The potential for liquid biopsies in the precision medical treatment of breast cancer

scientific article published on March 2016

The potential for liquid biopsies in the precision medical treatment of breast cancer is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID4850125
P698PubMed publication ID27144060
P5875ResearchGate publication ID301897617

P50authorMostafa ElhodakyQ57656739
P2093author name stringJulie E Lang
Victoria A Forte
Anson Snow
Lily Tung
Dany K Barrak
P2860cites workInitial sequencing and analysis of the human genomeQ21045365
DNA sequencing with chain-terminating inhibitorsQ22066207
Finishing the euchromatic sequence of the human genomeQ22122488
Genome sequencing in microfabricated high-density picolitre reactorsQ24544260
Isolation of rare circulating tumour cells in cancer patients by microchip technologyQ24597164
Mutational Analysis of Circulating Tumor Cells Using a Novel Microfluidic Collection Device and qPCR AssayQ24608051
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkersQ24614672
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasisQ24626854
Circulating tumor cells: approaches to isolation and characterizationQ24631347
High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysisQ24634121
Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)Q24635921
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtypeQ24646090
Detection of circulating tumor cells in prostate cancer patients: methodological pitfalls and clinical relevanceQ24646761
A large genome center's improvements to the Illumina sequencing systemQ24656090
Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosisQ24798477
Emerging technologies for CTC detection based on depletion of normal cellsQ27009519
Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilitiesQ27345462
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Sequencing technologies - the next generationQ27860568
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsQ27860709
Molecular portraits of human breast tumoursQ28032461
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasisQ28131703
Double-stranded DNA in exosomes: a novel biomarker in cancer detectionQ28237711
Human genome sequencing using unchained base reads on self-assembling DNA nanoarraysQ28263829
Accurate multiplex polony sequencing of an evolved bacterial genomeQ28265850
A sequencing method based on real-time pyrophosphateQ28279786
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasisQ28283104
Next-generation DNA sequencing methodsQ28285066
Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseasesQ28289395
FISH-based determination of HER2 status in circulating tumor cells isolated with the microfluidic CEE™ platform.Q54540577
Cell-free tumor DNA in blood plasma as a marker for circulating tumor cells in prostate cancer.Q54769141
Free DNA in the serum of cancer patients and the effect of therapy.Q55492005
Cell-Free Plasma DNA during Peritoneal Dialysis and Hemodialysis and in Patients with Chronic Kidney DiseaseQ57557797
K-ras point mutation detection in lung cancer: comparison of two approaches to somatic mutation detection using ARMS allele-specific amplificationQ58068714
External quality assurance of circulating tumor cell enumeration using the CellSearch® system: A feasibility studyQ58282445
Detection and viability of tumor cells in peripheral blood stem cell collections from breast cancer patients using immunocytochemical and clonogenic assay techniquesQ72553950
Effects of blood-processing protocols on cell-free DNA quantification in plasmaQ73036135
Comparison of immunocytochemistry, reverse transcriptase polymerase chain reaction, and nucleic acid sequence-based amplification for the detection of circulating breast cancer cellsQ73207838
Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancerQ73469713
Detection of circulating tumor cells in blood using an optimized density gradient centrifugationQ73487731
The cytologic demonstration and significance of tumor cells in the mesenteric venous blood in patients with colorectal carcinomaQ73739804
P53 mutations in primary and metastatic tumors and circulating tumor cells from colorectal carcinoma patientsQ74352266
Circulating tumor cell clusters in the peripheral blood of colorectal cancer patientsQ77372876
Comparison of two density gradient centrifugation systems for the enrichment of disseminated tumor cells in bloodQ78582458
The clinical significance of circulating tumor cellsQ79680217
The clinical significance of circulating tumour cells in breast cancer and colorectal cancer patientsQ80531692
Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancerQ81199589
Circulating tumor cells in patients with breast cancer dormancyQ81208525
Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancerQ81483516
Evaluation of multiparameter flow cytometry for the detection of breast cancer tumor cells in blood samplesQ81511462
Prognostic significance of circulating tumour cells enumerated after filtration enrichment in early and metastatic breast cancer patientsQ82847059
Analysis of loss of heterozygosity in circulating DNAQ83694195
High independent prognostic and predictive value of circulating tumor cells compared with serum tumor markers in a large prospective trial in first-line chemotherapy for metastatic breast cancer patientsQ84277674
Circulating tumor cells: getting more from lessQ84524811
Next-generation, genome sequencing-based biomarkers: concerns and challenges for medical practiceQ84719462
Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomasQ85049473
