Characterization of novel peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) isoform in human liver.

scientific article published on 18 October 2011

Characterization of novel peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) isoform in human liver. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M111.227496
P932PMC publication ID3234813
P698PubMed publication ID22009745
P5875ResearchGate publication ID51727500

P50authorGabriele GadermaierQ38320035
Richard WeissQ43375882
Thomas K FelderQ57631136
P2093author name stringWolfgang Patsch
Harald Esterbauer
Selma M Soyal
Hannes Oberkofler
Franz Krempler
Simon Auer
Karl Miller
Penelope Hahne
P2860cites workHuman peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expressionQ22010886
A tissue-specific coactivator of steroid receptors, identified in a functional genetic screenQ22253330
Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activationQ24309467
Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alphaQ24535642
PGC-1 coactivators: inducible regulators of energy metabolism in health and diseaseQ24541524
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPKQ24598689
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1Q24679555
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesisQ27860471
WebLogo: A Sequence Logo GeneratorQ27860646
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1Q28131760
Activation of PPARgamma coactivator-1 through transcription factor dockingQ28137806
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humansQ28191413
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1Q28216275
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1Q28237795
PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetesQ28244126
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotidesQ28250451
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolismQ28266830
Biological control through regulated transcriptional coactivatorsQ28287472
Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolismQ28508765
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesQ29547229
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibresQ29555845
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null miceQ29614547
Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humansQ29615184
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1Q29615692
Metabolic control through the PGC-1 family of transcription coactivatorsQ29616509
Genome-wide analysis of mammalian promoter architecture and evolutionQ29616717
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivatorsQ29617353
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interactionQ29619822
MODBASE, a database of annotated comparative protein structure models, and associated resources.Q30336561
rVISTA 2.0: evolutionary analysis of transcription factor binding sitesQ31081582
Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exerciseQ33338768
Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1.Q33885372
Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressorQ33933516
PROMO: detection of known transcription regulatory elements using species-tailored searchesQ34114282
Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulationQ34125867
Immune responses induced by intramuscular or gene gun injection of protective deoxyribonucleic acid vaccines that express the circumsporozoite protein from Plasmodium berghei malaria parasites.Q34464830
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesisQ34920348
DNA vaccines for allergy treatmentQ35667010
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.Q35720854
The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expressionQ35890670
Determinants of plasma apolipoprotein A-V and APOA5 gene transcripts in humansQ36496770
Mammalian RNA polymerase II core promoters: insights from genome-wide studiesQ36814333
The gene coding for PGC-1alpha modifies age at onset in Huntington's DiseaseQ37071213
Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alphaQ37432144
The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscleQ37482064
Tissue-specific splicing factor gene expression signaturesQ38288973
Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expressionQ38306001
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymesQ39451469
The activation function 2 domain of hepatic nuclear factor 4 is regulated by a short C-terminal proline-rich repressor domainQ39723698
Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells.Q39905162
A novel SREBP-1 splice variant: tissue abundance and transactivation potencyQ40375301
Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.Q40572878
Peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1 recruitment regulates PPAR subtype specificityQ40747393
PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cellsQ42478723
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosisQ42644245
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.Q44240302
Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetesQ44865559
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.Q45302702
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegenerationQ45302924
Tomio Tada 1934-2010.Q48461688
Hepatic adiponectin receptors (ADIPOR) 1 and 2 mRNA and their relation to insulin resistance in obese humans.Q53775867
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1αQ59066890
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alphaQ64377758
Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1Q73626496
P433issue50
P407language of work or nameEnglishQ1860
P1104number of pages14
P304page(s)42923-42936
P577publication date2011-10-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleCharacterization of novel peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) isoform in human liver
P478volume286

Reverse relations

cites work (P2860)
Q34275231A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset
Q58603892Aberrant expression of alternative isoforms of transcription factors in hepatocellular carcinoma
Q44177904Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis
Q36077931BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans
Q91687105Characterization of the hepatic transcriptome following phenobarbital induction in mice with AIP
Q34057855Endoplasmic reticulum stress links hepatitis C virus RNA replication to wild-type PGC-1α/liver-specific PGC-1α upregulation
Q54396964Exercise-induced expression of peroxisome proliferator-activated receptor γ coactivator-1α isoforms in skeletal muscle of endurance-trained males.
Q92582820Mitochondrial regulator PGC-1a-Modulating the modulator
Q50212482Overexpression of PGC-1α Influences Mitochondrial Signal Transduction of Dopaminergic Neurons
Q90378311PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
Q26752335PGC-1α, glucose metabolism and type 2 diabetes mellitus
Q38450914Regulation of PGC-1α Isoform Expression in Skeletal Muscles
Q40112761Role of HDAC9-FoxO1 Axis in the Transcriptional Program Associated with Hepatic Gluconeogenesis.
Q93025892The Expression of CNS-Specific PPARGC1A Transcripts Is Regulated by Hypoxia and a Variable GT Repeat Polymorphism
Q89896008The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases
Q38537381The hitchhiker's guide to PGC-1α isoform structure and biological functions
Q45302304mRNA expression levels of PGC-1α in a transgenic and a toxin model of Huntington's disease.