Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma

scientific article published on April 1997

Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P932PMC publication ID1858185
P698PubMed publication ID9094970

P2093author name stringM A Feitelson
L X Duan
P2860cites workTGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreasQ43826975
Regulation of insulin-like growth factor II Gene expression by hepatitis B virus in hepatocellular carcinomaQ43874896
Hepatitis B virus: pathogenesis and prevention of primary cancer of the liverQ44101756
HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactionsQ44489320
Wild-type p53 binds to the TATA-binding protein and represses transcriptionQ24300991
Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivationQ24310197
Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinomaQ24563988
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1Q24564855
Proteasome complex as a potential cellular target of hepatitis B virus X proteinQ24681896
Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinomaQ28241770
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I moleculesQ28248180
Amplification of a gene encoding a p53-associated protein in human sarcomasQ28270924
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationQ28280958
Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinomaQ28287494
p53 mutations in human cancersQ28302973
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κBQ28508403
Polymerase II promoter activation: closed complex formation and ATP-driven start site openingQ28646720
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
An essential role for NF-kappaB in preventing TNF-alpha-induced cell deathQ29614707
p53-dependent apoptosis modulates the cytotoxicity of anticancer agentsQ29615031
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaQ29615437
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa BQ29618194
Suppression of TNF-alpha-induced apoptosis by NF-kappaBQ29618717
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factorQ29619833
Hepatitis B virus HBx protein deregulates cell cycle checkpoint controlsQ33765576
Hepatitis B virus X gene can transactivate heterologous viral sequencesQ33845263
Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in TaiwanQ34054719
Abrogation of p53-induced apoptosis by the hepatitis B virus X geneQ34367126
Hepatocarcinogenicity of the woodchuck hepatitis virusQ34594377
Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.Q34673509
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3Q35101216
Hepatocellular carcinoma: Recent progressQ35227361
Hepatitis B virus infection and primary hepatocellular carcinomaQ35231554
Hepatocellular carcinoma in ground squirrels persistently infected with ground squirrel hepatitis virusQ35612599
Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivationQ35835238
Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascadeQ35850088
Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replicationQ35866048
Chronic hepatitis and hepatocellular carcinoma associated with woodchuck hepatitis virusQ35885615
Hepatocellular carcinoma and dietary aflatoxin in Mozambique and TranskeiQ35992152
Review: hepatitis B virus X-gene product: a promiscuous transcriptional activatorQ36100142
The p53 tumor suppressor protein, a modulator of cell proliferationQ36362434
Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNAQ36488685
Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.Q36508624
Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from a chronically infected liverQ36598907
Woodchuck hepatitis virus X protein is required for viral infection in vivoQ36630766
The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks.Q36642780
Interleukin-2 downregulates hepatitis B virus gene expression in transgenic mice by a posttranscriptional mechanism.Q36655403
p53-mediated cell death: relationship to cell cycle controlQ36675212
Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common hostQ36683401
Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic miceQ36698569
Hepatitis B virus transactivator X protein is not tumorigenic in transgenic miceQ36796019
Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replicationQ36830695
Insulinlike growth factor II expression and oval cell proliferation associated with hepatocarcinogenesis in woodchuck hepatitis virus carriersQ36872573
Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virionsQ36878776
DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic miceQ37326913
Degradation of nuclear oncoproteins by the ubiquitin system in vitroQ37361143
Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeatQ37565289
Frequent amplification of c-myc in ground squirrel liver tumors associated with past or ongoing infection with a hepadnavirusQ37599222
Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNAQ37608976
Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal associationQ37833427
The p53 protein and its interactions with the oncogene products of the small DNA tumor virusesQ37855772
Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis.Q37894884
Putting it on and taking it off: phosphoprotein phosphatase involvement in cell cycle regulationQ38274350
Functional inactivation but not structural mutation of p53 causes liver cancer.Q38300638
Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathwayQ38321449
Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localizationQ38327000
Hepatitis B virus gene products as immunological targets in chronic infectionQ38770452
Hepatitis B virus. The major etiology of hepatocellular carcinomaQ39199064
Prooxidant states and tumor promotionQ39492603
Chronic type B hepatitis and the "healthy" HBsAg carrier stateQ39662797
Apoptosis is induced by N-myc expression in hepatocytes, a frequent event in hepadnavirus oncogenesis, and is blocked by insulin-like growth factor II.Q39873599
Insulin-like growth factor II blocks apoptosis of N-myc2-expressing woodchuck liver epithelial cellsQ39876155
The X protein of hepatitis B virus coactivates potent activation domainsQ40021717
Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase CQ40064034
Induction of cell cycle progression by hepatitis B virus HBx gene expression in quiescent mouse fibroblastsQ40345663
Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesisQ40386904
Oxidative mechanisms in carcinogenesisQ40771862
A comparison of the biological activities of wild-type and mutant p53.Q40831456
Antiviral therapy of chronic hepatitis B: past, present, and futureQ40915924
pX, the HBV-encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent mannerQ41075171
Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours.Q41205751
Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNAQ41206745
X antigen/antibody markers in hepadnavirus infections. Presence and significance of hepadnavirus X gene product(s) in serumQ41225239
X antigen polypeptides in the sera of hepatitis B virus-infected patientsQ41232256
Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX.Q41437081
Transactivation of human hepatitis B virus X protein, HBx, operates through a mechanism distinct from protein kinase C and okadaic acid activation pathwaysQ41487392
Interaction of heat-shock protein 70 with p53 translated in vitro: evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformationQ41532796
Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agentsQ41575832
Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysisQ41675964
In vitro tumorigenicity of hepatitis B virus DNA and HBx proteinQ41705071
Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic miceQ41736950
Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factorsQ41742365
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic miceQ41757834
Identification of human ventricular myosin heavy chain fragments with monoclonal antibody 2F4 in human sera after myocardial necrosisQ41878123
Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinomaQ42027794
Disruption of the function of tumor-suppressor gene p53 by the hepatitis B virus X protein and hepatocarcinogenesisQ42478545
The 17 kDa HBx protein encoded by hepatitis B virus interacts with the activation domains of Oct-1, and functions as a coactivator in the activation and repression of a human U6 promoter.Q42500514
Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: implications of IGF-I receptor gene activation by hepatitis B virus X gene product.Q42519906
Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virusQ42624587
Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucksQ43470081
Expression of insulin-like growth factor II, α-fetoprotein and hepatitis B virus transcripts in human primary liver cancerQ43494203
The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.Q44779333
Hepatocarcinogenesis is the sequel to hepatitis in Z#2 alpha 1-antitrypsin transgenic mice: histopathological and DNA ploidy studiesQ44990068
The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cellsQ45166424
Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinomaQ45279592
Hepatitis B virus X gene expression is activated by X protein but repressed by p53 tumor suppressor gene product in the transient expression systemQ45771119
Effect of hepatocyte proliferation and cellular DNA synthesis on hepatitis B virus replicationQ45771158
Effect of X protein on transactivation of hepatitis B virus promoters and on viral replicationQ45776308
Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor.Q45776760
High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic miceQ45779177
The X protein of hepatitis B virus has a ribo/deoxy ATPase activityQ45781571
Hepatitis B virus X gene product acts as a transactivator in vivo.Q45782366
Expression of insulin-like growth factor II in hepatitis B, cirrhosis and hepatocellular carcinoma: its relationship with hepatitis B virus antigen expressionQ45783000
Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinomas of woodchucksQ45799782
A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated stateQ45840310
Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinomaQ45840313
Feasibility of controlling or eradicating the hepatitis B virusQ45843147
Instability of integrated hepatitis B virus DNA with inverted repeat structure in a transgenic mouseQ45843701
Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China.Q45846130
Monoclonal antibodies raised to purified woodchuck hepatitis virus core antigen particles demonstrate X antigen reactivityQ45849139
Transgenic mice containing hepatitis B virus sequences are more susceptible to carcinogen-induced hepatocarcinogenesisQ45849190
The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonine kinaseQ45850090
X protein of hepatitis B virus resembles a serine protease inhibitorQ45852144
HBx gene of hepatitis B virus induces liver cancer in transgenic miceQ45852802
The interaction of RNA polymerase II with the adenovirus-2 major late promoter is precluded by phosphorylation of the C-terminal domain of subunit IIaQ46025547
The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigenQ46840212
Oncogene-induced liver neoplasia in transgenic mice.Q53515079
Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis.Q53519243
Stalking the start of colon cancer.Q54637593
The insulin-like growth factor I receptor: a key to tumor growth?Q55481189
The hepatitis B virusQ59051957
Pathogenesis of posttransfusion viral hepatitis in children with β-thalassemiaQ63236723
Regulation of the human hsp70 promoter by p53Q64377885
Hepatitis B X-gene expression in hepatocellular carcinomaQ67507097
HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosisQ67693862
Effect of the Bowman-Birk protease inhibitor on the expression of oncogenes in the irradiated rat colonQ67995364
Analysis of insulin-like growth factor II (IGF-II) expression in neoplastic nodules and hepatocellular carcinomas of woodchucks utilizing in situ hybridization and imununocytochemistryQ68260062
Products of the "X" gene in hepatitis B and related virusesQ68957799
The value of hepatitis B x antigen as a prognostic marker in the development of hepatocellular carcinomaQ70498398
DNA repair. Engagement with transcriptionQ70683866
Characteristics of woodchuck hepatitis X-antigen in the livers and sera from infected animalsQ70756305
Hepatoma-derived integrated HBV DNA causes multi-stage transformation in vitroQ71061778
In vivo ubiquitination and proteasome-mediated degradation of p53(1)Q71129152
Slow DNA repair implicated in mutations found in tumorsQ72293083
[Preparation of monoclonal antibody directed against hepatitis B virus X protein and detection of reactive antigen in hepatocellular carcinoma]Q72502872
Transgenic mouse models of hepatocellular carcinomaQ72738468
Presence of Hepatitis B Surface Antigen Before Primary Hepatocellular CarcinomaQ72927130
Distribution of hepatitis B surface and core antigens in human liver cell carcinoma and surrounding nontumorous liverQ72945063
Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinomaQ72966947
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectHepatitis B virusQ6844
hepatitis BQ6853
P304page(s)1141-1157
P577publication date1997-04-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleHepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma
P478volume150