Targeting Mutant AKT in CancerQ86715259
Analysis of next-generation genomic data in cancer: accomplishments and challengesQ28293359
The origin of the Haitian cholera outbreak strainQ28300132
Real-time DNA sequencing from single polymerase moleculesQ28301519
Product differentiation by analysis of DNA melting curves during the polymerase chain reactionQ28305051
Tumour evolution inferred by single-cell sequencingQ28646966
Molecular biomarker analyses using circulating tumor cellsQ28749394
Kinetic PCR Analysis: Real-time Monitoring of DNA Amplification ReactionsQ29395822
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisitedQ29547915
Analysis of circulating tumor DNA to monitor metastatic breast cancerQ29614797
Detection of mutations in EGFR in circulating lung-cancer cellsQ29615033
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal compositionQ29615853
Real time quantitative PCRQ29616373
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through METQ29618139
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNAQ29620083
In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells.Q30454393
In vivo, noninvasive, label-free detection and eradication of circulating metastatic melanoma cells using two-color photoacoustic flow cytometry with a diode laserQ30479108
A simple biological imaging system for detecting viable human circulating tumor cellsQ30490534
Isolation of circulating tumor cells using a microvortex-generating herringbone-chipQ30497257
Isolation and retrieval of circulating tumor cells using centrifugal forces.Q30535350
Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient dataQ30779447
Detection of circulating melanoma cells in human blood using photoacoustic flowmetryQ30958715
A rare-cell detector for cancerQ31092483
Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: correlation with real-time reverse transcriptase-polymerase chain reaction results and feasibility of molecular analysis by laser microdissectionQ33245050
Monitoring the response of circulating epithelial tumor cells to adjuvant chemotherapy in breast cancer allows detection of patients at risk of early relapseQ33322711
Detection of circulating tumour cells in peripheral blood with an automated scanning fluorescence microscopeQ33358010
A comparison of RNA amplification techniques at sub-nanogram input concentrationQ33484382
Circulating tumor cells are transcriptionally similar to the primary tumor in a murine prostate modelQ33507492
Detection of circulating tumor cells in breast cancer may improve through enrichment with anti-CD146.Q33551239
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage.Q33590850
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma.Q33663019
Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancerQ33667666
Confocal images of circulating tumor cells obtained using a methodology and technology that removes normal cellsQ33691179
PIK3CA Mutations May Be Discordant between Primary and Corresponding Metastatic Disease in Breast CancerQ33715936
Assessment of a six gene panel for the molecular detection of circulating tumor cells in the blood of female cancer patients.Q33762644
Genomic profiling of isolated circulating tumor cells from metastatic breast cancer patientsQ33857819
Circulating tumor cells predict survival in early average-to-high risk breast cancer patientsQ33958981
Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular OncologyQ35584856
The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy.Q35681975
Genomic analysis of circulating cell-free DNA infers breast cancer dormancyQ35694373
Circulating breast cancer cells are frequently apoptoticQ35746628
Sensitive sequencing method for KRAS mutation detection by PyrosequencingQ35789986
Single-Molecule Sequencing Reveals Estrogen-Regulated Clinically Relevant lncRNAs in Breast Cancer.Q35795043
The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patientsQ35800375
A microfluidic device for label-free, physical capture of circulating tumor cell clustersQ35812039
MicroRNAs in apoptosis, autophagy and necroptosisQ35832148
Aberrant plasma levels of circulating miR-16, miR-107, miR-130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patientsQ35955325
Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors.Q36071451
Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA.Q36145554
Pyrosequencing: history, biochemistry and futureQ36258365
A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic AdenocarcinomaQ36437111
Role of HER2 mutations in refractory metastatic breast cancers: targeted sequencing results in patients with refractory breast cancerQ36544757
High-resolution array comparative genomic hybridization of single micrometastatic tumor cells.Q36633194
Interactive analysis and assessment of single-cell copy-number variationsQ36642284
Circulating nucleic acids (CNAs) and cancer--a surveyQ36669780
Tumour exosome integrins determine organotropic metastasis.Q36677568
EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-lowQ36689065
Pyrosequencing applicationsQ36690952
Organotropism of breast cancer metastasisQ36848841
Tumor cell dissemination: emerging biological insights from animal models and cancer patientsQ36887350
Prognostic impact of circulating tumor cells assessed with the CellSearch System™ and AdnaTest Breast™ in metastatic breast cancer patients: the DETECT studyQ36924426
Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patientsQ36955133
Significance of micrometastasis in bone marrow and blood of operable breast cancer patients: research tool or clinical application?Q36974719
