CpG island methylation in colorectal adenomas

scientific article published on September 2001

CpG island methylation in colorectal adenomas is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0002-9440(10)61789-0
P932PMC publication ID1850474
P698PubMed publication ID11549606

P2093author name stringHamilton SR
Rashid A
Issa JP
Shen L
Morris JS
P2860cites workMethylation-specific PCR: a novel PCR assay for methylation status of CpG islandsQ24631957
CpG island methylator phenotype in colorectal cancerQ24672170
Lessons from hereditary colorectal cancerQ28131788
CpG-rich islands and the function of DNA methylationQ28131800
The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesisQ28138414
Mutations in the p53 gene occur in diverse human tumour typesQ28249770
APC mutations occur early during colorectal tumorigenesisQ28274764
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinomaQ29615026
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancerQ29615066
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell linesQ29620526
Cancer genetics: tumor suppressor meets oncogene.Q33533777
TGF-beta receptors and DNA repair genes, coupled targets in a pathway of human colon carcinogenesisQ33828926
COBRA: a sensitive and quantitative DNA methylation assayQ34630070
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotypeQ34975498
Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominanceQ35188735
Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomasQ35355359
Microdissection and polymerase chain reaction amplification of genomic DNA from histological tissue sectionsQ35764415
Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG islandQ38303631
The primary function of a redundant Sp1 binding site in the mouse aprt gene promoter is to block epigenetic gene inactivationQ38331684
Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumorsQ40927952
DNA methylation errors and cancer.Q41000721
X chromosome imprinting and inactivation in the early mammalian embryoQ41196156
Alterations in DNA methylation: a fundamental aspect of neoplasiaQ41617101
Microsatellite instability: the mutator that mutates the other mutatorQ44602861
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancerQ45345220
Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1Q50893078
Ki-ras mutations in adenomas: a characteristic of cancer-bearing colorectal mucosaQ52892421
Alterations in DNA Methylation: A Fundamental Aspect of NeoplasiaQ56418625
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesisQ57240066
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasiaQ57240085
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancersQ71167724
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancersQ71729088
Genomic instability occurs in colorectal carcinomas but not in adenomasQ72649470
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colonQ72781919
Microsatellite instability in colorectal adenomasQ73309470
Association between CpG island methylation and microsatellite instability in colorectal cancerQ73622839
Association of K-ras mutations with p16 methylation in human colon cancerQ77374977
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectCpG islandQ1138360
P304page(s)1129-1135
P577publication date2001-09-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleCpG island methylation in colorectal adenomas
P478volume159

