Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain.

scientific article published on 14 June 2006

Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00109-006-0065-1
P698PubMed publication ID16773356

P50authorMelanie GreterQ84883331
Burkhard BecherQ48129628
P2093author name stringIngo Bechmann
P2860cites workIL-23 drives a pathogenic T cell population that induces autoimmune inflammationQ29547525
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Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.Q49014751
Initiation of immune responses in brain is promoted by local dendritic cells.Q50796487
Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence.Q52028997
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IFN-gamma-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cellsQ56908628
TLR signaling tailors innate immune responses in human microglia and astrocytesQ57041985
Naive T lymphocytes traffic to inflamed central nervous system, but require antigen recognition for activationQ57042465
Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted miceQ57042734
Local enhancement of major histocompatibility complex (MHC) class I and II expression and cell infiltration in experimental allergic encephalomyelitis around axotomized motor neuronsQ57352018
Astrocytes present myelin basic protein to encephalitogenic T-cell linesQ59059821
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Investigation on the expression of major histocompatibility complex class II and cytokines and detection of HIV-1 DNA within brains of asymptomatic and symptomatic HIV-1-positive patientsQ71345946
Characterization and distribution of phagocytic macrophages in multiple sclerosis plaquesQ72091992
HLA class II molecules (HLA-DR, -DP, -DQ) on cells in the human CNS studied in situ and in vitroQ72462837
Blood monocytes and spleen macrophages differentiate into microglia-like cells on monolayers of astrocytes: membrane currentsQ72630579
Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cellsQ72896286
Astrocytes and central nervous system endothelial cells do not express B7-1 (CD80) or B7-2 (CD86) immunoreactivity during experimental autoimmune encephalomyelitisQ73056300
IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxideQ73160690
Studies on the problem of corneal homograftsQ73219232
CD40 engagement stimulates IL-12 p70 production by human microglial cells: basis for Th1 polarization in the CNSQ73336410
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Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 miceQ73966732
Immunopathogenesis of multiple sclerosis: MBP and beyondQ74307292
Inflammation and atrophy in multiple sclerosis: MRI associations with disease courseQ74458832
Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytesQ74515347
Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blastsQ74597390
Myelin basic protein in CSF as indicator of disease activity in multiple sclerosisQ77377216
IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelinationQ78626045
Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitisQ81129297
EAE in beta-2 microglobulin-deficient mice: axonal damage is not dependent on MHC-I restricted immune responsesQ81662114
CD95-CD95L: can the brain learn from the immune system?Q41733641
Antigen presentation by human fetal astrocytes with the cooperative effect of microglia or the microglial-derived cytokine IL-1.Q42490295
Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitisQ42753284
Requirement for Θ-Bearing Cells in Lymphocytic Choriomeningitis Virus-induced Central Nervous System DiseaseQ44188481
Experimental autoimmune encephalomyelitis repressed by microglial paralysis.Q45235066
Functional activation of myelin-specific T cells by virus-induced molecular mimicryQ45731233
Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment.Q45881740
Vasoactive intestinal polypeptide inhibits the expression of the MHC class II antigens on astrocytesQ46426276
Mature microglia resemble immature antigen-presenting cellsQ46471783
Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammationQ46531302
Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cellsQ46681487
Targeting of adoptively transferred experimental allergic encephalitis lesion at the sites of wallerian degeneration.Q46708317
In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytologyQ47288465
Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo.Q47757443
Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in rats.Q47763732
Astrocytic factors deactivate antigen presenting cells that invade the central nervous system.Q47820908
Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulationQ48099875
FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrierQ48166557
Lymphocyte targeting of the brain in adoptive transfer cryolesion-EAE.Q48188763
Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cellsQ48215877
Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparationsQ48250691
Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis.Q48286199
A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentationQ48349929
Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new viewQ48400195
Interactions between hemopoietically derived TNF and central nervous system-resident glial chemokines underlie initiation of autoimmune inflammation in the brainQ48430048
Transfer of central nervous system autoantigens and presentation in secondary lymphoid organsQ48451211
Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditionsQ48476538
Bacillus Calmette-Guérin sequestered in the brain parenchyma escapes immune recognitionQ48495713
Mouse resident microglia: isolation and characterization of immunoregulatory properties with naïve CD4+ and CD8+ T-cellsQ48501197
Ia expression and antigen presentation by glia: strain and cell type-specific differences among rat astrocytes and microgliaQ48587633
Role of cervical lymph nodes in autoimmune encephalomyelitis in the Lewis rat.Q48642423
How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodesQ48744849
Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microgliaQ48926167
Turnover of rat brain perivascular cellsQ48946702
P433issue7
P304page(s)532-543
P577publication date2006-06-14
P1433published inJournal of Molecular MedicineQ6295593
P1476titleAntigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain
P478volume84

Reverse relations

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