Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells.

scientific article

Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1048758485
P356DOI10.1186/S12885-016-2185-5
P932PMC publication ID4763451
P698PubMed publication ID26907172
P5875ResearchGate publication ID295672427

P50authorAndreas BehrenQ39062050
Anderly C. ChuehQ42426472
Jonathan CebonQ64683306
Mercedes Dávalos-SalasQ85412101
P2093author name stringMatthew Anaka
Pu-Han Lo
Aparna Jayachandran
Prashanth Prithviraj
Ramyar Molania
Marzena Walkiewicz
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Mitochondrial respiration--an important therapeutic target in melanomaQ28482377
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Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancerQ33420388
TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilizationQ33668662
Metabolic genes in cancer: their roles in tumor progression and clinical implicationsQ33772469
Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysisQ33946905
Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapyQ33997798
Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formationQ34043101
Therapy for metastatic melanoma: the past, present, and future.Q34183225
Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanomaQ34221697
In vitro assessment of 2-fluoro-2-deoxy-D-glucose, L-methionine and thymidine as agents to monitor the early response of a human adenocarcinoma cell line to radiotherapy.Q34363872
Identification of genital tract markers in the human seminal plasma using an integrative genomics approach.Q34424875
Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancerQ34430373
The molecular determinants of de novo nucleotide biosynthesis in cancer cellsQ34939794
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effectQ35605096
Minimization of thermodynamic costs in cancer cell invasionQ36583159
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.Q36793719
Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cellsQ37071513
Role of PET in the initial staging of cutaneous malignant melanoma: systematic reviewQ37326157
Tumor suppressors and cell metabolism: a recipe for cancer growthQ37390879
Metabolic approaches to treatment of melanoma.Q37622612
Lactate: a metabolic key player in cancerQ37956296
Update on the current state of melanoma incidenceQ38026612
How does cancer cell metabolism affect tumor migration and invasion?Q38153177
Molecular pathways: resistance to kinase inhibitors and implications for therapeutic strategiesQ38208748
Systemic treatment for BRAF-mutant melanoma: where do we go next?Q38235584
No longer an untreatable disease: how targeted and immunotherapies have changed the management of melanoma patientsQ38245356
Anaplastic nephroblastomas express transketolase-like enzyme 1.Q38423205
Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?Q38973075
TFDP3 was expressed in coordination with E2F1 to inhibit E2F1-mediated apoptosis in prostate cancerQ39035923
The Ludwig institute for cancer research Melbourne melanoma cell line panelQ39175905
Importance of glycolysis and oxidative phosphorylation in advanced melanomaQ39264242
EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignanciesQ39524428
Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancerQ39686388
Silencing of TKTL1 by siRNA inhibits proliferation of human gastric cancer cells in vitro and in vivoQ39732592
Cancer/testis antigens can be immunological targets in clonogenic CD133+ melanoma cells.Q39883131
Is transketolase like 1 a target for the treatment of differentiated thyroid carcinoma? A study on thyroid cancer cell linesQ39937372
Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK.Q39957913
Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cellsQ40167027
Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycleQ40800971
The role of glucose metabolism and glucose-associated signalling in cancer.Q42174809
TKTL-1 expression in lung cancerQ43658651
Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cellsQ45397670
Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.Q46759205
Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcomeQ48661799
Enhanced TKTL1 expression in malignant tumors of the ocular adnexa predicts clinical outcome.Q50940011
Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases.Q53100877
Cancer testis antigen, ropporin, is a potential target for multiple myeloma immunotherapy.Q53242145
Is transketolase-like protein, TKTL1, transketolase?Q54320672
Metabolic dysregulation in melanoma: cause or consequence?Q54361978
MelanomaQ56428909
2-Deoxy-D-[1-3H]glucose uptake by MCF7 and T47D breast tumour cells under conditions of active proliferation and serum deprivationQ74797260
Effects of thiamine deficiency and of oxythiamine on rat tissue transketolaseQ76455047
Transketolase protein TKTL1 overexpression: A potential biomarker and therapeutic target in breast cancerQ79889033
Tumor antigen expression in melanoma varies according to antigen and stageQ82506715
Cancer-testis antigen expression in primary cutaneous melanoma has independent prognostic value comparable to that of Breslow thickness, ulceration and mitotic rateQ82655417
Limited SP17 expression within tumors diminishes its therapeutic potentialQ85395151
P407language of work or nameEnglishQ1860
P304page(s)134
P577publication date2016-02-22
P1433published inBMC CancerQ326300
P1476titleTransketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells
P478volume16

Reverse relations

cites work (P2860)
Q36265702A first immunohistochemistry study of transketolase and transketolase-like 1 expression in canine hyperplastic and neoplastic mammary lesions.
Q92596041APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression
Q42650181Cancer Immune Equilibrium and Schizophrenia Have Similar Interferon-γ, Tumor Necrosis Factor-α, and Interleukin Expression: A Tumor Model of Schizophrenia
Q39251886EDIM-TKTL1/Apo10 Blood Test: An Innate Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer
Q41388484Evaluation of TKTL1 as a biomarker in serum of prostate cancer patients
Q59350205Evaluation of the Glypican 3 promoter for transcriptional targeting of hepatocellular carcinoma
Q40163628Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor.
Q46166592Promoter hypomethylation of NY-ESO-1, association with clinicopathological features and PD-L1 expression in non-small cell lung cancer
Q61447992The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases

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