Reverse relations

cites work (P2860)
Q33914431A beta-mixture model for dimensionality reduction, sample classification and analysis
Q39751557A five-gene signature as a potential predictor of metastasis and survival in colorectal cancer
Q35584153A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy
Q39560142AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene
Q54719199Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia.
Q30494652Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model
Q35605612Aberrant crypt foci as microscopic precursors of colorectal cancer
Q37214832Aberrant crypt foci as precursors in colorectal cancer progression
Q38166581Aberrant crypt foci: the case for inclusion as a biomarker for colon cancer
Q35075702Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder
Q37347838Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors
Q37683456Age-related epigenetic drift in the pathogenesis of MDS and AML.
Q54690884Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsatellite instability within the same tumor using a single tumor gland from colorectal carcinomas.
Q28757763Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas
Q89843964Association Between Molecular Subtypes of Colorectal Tumors and Patient Survival, Based on Pooled Analysis of 7 International Studies
Q36619262Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy.
Q46365032BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer
Q35369905BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma
Q60046390Biomarkers in colorectal cancer: Current clinical utility and future perspectives
Q40007314Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development.
Q36172680CIMP and colon cancer gets more complicated
Q39258008Case-control study of candidate gene methylation and adenomatous polyp formation
Q36699559Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
Q54551065Clinicopathologic and molecular features of sporadic microsatellite- and chromosomal-stable colorectal cancers.
Q48500704Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratified for Helicobacter pylori infection
Q35747320Concordant CpG island methylation in hyperplastic polyposis.
Q54627726CpG island methylation as an early event during adenoma progression in carcinogenesis of sporadic colorectal cancer.
Q35748049CpG island methylation in aberrant crypt foci of the colorectum
Q36854134CpG island methylation in familial colorectal cancer patients not fulfilling the Amsterdam criteria
Q83365535CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer
Q35807863CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations
Q61865606DNA methylation changes in ex-adenoma carcinoma of the large intestine
Q83767772DNA methylation defects in sporadic and hereditary colorectal cancer
Q37687919DNA methylation markers in colorectal cancer
Q35785652DNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polyps
Q37776026DNA methylation profiling in cancer
Q92405306Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk
Q35646086Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report
Q28087759Emerging technologies for studying DNA methylation for the molecular diagnosis of cancer
Q35118511Epidemiologic considerations to assess altered DNA methylation from environmental exposures in cancer.
Q84699545Epigenetic Biomarkers
Q33235330Epigenetic alterations in RASSF1A in human aberrant crypt foci
Q44429799Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas.
Q44938471Epigenetic events and protection from colon cancer in New Zealand.
Q35782660Epigenetic modulation to enable antigen-specific T-cell therapy of colorectal cancer
Q36529734Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma
Q36081553Epigenetics and colorectal cancer
Q45362780Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study
Q39182132Expression of Type 2 Orexin Receptor in Human Endometrium and Its Epigenetic Silencing in Endometrial Cancer
Q34416852Field cancerization in the colon: a role for aberrant DNA methylation?
Q35542190Folate, DNA methylation and colo-rectal cancer
Q35791305Frequent CpG island methylation in serrated adenomas of the colorectum
Q35118470Genetic and Epigenetic Mosaicism in Cancer Precursor Tissues
Q37126768Genetic and epigenetic changes in aberrant crypt foci and serrated polyps
Q57977995Genetics supersedes epigenetics in colon cancer phenotype
Q64119959Genome-wide methylation profiling identified novel differentially hypermethylated biomarker MPPED2 in colorectal cancer
Q33836026Genomic and epigenetic instability in colorectal cancer pathogenesis
Q35029017Hypermethylation pathways to colorectal cancer. Implications for prevention and detection
Q53542026Hypermethylation status of APC inversely correlates with the presence of submucosal invasion in laterally spreading colorectal tumors.
Q58104493Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway
Q47375648INK4a-ARF alterations in Barrett's epithelium, intraepithelial neoplasia and Barrett's adenocarcinoma
Q35594804INK4a-ARF alterations in liver cell adenoma
Q46967606INK4a-ARF alterations in liver cell adenoma
Q35194198Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
Q37582033Identification of novel hypermethylated genes and demethylating effect of vincristine in colorectal cancer
Q42241147Lack of Aberrant Methylation in an Adjacent Area of Left-Sided Colorectal Cancer
Q34225341Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer
Q37620965Methods for genome-wide analysis of DNA methylation in intestinal tumors
Q54720252Methylation in p14(ARF) is frequently observed in colorectal cancer with low-level microsatellite instability.
Q36076356Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis
Q28243755Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders
Q36891683Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer
Q34358286Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer
Q95725436O6-Methyguanine-DNA Methyl Transferase (MGMT) Promoter Methylation in Serum DNA of Iranian Patients with Colorectal Cancer
Q35761211Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa
Q89636437Past, present, and future of genetic research in borderline personality disorder
Q30585819Patterns of DNA methylation in the normal colon vary by anatomical location, gender, and age
Q37733784Prognostic and predictive value of CpG island methylator phenotype in patients with locally advanced nonmetastatic sporadic colorectal cancer.
Q51603737Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers
Q44981691Prolapse-related changes are a confounding factor in misdiagnosis of sessile serrated adenomas in the rectum
Q53364696Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia
Q37245289Promoter methylation in the genesis of gastrointestinal cancer
Q53337445Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer
Q24603535Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas
Q36144242Quantitative Analysis of Cancer-associated Gene Methylation Connected to Risk Factors in Korean Colorectal Cancer Patients
Q53343035Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas
Q26827208Serrated lesions of the colorectum: review and recommendations from an expert panel
Q46530603Serum methylation levels ofTAC1. SEPT9andEYA4as diagnostic markers for early colorectal cancers: a pilot study
Q33770826Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract.
Q92193162The Evolving Biomarker Landscape for Treatment Selection in Metastatic Colorectal Cancer
Q36383337The blues of P(16)INK(4a): aberrant promoter methylation and association with colorectal cancer in the Kashmir valley.
Q36656549The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening
Q38533166The recent progress of the mechanism and regulation of tumor necrosis in colorectal cancer
Q35749254The relationship between hypomethylation and CpG island methylation in colorectal neoplasia
Q35096122The role of the cyclin D1-dependent kinases in ErbB2-mediated breast cancer
Q35711210Zic1 Promoter Hypermethylation in Plasma DNA Is a Potential Biomarker for Gastric Cancer and Intraepithelial Neoplasia
Q36556548p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer.

Search more.