Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin.

scientific article

Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NEUONC/NOW174
P932PMC publication ID5464255
P698PubMed publication ID27571886

P50authorMijin YunQ61151102
Jae-Ho CheongQ63644867
Yong-Min HuhQ63978764
Seok-gu KangQ42788516
P2093author name stringJi-Hyun Lee
Junseong Park
Eui Hyun Kim
Jong Hee Chang
Pilnam Kim
Sun Ho Kim
Jeong Yong Jeon
Junjeong Choi
Kyung-Sup Kim
Jin-Kyoung Shim
Ilkyoo Koh
Yoonjee Oh
P2860cites workQuantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharideQ42794498
Differential responses of tumors and normal brain to the combined treatment of 2-DG and radiation in glioablastomaQ43222513
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2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitroQ46630183
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The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesisQ70622105
The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cellsQ95804869
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseQ27860541
Glycolysis inhibition for anticancer treatmentQ28256222
Why do cancers have high aerobic glycolysis?Q28290710
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trialQ29547224
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Glioma expansion in collagen I matrices: analyzing collagen concentration-dependent growth and motility patterns.Q30476738
Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation.Q33877459
Molecular targeting of glioblastoma: Drug discovery and therapiesQ33911283
Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment.Q34007740
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.Q34182185
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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial functionQ35223050
Metabolic state of glioma stem cells and nontumorigenic cellsQ35229102
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effectQ35605096
Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer modelsQ35613319
Metformin: an emerging new therapeutic option for targeting cancer stem cells and metastasisQ36026661
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cellsQ36213711
Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt.Q36604614
Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK.Q36861418
HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion.Q37015151
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Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.Q37205539
Glioma stem cells: turpis omen in nomen? (The evil in the name?).Q38202702
The role of cancer stem cells in glioblastomaQ38272729
Potential use of glioblastoma tumorsphere: clinical credentialing.Q38335033
Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions.Q39176844
Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesisQ40371829
P433issue2
P921main subjectmetforminQ19484
glioblastomaQ282142
P304page(s)197-207
P577publication date2017-02-01
P1433published inNeuro-OncologyQ15724471
P1476titleInhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin
P478volume19

Reverse relations

cites work (P2860)
Q924420292-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
Q58573420Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma
Q89960671Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma
Q90580382Glioblastoma Cellular Origin and the Firework Pattern of Cancer Genesis from the Subventricular Zone
Q30353578Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A).
Q58728819Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability
Q92733028Metformin as Potential Therapy for High-Grade Glioma
Q58698115Metformin as a Therapeutic Target in Endometrial Cancers
Q64236894Mitochondria-centric bioenergetic characteristics in cancer stem-like cells
Q57072227Phenformin and metformin inhibit growth and migration of LN229 glioma cells in vitro and in vivo
Q47222664Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheres
Q47115276Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma
Q64098059Repurposed Biguanide Drugs in Glioblastoma Exert Antiproliferative Effects via the Inhibition of Intracellular Chloride Channel 1 Activity
Q64244912Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR)

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