Honokiol induces cell cycle arrest and apoptosis via p53 activation in H4 human neuroglioma cells

scientific article published on 15 May 2015

Honokiol induces cell cycle arrest and apoptosis via p53 activation in H4 human neuroglioma cells is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID4509200
P698PubMed publication ID26221255

P2093author name stringXing-Dong Zhang
Hai-Yan Liu
Xin-Jie Bao
Yun-Bao Guo
Song-Bai Xu
P2860cites workHonokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivoQ28180577
Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species productionQ28185379
Mitotic kinases as regulators of cell division and its checkpointsQ28202545
Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell functionQ28246944
Therapeutic applications of compounds in the Magnolia familyQ28304238
p53-dependent apoptosis in melanoma cells after treatment with camptothecinQ28371768
Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cellsQ28478749
The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.Q34197362
Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylationQ34734168
Histone acetyltransferase inhibitor II induces apoptosis in glioma cell lines via the p53 signaling pathwayQ35063895
Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell deathQ35068689
Evaluation of anti-HIF and anti-angiogenic properties of honokiol for the treatment of ocular neovascular diseases.Q35448249
Jaridonin-induced G2/M phase arrest in human esophageal cancer cells is caused by reactive oxygen species-dependent Cdc2-tyr15 phosphorylation via ATM-Chk1/2-Cdc25C pathwayQ36486960
Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO.Q36496451
The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathwaysQ37112443
Cell cycle arrest and apoptotic induction in LNCaP cells by MCS-C2, novel cyclin-dependent kinase inhibitor, through p53/p21WAF1/CIP1 pathwayQ38510413
CR389, a benzoimidazolyl pyridinone analog, induces cell cycle arrest and apoptosis via p53 activation in human ovarian cancer PA-1 cellsQ38914442
Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in SGC-7901 cells and inhibits tumor growth in vivoQ38917846
Knockdown of CDC2 expression inhibits proliferation, enhances apoptosis, and increases chemosensitivity to temozolomide in glioblastoma cellsQ38936969
The mechanism of honokiol-induced intracellular Ca(2+) rises and apoptosis in human glioblastoma cellsQ38967800
Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cellsQ38987655
Honokiol inhibits U87MG human glioblastoma cell invasion through endothelial cells by regulating membrane permeability and the epithelial-mesenchymal transitionQ39061712
In vitro growth inhibition of human cancer cells by novel honokiol analogsQ39358757
Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathwayQ39460930
Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stressQ39780862
Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cellsQ39896830
Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines.Q40127963
Honokiol inhibits the progression of collagen-induced arthritis by reducing levels of pro-inflammatory cytokines and matrix metalloproteinases and blocking oxidative tissue damageQ42940156
Oligosaccharide G19 inhibits U-87 MG human glioma cells growth in vitro and in vivo by targeting epidermal growth factor (EGF) and activating p53/p21 signalingQ46897628
Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed miceQ47894985
p53-dependent pathways of apoptosisQ77099494
P433issue5
P304page(s)7168-7175
P577publication date2015-05-15
P1433published inInternational Journal of Clinical and Experimental MedicineQ6051338
P1476titleHonokiol induces cell cycle arrest and apoptosis via p53 activation in H4 human neuroglioma cells
P478volume8

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cites work (P2860)
Q33919087Honokiol inhibits c-Met-HO-1 tumor-promoting pathway and its cross-talk with calcineurin inhibitor-mediated renal cancer growth
Q47962641Honokiol protects skin cells against inflammation, collagenolysis, apoptosis, and senescence caused by cigarette smoke damage
Q64980315The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling.

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