Frontiers in Suicide Gene Therapy of Cancer

scientific article published on October 2012

Frontiers in Suicide Gene Therapy of Cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4172/2157-7412.1000E114
P932PMC publication ID3545697
P698PubMed publication ID23330070

P2093author name stringMarek Malecki
P2860cites workMicroRNA profiling of a CD133(+) spheroid-forming subpopulation of the OVCAR3 human ovarian cancer cell lineQ21202160
Emerging concepts in the immunopathogenesis of AIDSQ22241984
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumorsQ24652007
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatmentQ24656967
The natural history of EGFR and EGFRvIII in glioblastoma patientsQ24814477
Mucin-based targeted pancreatic cancer therapyQ26861761
Cancer statistics, 2010Q27860525
Identification and expansion of human colon-cancer-initiating cellsQ27860627
CD44 expression indicates favorable prognosis in epithelial ovarian cancerQ28183827
Efficacy of lentivirus-mediated and MUC1 antibody-targeted VP22-TK/GCV suicide gene therapy for ovarian cancer.Q40641602
Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyltransferase suicide systemQ40679193
Specific CEA-producing colorectal carcinoma cell killing with recombinant adenoviral vector containing cytosine deaminase gene.Q40741120
The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promotersQ40810330
Neuron specific enolase promoter for suicide gene therapy in small cell lung carcinoma.Q40813146
Adenovirus-mediated Bax overexpression for the induction of therapeutic apoptosis in prostate cancer.Q40825681
Prostate-specific suicide gene therapy using the prostate-specific membrane antigen promoter and enhancerQ40849909
Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slicesQ41833348
Adenovirus-mediated tissue-targeted expression of a caspase-9-based artificial death switch for the treatment of prostate cancerQ42510207
CD133 and CD44 cell surface markers do not identify cancer stem cells in primary human gastric tumorsQ43411083
Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancersQ43556296
Suicide gene therapy on LNCaP human prostate cancer cellsQ43666048
In vivo suicide gene therapy model using a newly discovered prostate-specific membrane antigen promoter/enhancer: a potential alternative approach to androgen deprivation therapyQ43705366
Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/5-fluorocytosine enhanced by the cre/loxP system in the orthotopic gastric carcinoma model.Q43708562
Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.Q43831003
Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killingQ43962720
Suicide gene therapy using keratin 19 enhancer and promoter in malignant mesothelioma cells.Q44009716
Suicide gene therapy for prostate cancer--update of current developmentQ44522976
The CD44 Receptor Is a Molecular Predictor of Survival in Ovarian CancerQ44558334
Treatment of ovarian cancer cell line Skov3 with HSV-tk/GCV under the control of human telomerase reverse transcriptase gene promoterQ44584823
Suicide gene therapy with HSV-TK in pancreatic cancer has no effect in vivo in a mouse model.Q44645371
Treatment efficiency of a suicide gene therapy using prostate-specific membrane antigen promoter/enhancer in a castrated mouse model of prostate cancerQ44836105
Adenoviral oncolytic suicide gene therapy for a peritoneal dissemination model of gastric cancer in miceQ45855727
In vivo gene transfer of a suicide gene under the transcriptional control of the carcinoembryonic antigen promoter results in bone marrow transduction but can avoid bone marrow suppressionQ45858941
Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapyQ45866314
Phase I trial of replication-competent adenovirus-mediated suicide gene therapy combined with IMRT for prostate cancerQ45866747
Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancerQ45867327
Side effects of suicide gene therapy.Q45870665
HIV vector-mediated targeted suicide gene therapy for adult T-cell leukemiaQ45871562
Selective targeting of genetically engineered mesenchymal stem cells to tumor stroma microenvironments using tissue-specific suicide gene expression suppresses growth of hepatocellular carcinomaQ45874553
Therapeutic effect of genetically modified human neural stem cells encoding cytosine deaminase on experimental gliomaQ45875949
Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancerQ45876190
Tumor tropism of intravenously injected human-induced pluripotent stem cell-derived neural stem cells and their gene therapy application in a metastatic breast cancer model.Q45876898
Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response.Q45879519
Prostate-specific expression of Bax delivered by an adenoviral vector induces apoptosis in LNCaP prostate cancer cellsQ45880055
Targeting of prostate cancer cells by a cytotoxic lentiviral vector containing a prostate stem cell antigen (PSCA) promoterQ45885785
CD133+CD44+ population efficiently enriches colon cancer initiating cellsQ46457938
Development of a genetically engineered biomimetic vector for targeted gene transfer to breast cancer cellsQ47871933
Human bone marrow-derived mesenchymal stem cells in the treatment of gliomasQ48926056
Tumor regression after systemic administration of transferrin-targeted TNFalpha plasmid-dendrimer conjugates.Q53478288
Isolation of single, intact chromosomes from single, selected ovarian cancer cells for in situ hybridization and sequencing.Q54334800
Highly enriched CD133(+)CD44(+) stem-like cells with CD133(+)CD44(high) metastatic subset in HCT116 colon cancer cells.Q54359849
Secretion of thymidine kinase to increase the effectivity of suicide gene therapy results in the loss of enzymatic activityQ64376841
Evaluation of the effects of androgen receptor gene trinucleotide repeats and prostate-specific antigen gene polymorphisms on prostate cancer.Q64904715
CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancerQ71805116
Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimensQ80099843
Isolation, characterization and mobilization of prostate cancer tissue derived CD133+ MDR1+ cellsQ82322235
Overview of gene delivery into cells using HSV-1-based vectorsQ85258572
Bystander killing effect of tymidine kinase gene-transduced adult bone marrow stromal cells with ganciclovir on malignant glioma cellsQ39673692
Glioblastoma cells negative for the anti-CD133 antibody AC133 express a truncated variant of the CD133 protein.Q39709460
Side populations of glioblastoma cells are less sensitive to HSV-TK/GCV suicide gene therapy system than the non-side populationQ39743190
Using lentiviral vectors for efficient pancreatic cancer gene therapyQ39775324
HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cellsQ39797615
Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancerQ39830274
Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen.Q39880360
Isolation and characterization of cancer stem like cells in human glioblastoma cell linesQ39881450
Enhanced combined tumor-specific oncolysis and suicide gene therapy for prostate cancer using M6 promoterQ39942987
Improved lentiviral transduction of human mesenchymal stem cells for therapeutic intervention in pancreatic cancerQ40023771
Development of a transferrin receptor-targeting HVJ-E vectorQ40062249
Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancerQ40123376
Expression of CD44v6 correlates with cell proliferation and cellular atypia in urothelial carcinoma cell lines 5637 and HT1197.Q40443721
Development of an inducible suicide gene system based on human caspase 8.Q40450767
Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas.Q40465928
