scholarly article | Q13442814 |
P50 | author | Adam D Richardson | Q55130332 |
Gary G. Chiang | Q55130333 | ||
Fabian V. Filipp | Q55130334 | ||
P2093 | author name string | David A Scott | |
Ze'ev A Ronai | |||
Jeffrey W Smith | |||
Andrei L Osterman | |||
Christine A Knutzen | |||
P2860 | cites work | Main roads to melanoma | Q21245465 |
Understanding the Warburg effect: the metabolic requirements of cell proliferation | Q24604760 | ||
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate | Q24605258 | ||
GeneCards Version 3: the human gene integrator | Q24610308 | ||
Cluster analysis and display of genome-wide expression patterns | Q24644463 | ||
Human melanoma cells express functional receptors for thyroid-stimulating hormone | Q79422393 | ||
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia | Q28300406 | ||
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption | Q28300415 | ||
Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival | Q28476795 | ||
Java Treeview--extensible visualization of microarray data | Q29547226 | ||
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity | Q29616651 | ||
On respiratory impairment in cancer cells | Q29617276 | ||
Otto Warburg's contributions to current concepts of cancer metabolism | Q29617601 | ||
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis | Q29617613 | ||
The impact of O2 availability on human cancer | Q29619884 | ||
Determination of metabolic flux ratios from 13C-experiments and gas chromatography-mass spectrometry data: protocol and principles | Q31065954 | ||
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer | Q33604129 | ||
Quiescent fibroblasts exhibit high metabolic activity. | Q33737849 | ||
A role for ATF2 in regulating MITF and melanoma development | Q33784589 | ||
Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review | Q34028478 | ||
Deletion of genes encoding cytochrome oxidases and quinol monooxygenase blocks the aerobic-anaerobic shift in Escherichia coli K-12 MG1655. | Q34177720 | ||
Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells | Q34517790 | ||
Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin | Q34570988 | ||
Molecular imaging of cancer with positron emission tomography | Q34810431 | ||
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells | Q35008346 | ||
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth | Q35458543 | ||
Phosphatidylinositol-3-kinase as a therapeutic target in melanoma | Q35606261 | ||
Central carbon metabolism in the progression of mammary carcinoma | Q36738269 | ||
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression | Q37042015 | ||
Evidence for reverse flux through pyruvate kinase in skeletal muscle. | Q37162296 | ||
Melanoma: molecular pathogenesis and emerging target therapies (Review). | Q37474412 | ||
Rethinking the Warburg effect with Myc micromanaging glutamine metabolism | Q37677940 | ||
Targeting metabolic transformation for cancer therapy. | Q37714309 | ||
Targeting cancer metabolism: a therapeutic window opens | Q37924094 | ||
C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells | Q39954044 | ||
Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line | Q39998829 | ||
Metabolic and morphological differences between rapidly proliferating cancerous and normal breast epithelial cells | Q40007880 | ||
Comparative metabolomics of breast cancer. | Q40054731 | ||
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors | Q40444060 | ||
Cellular senescence in naevi and immortalisation in melanoma: a role for p16? | Q42016240 | ||
Ammonia derived from glutaminolysis is a diffusible regulator of autophagy | Q42470786 | ||
Correcting mass isotopomer distributions for naturally occurring isotopes | Q44153792 | ||
Mechanistic stoichiometry of mitochondrial oxidative phosphorylation | Q45036631 | ||
Acylic sugar derivatives for GC/MS analysis of 13C-enrichment during carbohydrate metabolism | Q45147529 | ||
Measurement of fractional lipid synthesis using deuterated water (2H2O) and mass isotopomer analysis | Q46583121 | ||
P433 | issue | 49 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | flux | Q5463013 |
P304 | page(s) | 42626-42634 | |
P577 | publication date | 2011-10-13 | |
P1433 | published in | Journal of Biological Chemistry | Q867727 |
P1476 | title | Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect | |
P478 | volume | 286 |
Q37004918 | (13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism |
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Q89791834 | A case of malignant hyperlactaemic acidosis appearing upon treatment with the mono-carboxylase transporter 1 inhibitor AZD3965 |
Q42269519 | A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds |
Q37326607 | Activated lymphocytes as a metabolic model for carcinogenesis. |
Q38439387 | Activity-Based Protein Profiling Shows Heterogeneous Signaling Adaptations to BRAF Inhibition |
Q91792367 | Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment |
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Q38961789 | Altered metabolite levels in cancer: implications for tumour biology and cancer therapy. |
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Q60709661 | Analysis of biologically-active, endogenous carboxylic acids based on chromatography-mass spectrometry |
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Q89989601 | FOXO3a‑SIRT6 axis suppresses aerobic glycolysis in melanoma |
Q43781559 | Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity. |
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Q38064856 | Germ cell proteins in melanoma: prognosis, diagnosis, treatment, and theories on expression |
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Q90074895 | Glucose Exerts an Anti-Melanogenic Effect by Indirect Inactivation of Tyrosinase in Melanocytes and a Human Skin Equivalent |
Q37622642 | Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. |
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Q27011818 | Glutamine and cancer: cell biology, physiology, and clinical opportunities |
Q38933788 | Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. |
Q36330223 | Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. |
Q38030652 | Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma. |
Q93187619 | HSF1: a mediator in metabolic alteration of hepatocellular carcinoma cells in cross-talking with tumor-associated macrophages |
Q39133952 | HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer |
Q64280878 | Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery |
Q36155710 | Human milk oligosaccharides promote the growth of staphylococci. |
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Q36948088 | IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism |
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Q38821977 | Influence of Serum and Hypoxia on Incorporation of [(14)C]-D-Glucose or [(14)C]-L-Glutamine into Lipids and Lactate in Murine Glioblastoma Cells. |
Q48544710 | Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin. |
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Q28069081 | Metabolic rewiring in melanoma |
Q47759599 | Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications. |
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Q38280740 | Metabolism and epigenetics: a link cancer cells exploit. |
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Q58728932 | Metformin: Focus on Melanoma |
Q38801510 | MicroRNA 211 Functions as a Metabolic Switch in Human Melanoma Cells |
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