Pyrosequencing for discovery and analysis of DNA sequence variationsQ36989849
Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells.Q37090760
Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper deviceQ37104899
Detection, clinical relevance and specific biological properties of disseminating tumour cellsQ37135356
Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells.Q37140168
Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer.Q37206520
Quantitative RT-PCR detection of colorectal tumor cells in peripheral blood--a systematic reviewQ37214063
Circulating tumor cells and bone marrow micrometastasisQ37242269
3D microfilter device for viable circulating tumor cell (CTC) enrichment from bloodQ37259934
Full-length cytokeratin-19 is released by human tumor cells: a potential role in metastatic progression of breast cancerQ37277185
Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cellsQ37360230
Prognostic impact of discordance between triple-receptor measurements in primary and recurrent breast cancerQ37468681
Isolation of circulating epithelial and tumor progenitor cells with an invasive phenotype from breast cancer patientsQ37480512
Exosomes: proteomic insights and diagnostic potentialQ37505058
Detection and prognostic significance of circulating tumour cells in patients with metastatic breast cancer according to immunohistochemical subtypesQ37507435
Genetic prognostic and predictive markers in colorectal cancerQ37523207
Circulating tumor cells: clinically relevant molecular access based on a novel CTC flow cellQ37529377
Optimization of an enrichment process for circulating tumor cells from the blood of head and neck cancer patients through depletion of normal cellsQ37531679
Circulating and disseminated tumor cells in the management of breast cancerQ37552483
Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chipQ37569045
Micrometastatic disease and metastatic outgrowth: clinical issues and experimental approaches.Q37605872
Next-generation sequencing-based multigene mutational screening for acute myeloid leukemia using MiSeq: applicability for diagnostics and disease monitoringQ37618897
Recent advances in the molecular characterization of circulating tumor cellsQ37693504
Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancerQ37721802
Epithelial-to-mesenchymal transitions and circulating tumor cellsQ37744737
Treatment of non-small-cell lung cancer with erlotinib or gefitinibQ37851148
Comprehensive next-generation cancer genome sequencing in the era of targeted therapy and personalized oncologyQ37886990
Isolation of rare circulating tumor cells in cancer patients: technical aspects and clinical implicationsQ37894736
Circulating tumor cells and circulating tumor DNA.Q37952771
Plasticity of disseminating cancer cells in patients with epithelial malignanciesQ38021683
Opportunities and challenges associated with clinical diagnostic genome sequencing: a report of the Association for Molecular Pathology.Q38037294
Circulating tumor cells and DNA as liquid biopsies.Q38133673
Real-time liquid biopsy in cancer patients: fact or fiction?Q38154437
Detection of micrometastasis by cytokeratin 20 RT-PCR is limited due to stable background transcription in granulocytesQ38273567
SSA-MOA: a novel CTC isolation platform using selective size amplification (SSA) and a multi-obstacle architecture (MOA) filterQ38461768
Is the NCI MATCH trial a match for gynecologic oncology?Q38639549
Frequent expression of PD-L1 on circulating breast cancer cellsQ38861829
Heterogeneity of PIK3CA mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patientsQ38925555
Apoptotic circulating tumor cells in early and metastatic breast cancer patientsQ39137881
M30 neoepitope expression in epithelial cancer: quantification of apoptosis in circulating tumor cells by CellSearch analysis.Q39639547
A cancer detection platform which measures telomerase activity from live circulating tumor cells captured on a microfilterQ39675091
Application of a filtration- and isolation-by-size technique for the detection of circulating tumor cells in cutaneous melanomaQ39695115
Artificial neural network analysis of circulating tumor cells in metastatic breast cancer patientsQ39734908
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer.Q39751877
Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cellsQ40121443
Application of immunomagnetic cell enrichment in combination with RT-PCR for the detection of rare circulating head and neck tumor cells in human peripheral bloodQ40186258
Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer.Q40280975
Detection and quantification of circulating tumor cells in mouse models of human breast cancer using immunomagnetic enrichment and multiparameter flow cytometryQ40438772
Whole-genome bisulfite sequencing of cell-free DNA identifies signature associated with metastatic breast cancer.Q40528885
Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. establishment of objective criteria for the evaluation of immunostained cellsQ40830360
Detection of tumor cells in the bone marrow, peripheral blood, and apheresis products of breast cancer patients using flow cytometryQ41306536
Therapeutic intervention based on circulating tumor cell phenotype in metastatic breast cancer: concept of the DETECT study programQ41382683
Nucleic acid-based methods for the detection of cancerQ41628883
Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reactionQ41656564
Feasibility study of red blood cell debulking by magnetic field-flow fractionation with step-programmed flow.Q42001928
Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabineQ42882313
DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells.Q43540280
Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencingQ46302330
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencingQ47163678
Meta-analysis of the prognostic value of circulating tumor cells in breast cancerQ47240978
Effects of preanalytical factors on the molecular size of cell-free DNA in bloodQ47391984
Pyrophosphorolysis-activated polymerization (PAP): application to allele-specific amplificationQ47585367
Circulating tumour cells in non-metastatic breast cancer: a prospective studyQ47652073
Man-made cell-like compartments for molecular evolutionQ47857062
Case study of the morphologic variation of circulating tumor cells.Q51091573
BEAMing up for detection and quantification of rare sequence variants.Q51283236
Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients.Q51507853
Clinical evaluation of a novel microfluidic device for epitope-independent enrichment of circulating tumour cells in patients with small cell lung cancer.Q51630365
Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer.Q51744140
Circulating tumor cells (CTCs) in metastatic breast cancer (MBC): prognosis, drug resistance and phenotypic characterization.Q53314502
Leaving home early: reexamination of the canonical models of tumor progression.Q53317126
Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer.Q53479490
Microdevice for the isolation and enumeration of cancer cells from blood.Q53510889
Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing.Q54239061
Genomes for all.Q33993431
Tracing the tumor lineageQ33998432
High fragmentation characterizes tumour-derived circulating DNA.Q34016528
About the possible origin and mechanism of circulating DNA apoptosis and active DNA releaseQ34100424
Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasisQ34111187
CD49f-based selection of circulating tumor cells (CTCs) improves detection across breast cancer subtypesQ34112732
Cell-free nucleic acids as biomarkers in cancer patientsQ34184393
Landscape of next-generation sequencing technologies.Q34187217
Towards standardisation of cell-free DNA measurement in plasma: controls for extraction efficiency, fragment size bias and quantificationQ34277946
Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA.Q34278191
Alta-Cyclic: a self-optimizing base caller for next-generation sequencingQ34299405
NanoVelcro Chip for CTC enumeration in prostate cancer patientsQ34354738
The Long-HER study: clinical and molecular analysis of patients with HER2+ advanced breast cancer who become long-term survivors with trastuzumab-based therapy.Q34373936
Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500Q34402487
Circulating tumor DNA as a liquid biopsy for cancerQ34447436
A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screeningQ34492755
Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancerQ34500359
KRAS and BRAF mutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissueQ34509268
MiR-27 as a prognostic marker for breast cancer progression and patient survivalQ34512567
Molecular profiling of single circulating tumor cells with diagnostic intentionQ34542660
Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progressionQ34655105
Cellular image analysis and imaging by flow cytometryQ34656668
The significance of circulating epithelial cells in Breast Cancer patients by a novel negative selection methodQ34722580
Transitions between epithelial and mesenchymal states in development and diseaseQ34761972
Is there a role for circulating tumor cells in the management of breast cancer?Q34786955
Cancer micrometastasesQ34978121
Evaluation of proliferation and apoptosis markers in circulating tumor cells of women with early breast cancer who are candidates for tumor dormancy.Q35000713
Influence of plasma processing on recovery and analysis of circulating nucleic acidsQ35035846
Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.Q35174681
Assessment of EGFR mutations in circulating tumor cell preparations from NSCLC patients by next generation sequencing: toward a real-time liquid biopsy for treatmentQ35227986
Insight into the heterogeneity of breast cancer through next-generation sequencingQ35370090
Enhanced ratio of signals enables digital mutation scanning for rare allele detectionQ35543098
Future medical applications of single-cell sequencing in cancerQ35558519
P433issue1
P304page(s)19-40
P577publication date2016-03-01
P1433published inCancer Biology & MedicineQ26841841
P1476titleThe potential for liquid biopsies in the precision medical treatment of breast cancer
P478volume13

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cites work (P2860)
Q57474043ASO Author Reflections: The Whole Transcriptome Landscape of Circulating Tumor Cells in Nonmetastatic Breast Cancer
Q55078140Challenges in using liquid biopsies for gene expression profiling.
Q55053015Changes of KEAP1/NRF2 and IKB/NF-κB Expression Levels Induced by Cell-Free DNA in Different Cell Types.
Q28067549Dissecting the Heterogeneity of Circulating Tumor Cells in Metastatic Breast Cancer: Going Far Beyond the Needle in the Haystack
Q40971199Expression of guanylyl cyclase C in tissue samples and the circulation of rectal cancer patients
Q38621053Molecular characterization and heterogeneity of circulating tumor cells in breast cancer.
Q57490805SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression

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