and inconsistently expressed gene groups each associated with distinct cellular localization and functions.
Q38631119Single circulating tumor cell sequencing as an advanced tool in cancer management
Q47557398Single-Cell Genomic Analysis in Plants.
Q26744582Single-Cell Sequencing Technology in Oncology: Applications for Clinical Therapies and Research
Q38851185Single-cell analysis: Advances and future perspectives
Q30453107Single-cell paired-end genome sequencing reveals structural variation per cell cycle
Q52901157Single-cell sequencing in cancer research.
Q27336129Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies
Q41883845Single-cell transcriptome in the identification of disease biomarkers: opportunities and challenges
Q34743417Single-cell, genome-wide sequencing identifies clonal somatic copy-number variation in the human brain
Q36503165TRA-1-60(+), SSEA-4(+), Oct4A(+), Nanog(+) Clones of Pluripotent Stem Cells in the Embryonal Carcinomas of the Ovaries
Q37244501Technological advances in precision medicine and drug development
Q36799509The genomically mosaic brain: aneuploidy and more in neural diversity and disease
Q36849660The potential for liquid biopsies in the precision medical treatment of breast cancer
Q37900640The role of inflammation in the pathogenesis of lung cancer
Q37197845TrAp: a tree approach for fingerprinting subclonal tumor composition
Q64102949Translating insights into tumor evolution to clinical practice: promises and challenges
Q26744341Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance
Q27014117Tumor heterogeneity and resistance to EGFR-targeted therapy in advanced nonsmall cell lung cancer: challenges and perspectives
Q28066914Tumour Heterogeneity: The Key Advantages of Single-Cell Analysis
Q87370568Whole genome and transcriptome amplification: practicable tools for sustainable tissue biobanking?

Search more.