Reverse relations

cites work (P2860)
Q37265609A case-control study of the relationship between hepatitis B virus DNA level and risk of hepatocellular carcinoma in Qidong, China
Q38271599A comprehensive molecular interaction map for Hepatitis B virus and drug designing of a novel inhibitor for Hepatitis B X protein
Q26822570AEG-1/MTDH/LYRIC in liver cancer
Q24647547Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression
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Q45325156Expression, purification and characterization of hepatitis B virus X protein BH3-like motif-linker-Bcl-xL fusion protein for structural studies
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Q37311716HBx Gene Mutations in Hepatitis B Virus and Hepatocellular Carcinoma
Q38829387HBx interacted with Smad4 to deprive activin a growth inhibition function in hepatocyte HL7702 on CRM1 manner
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Q36389497Hepatitis B virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in Caenorhabditis elegans
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Q45387956Hepatitis B virus X protein upregulates expression of SMYD3 and C-MYC in HepG2 cells
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Q37388018Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease
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Q36237549TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.
Q89497633Targeting PIN1 as a Therapeutic Approach for Hepatocellular Carcinoma
Q24681487The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas
Q39740159The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression
Q33552832Transformation of human liver L-O2 cells mediated by stable HBx transfection
Q28073477Understanding the role of PIN1 in hepatocellular carcinoma
Q34771678Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis
Q36814387Viral genotypes and associated risk factors of hepatocellular carcinoma in India
Q30366407Virtual screening of natural inhibitors to the predicted HBx protein structure of Hepatitis B Virus using molecular docking for identification of potential lead molecules for liver cancer
Q36291789p53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation

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