Carboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in hepatocellular carcinoma development

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Carboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in hepatocellular carcinoma development is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...622888Y
P356DOI10.1371/JOURNAL.PONE.0022888
P932PMC publication ID3150371
P698PubMed publication ID21829663
P5875ResearchGate publication ID51559976

P50authorYangchao ChenQ60312749
Ka Fai ToQ99551275
Nathalie WongQ114442539
Wing-Kit YipQ117282527
Ranxu ZhuQ117282528
Vincent Wai-Sun WongQ38135899
Henry Lik-Yuen ChanQ38135921
Joseph Jao-Yiu SungQ38135970
Paul Bo-San LaiQ43682730
Alfred S. ChengQ44364620
P2093author name stringJun Yu
Daisy Pui-Fong Tsang
Enders Kai-On Ng
Jonathan Gabriel Sung
Raymond Wai-Ming Lung
Suki Shuk-Kei Lau
P2860cites workMicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3BQ24564757
MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1)Q24617676
MicroRNA expression, survival, and response to interferon in liver cancerQ24647241
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.Q24651016
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer modelQ24655262
Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alphaQ27485874
Hepatitis C Virus Proteins Modulate MicroRNA Expression and Chemosensitivity in Malignant HepatocytesQ27490901
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteinsQ27863380
Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinomaQ28118779
Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesisQ28256626
MiRNA-26b regulates the expression of cyclooxygenase-2 in desferrioxamine-treated CNE cellsQ28271329
MYC stimulates EZH2 expression by repression of its negative regulator miR-26aQ28291303
Human embryonic stem cells and metastatic colorectal cancer cells shared the common endogenous human microRNA-26bQ28292904
MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2Q28302211
Characterisation of hepatitis B virus X protein mutants in tumour and non-tumour liver cells using laser capture microdissection.Q30967003
MicroRNA-193b represses cell proliferation and regulates cyclin D1 in melanomaQ33816470
Liver-enriched transcription factors regulate microRNA-122 that targets CUTL1 during liver development.Q34138074
Negative regulation of the tumor suppressor p53 gene by microRNAs.Q34142778
The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damageQ34438821
Hepatitis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cellsQ34666783
Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.Q34673509
Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathwaysQ34721581
Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival.Q34742406
MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1.Q34786558
Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblastsQ34983424
Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma.Q35596851
Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinomaQ35764338
Hepatocellular carcinoma and hepatitis B virusQ36467980
High viral load and hepatitis B virus subgenotype ce are associated with increased risk of hepatocellular carcinomaQ45397941
The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription.Q45409349
Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.Q45747173
HBx gene of hepatitis B virus induces liver cancer in transgenic miceQ45852802
Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin.Q53544194
miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.Q54780999
RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinomaQ79764501
MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cellsQ84590881
Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus.Q36498203
The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factorsQ36684890
MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytesQ37067623
Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6Q37142068
MicroRNAs and cancer epigenetics.Q37179121
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcomaQ37311506
Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasisQ37368106
Deregulated direct targets of the hepatitis B virus (HBV) protein, HBx, identified through chromatin immunoprecipitation and expression microarray profilingQ37372165
Modulation of LMP2A expression by a newly identified Epstein-Barr virus-encoded microRNA miR-BART22Q37399274
Epigenetic regulation of signaling pathways in cancer: role of the histone methyltransferase EZH2.Q37822876
Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters.Q38316206
EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis.Q39554903
Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3.Q39706915
miR-193b is an epigenetically regulated putative tumor suppressor in prostate cancer.Q39752124
Hepatitis B viral X protein alters the biological features and expressions of DNA repair enzymes in LO2 cellsQ39766005
Downregulation of miR-193b contributes to enhance urokinase-type plasminogen activator (uPA) expression and tumor progression and invasion in human breast cancerQ39809297
Subcellular mislocalization of mutant hepatitis B X proteins contributes to modulation of STAT/SOCS signaling in hepatocellular carcinoma.Q39868194
Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinomaQ39890346
MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicityQ39893180
COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesisQ39951374
Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinomaQ39958103
COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosisQ39965123
X protein of hepatitis B virus functions as a transcriptional corepressor on the human telomerase promoterQ40121980
Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X proteinQ40149729
Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2.Q40541428
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathwayQ40839488
A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2-deficient miceQ40909623
MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling.Q41412869
Loss of mir-146a function in hormone-refractory prostate cancerQ42055882
Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues.Q42663074
Correlation of tissue-specific methylation with gene inactivity in hepatitis B virus transgenic miceQ43984536
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinomaQ44956160
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
hepatocellular carcinomaQ1148337
P304page(s)e22888
P577publication date2011-08-04
P1433published inPLOS OneQ564954
P1476titleCarboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in hepatocellular carcinoma development
P478volume6