Adenovirus-mediated suicide SCLC gene therapy using the increased activity of the hTERT promoter by the MMRE and SV40 enhancer.Q40467082
Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells.Q40481710
A neuroblastoma-selective suicide gene therapy approach using the tyrosine hydroxylase promoter.Q40548567
Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancerQ40593343
Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcomaQ40634758
Adenovirus-mediated suicide gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter induced apoptosis of ovarian cancer cell lineQ28188296
Identification and expansion of the tumorigenic lung cancer stem cell populationQ28259332
The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiationQ28270177
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5Q28303765
CXCR4 expression in prostate cancer progenitor cellsQ28480904
Using birth defects registry data to evaluate infant and childhood mortality associated with birth defects: an alternative to traditional mortality assessment using underlying cause of death statisticsQ31135734
The role of CD133 in the identification and characterisation of tumour-initiating cells in non-small-cell lung cancerQ33451434
Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapyQ33484184
Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy.Q33514643
Genetic risk assessments in individuals at high risk for inherited breast cancer in the breast oncology care settingQ33564013
Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targetingQ33740415
Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coatQ33870113
Combined MUC1-specific nanobody-tagged PEG-polyethylenimine polyplex targeting and transcriptional targeting of tBid transgene for directed killing of MUC1 over-expressing tumour cellsQ33942904
Cancer suicide gene therapy with TK.007: superior killing efficiency and bystander effectQ34027421
A designer biomimetic vector with a chimeric architecture for targeted gene transferQ34078983
Specific targeting strategies of cancer gene therapy using a single-chain variable fragment (scFv) with a high affinity for CEA.Q34115033
Suicide gene therapy with Herpes simplex virus thymidine kinase and ganciclovir is enhanced with connexins to improve gap junctions and bystander effectsQ34184994
Herpes virus fusion and entry: a story with many characters.Q34285628
Clinical trials of adenoviral-mediated suicide gene therapy of malignant gliomasQ34361481
CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patientsQ34370179
Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin.Q34462411
HSV-TK/GCV cancer suicide gene therapy by a designed recombinant multifunctional vectorQ34507776
Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase.Q34557622
Gene expression profiling of gliomas: merging genomic and histopathological classification for personalised therapy.Q34627868
Involvement of CD44, a molecule with a thousand faces, in cancer dissemination.Q34777492
Adaptive seamless design for an efficacy trial of replication-competent adenovirus-mediated suicide gene therapy and radiation in newly-diagnosed prostate cancer (ReCAP Trial)Q34855696
Incorporation of biomarker assessment in novel clinical trial designs: personalizing brain tumor treatmentsQ35161909
Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markersQ35169094
Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cellsQ35190005
Viral therapy for glioblastomaQ35210466
Gene therapy for human malignant brain tumors.Q35210470
Future medical applications of single-cell sequencing in cancerQ35558519
CD44v6: a target for antibody-based cancer therapyQ35648600
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vectorQ35696378
In vitro and in vivo double-enhanced suicide gene therapy mediated by generation 5 polyamidoamine dendrimers for PC-3 cell lineQ35768818
Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomasQ35827956
Clinical characteristics and outcomes of BRCA-associated ovarian cancer: genotype and survivalQ35914568
Identification of factors important for the success of suicide gene therapy after a comparative study of Varicella zoster and Herpes simplex viral thymidine kinases efficacy on breast cancer cells.Q36261074
Clinical trials of gene therapy, virotherapy, and immunotherapy for malignant gliomasQ36367428
OVARIAN CANCER SUICIDE GENE THERAPY WITH GENETICALLY ENGINEERED, TRANSGENICALLY EXPRESSED, INTRACELLULAR scFv ANTIBODIES AGAINST ANTI-OXIDATIVE ENZYMES.Q36460902
TRA-1-60(+), SSEA-4(+), Oct4A(+), Nanog(+) Clones of Pluripotent Stem Cells in the Embryonal Carcinomas of the OvariesQ36503165
In vivo gene transfer targeting in pancreatic adenocarcinoma with cell surface antigensQ36536212
Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivoQ37096766
Molecularly targeted therapies for malignant gliomas.Q37107374
Targeted therapies for malignant glioma: progress and potential.Q37159549
CD133 expression associated with poor prognosis in ovarian cancerQ37373712
The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patientsQ37475929
Glioblastoma stem cellsQ37831190
Management of malignant pleural effusion by suicide gene therapy in advanced stage lung cancer: a case series and literature review.Q38022486
In vivo characterization of a prostate-specific antigen promoter-based suicide gene therapy for the treatment of benign prostatic hyperplasiaQ38520136
Human embryonic stem cell-derived mesenchymal stem cells as cellular delivery vehicles for prodrug gene therapy of glioblastomaQ38888896
The anti-glioma effect of suicide gene therapy using BMSC expressing HSV/TK combined with overexpression of Cx43 in glioma cellsQ39084406
Human neural stem cells can target and deliver therapeutic genes to breast cancer brain metastasesQ39111100
Glioma gene therapy using induced pluripotent stem cell derived neural stem cellsQ39166287
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.Q39335846
Valproic acid enhances anti-tumor effect of mesenchymal stem cell mediated HSV-TK gene therapy in intracranial gliomaQ39360531
Bystander effect in suicide gene therapy using immortalized neural stem cells transduced with herpes simplex virus thymidine kinase gene on medulloblastoma regressionQ39370389
Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer.Q39386066
Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasionQ39413746
Suicidal gene therapy against tumor using reducible poly (oligo-D-arginine).Q39423134
Selective killing of lung cancer cells using carcinoembryonic antigen promoter and double suicide genes, thymidine kinase and cytosine deaminase (pCEA-TK/CD).Q39440479
Non-integrating lentiviral vectors for specific killing of Epstein-Barr virus nuclear antigen 1-positive B cell lymphoma cellsQ39488698
Nanoparticle-delivered VEGF-silencing cassette and suicide gene expression cassettes inhibit colon carcinoma growth in vitro and in vivoQ39506352
Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastomaQ39512141
Targeted suicide gene therapy for glioma using human embryonic stem cell-derived neural stem cells genetically modified by baculoviral vectors.Q39531933
Identification and functional characterization of glioma-specific promoters and their application in suicide gene therapyQ39586718
Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic propertiesQ39616065
Non-covalent association of folate to lipoplexes: a promising strategy to improve gene delivery in the presence of serumQ39636701
P433issue3
P921main subjectgene therapyQ213901
suicideQ10737
P577publication date2012-10-01
P1433published inJournal of genetic syndromes & gene therapyQ27723954
P1476titleFrontiers in Suicide Gene Therapy of Cancer
P478volume2012

