B cell antigen presentation is sufficient to drive neuroinflammation in an animal model of multiple sclerosis

scientific article published on 20 April 2015

B cell antigen presentation is sufficient to drive neuroinflammation in an animal model of multiple sclerosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.1402236
P932PMC publication ID4433779
P698PubMed publication ID25895531

P50authorChristopher LiningtonQ41652456
Pandelakis A. KoniQ42588019
Chelsea R Parker HarpQ49336637
Stephen T FerrisQ57132789
P2093author name stringGregory F Wu
John H Russell
Michiko Shimoda
Julia Sim
Angela S Archambault
Robert J Mikesell
P2860cites workOligoclonal IgG band patterns in inflammatory demyelinating human and mouse diseasesQ81594596
B-cell depletion with rituximab in relapsing-remitting multiple sclerosisQ28268626
CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunityQ28589339
Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosisQ33702321
Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluidQ33745475
Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiologyQ34048094
Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis.Q34052870
The role of antigen presenting cells in multiple sclerosisQ34268029
Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity.Q34645411
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseasesQ34658996
Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progressionQ34831296
Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation.Q35009513
Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in miceQ35009518
Anti-CD20 B-cell depletion enhances monocyte reactivity in neuroimmunological disordersQ35544312
Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patientsQ35585366
Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate.Q35769109
Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoproteinQ35891689
B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cellsQ35946128
B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunityQ36034499
Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporterQ36117107
Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunityQ36171818
Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammationQ36174679
Multiple sclerosis--the plaque and its pathogenesisQ36410882
Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain.Q36506367
Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesisQ37031308
Antigen specificity of clonally expanded and receptor edited cerebrospinal fluid B cells from patients with relapsing remitting MSQ37258223
Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells.Q37273211
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodiesQ37397820
The role of antibodies in multiple sclerosisQ37769908
The immunopathophysiology of multiple sclerosisQ37857982
Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responsesQ39138822
APCs present A beta(k)-derived peptides that are autoantigenic to type B T cells.Q40656630
B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic miceQ41028078
Atacicept in multiple sclerosis (ATAMS): a randomised, placebo-controlled, double-blind, phase 2 trialQ42647640
Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 miceQ44484576
Experimental autoimmune encephalomyelitis repressed by microglial paralysis.Q45235066
Active induction of experimental allergic encephalomyelitisQ48175463
The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the folliclesQ48914128
Defining antigen-dependent stages of T cell migration from the blood to the central nervous system parenchymaQ48971811
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.Q50515193
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
Role of MHC class II on memory B cells in post-germinal center B cell homeostasis and memory response.Q51985051
Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.Q53846430
De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis.Q53974447
Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?Q57041523
Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T CellsQ58621017
Antigen-specific interaction between T and B cellsQ59063745
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesionsQ59070288
Evidence for pathogenic heterogeneity in multiple sclerosisQ61709616
A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune diseaseQ68834759
Critical role of antigen-specific antibody in experimental autoimmune encephalomyelitis induced by recombinant myelin oligodendrocyte glycoproteinQ74456215
Experimental autoimmune encephalomyelitis (EAE)Q81130780
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectmultiple sclerosisQ8277
neuronitisQ17157137
P304page(s)5077-5084
P577publication date2015-04-20
P1433published inJournal of ImmunologyQ3521441
P1476titleB cell antigen presentation is sufficient to drive neuroinflammation in an animal model of multiple sclerosis
P478volume194

Reverse relations

cites work (P2860)
Q40530656Activated GL7+ B cells are maintained within the inflamed CNS in the absence of follicle formation during viral encephalomyelitis.
Q39594953Amelioration of EAE by a cryptic epitope of myelin oligodendrocyte glycoprotein.
Q58560818Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity
Q36742838Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease.
Q30248983Autoimmunity in 2015.
Q92249491B Cell-Mediated Antigen Presentation through MHC Class II Is Dispensable for Atherosclerosis Progression
Q26770664B Cells Are Multifunctional Players in Multiple Sclerosis Pathogenesis: Insights from Therapeutic Interventions
Q95840980B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers
Q55512364B cells are capable of independently eliciting rapid reactivation of encephalitogenic CD4 T cells in a murine model of multiple sclerosis.
Q91236273B cells in autoimmune and neurodegenerative central nervous system diseases
Q36788638CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis
Q92884441Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients
Q64279716Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis
Q57810320Emerging Role of Follicular T Helper Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Q39509470Increased ex vivo antigen presentation profile of B cells in multiple sclerosis
Q26779416Infection as an Environmental Trigger of Multiple Sclerosis Disease Exacerbation
Q38684427Influenza infection triggers disease in a genetic model of experimental autoimmune encephalomyelitis
Q59126360Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus
Q63363253Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE
Q39188128Monoclonal antibodies in the treatment of multiple sclerosis: emergence of B-cell-targeted therapies
Q49315731Murine splenic B cells express corticotropin-releasing hormone receptor 2 that affect their viability during a stress response
Q33645795Myelin Oligodendrocyte Glycoprotein: Deciphering a Target in Inflammatory Demyelinating Diseases.
Q37014400Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen.
Q90471432Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein
Q38665518Ocrelizumab: a B-cell depleting therapy for multiple sclerosis
Q26743398Positive and negative functions of B lymphocytes in tumors
Q52657141Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation.
Q64082934The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to imaging
Q96171695Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica

Search more.