Reverse relations

cites work (P2860)
Q38870602A Lentiviral Vector Expressing Desired Gene Only in Transduced Cells: An Approach for Suicide Gene Therapy
Q35109273Eradication of Human Ovarian Cancer Cells by Transgenic Expression of Recombinant DNASE1, DNASE1L3, DNASE2, and DFFB Controlled by EGFR Promoter: Novel Strategy for Targeted Therapy of Cancer
Q37366610Improved Adeno-associated Viral Gene Transfer to Murine Glioma.
Q59357946Inducible Caspase9-mediated suicide gene for MSC-based cancer gene therapy
Q38421345Killing of cancer cells through the use of eukaryotic expression vectors harbouring genes encoding nucleases and ribonuclease inhibitor
Q92081727LdrB Toxin with In Vitro and In Vivo Antitumor Activity as a Potential Tool for Cancer Gene Therapy
Q33920686Safeguarding Stem Cell-Based Regenerative Therapy against Iatrogenic Cancerogenesis: Transgenic Expression of DNASE1, DNASE1L3, DNASE2, DFFB Controlled By POLA1 Promoter in Proliferating and Directed Differentiation Resisting Human Autologous Plurip
Q33653485Stem cells' guided gene therapy of cancer: New frontier in personalized and targeted therapy
Q37347017Suicide Gene Therapy for Cancer - Current Strategies
Q35176800Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer.
Q41040429Using intron splicing trick for preferential gene expression in transduced cells: an approach for suicide gene therapy

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