X protein of hepatitis B virus functions as a transcriptional corepressor on the human telomerase promoter

scientific article published on August 2007

X protein of hepatitis B virus functions as a transcriptional corepressor on the human telomerase promoter is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HEP.21675
P698PubMed publication ID17559154
P5875ResearchGate publication ID6278052

P2093author name stringFull-Young Chang
Keng-Hsin Lan
Shou-Dong Lee
Chung-Pin Li
Yee Chao
Sang-Hue Yen
Jiun-Ming Su
Wei-Ping Lee
Xiang-Me Lai
P2860cites workHuman RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivationQ24310197
MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and terminationQ24316955
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeatsQ24339608
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applicationsQ24561689
Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alphaQ27485874
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ)Q28278072
The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1Q28278426
Characterization of the human endothelial nitric-oxide synthase promoterQ28294946
Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoterQ28304787
The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosisQ28355178
Conservation of the human telomere sequence (TTAGGG)n among vertebratesQ28776595
Structure and function of telomeresQ29615759
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomesQ29617061
Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cellsQ31009822
Hepatitis B virus X protein interferes with cellular DNA repair.Q33781959
Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 geneQ33833014
Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx proteinQ33834716
Management of hepatitis B: 2000--summary of a workshopQ34263265
Hepatitis B virus X protein: a multifunctional viral regulatorQ34423640
The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damageQ34438821
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3Q35101216
Telomerase activity in human ovarian carcinomaQ35142569
A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoterQ36551440
HBx protein of hepatitis B virus activates Jak1-STAT signalingQ38333320
Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signalQ38355045
Structure and function of telomeresQ38763424
Hepatitis B virus pX targets TFIIB in transcription coactivationQ39574625
Upregulation of human telomerase reverse transcriptase mRNA expression by in vitro transfection of hepatitis B virus X gene into human hepatocarcinoma and cholangiocarcinoma cellsQ40359921
Telomeres: beginning to understand the end.Q40383344
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potentialQ40558090
Telomerase activity in human hepatocellular carcinoma: parallel correlation with human telomerase reverse transcriptase (hTERT) mRNA isoform expression but not with cell cycle modulators or c-Myc expressionQ40739034
Two consecutive zinc fingers in Sp1 and in MAZ are essential for interactions with cis-elementsQ40800674
The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascadeQ40816601
The transcription factors SP1 and MAZ regulate expression of the parathyroid hormone/parathyroid hormone-related peptide receptor geneQ40837613
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathwayQ40839488
Phenylethanolamine N-methyltransferase gene expression. Sp1 and MAZ potential for tissue-specific expressionQ40966182
X-gene product of hepatitis B virus induces apoptosis in liver cellsQ41067693
Identification of naturally occurring dominant negative mutants of thyroid hormone alpha 1 and beta 1 receptors in a human hepatocellular carcinoma cell lineQ41164809
Transcriptional repression of p21(waf1) promoter by hepatitis B virus X protein via a p53-independent pathwayQ42825156
Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells.Q45504517
The absence of up-regulation of telomerase activity during regeneration after partial hepatectomy in hepatitis B virus X gene transgenic miceQ45722513
HBx gene of hepatitis B virus induces liver cancer in transgenic miceQ45852802
Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sectionsQ47975586
Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesisQ48168036
HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice.Q53370903
In situdetection of telomerase enzymatic activity in human hepatocellular carcinogenesisQ57782852
Correlating telomerase activity levels with human neuroblastoma outcomesQ71803058
Telomerase activity and telomere length in hepatocellular carcinoma and chronic liver diseaseQ73047915
Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesisQ73136433
Reduction of telomeric repeats as a possible predictor for development of hepatocellular carcinoma: convenient evaluation by slot-blot analysisQ78045240
Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatomaQ80299557
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectHepatitis B virusQ6844
P304page(s)402-413
P577publication date2007-08-01
P1433published inHepatologyQ15724398
P1476titleX protein of hepatitis B virus functions as a transcriptional corepressor on the human telomerase promoter
P478volume46

Reverse relations

cites work (P2860)
Q37688204Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma
Q33988586Carboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in hepatocellular carcinoma development
Q34982993Cause-specific telomere factors deregulation in hepatocellular carcinoma
Q64057610Compound L Inhibits HBV-Related HCC through HBx-SHH Pathway Axis Inactivation
Q64911550Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling.
Q37727964Gene expression profiles of human liver cells mediated by hepatitis B virus X protein
Q45387956Hepatitis B virus X protein upregulates expression of SMYD3 and C-MYC in HepG2 cells
Q39747026Hepatitis B virus X protein upregulates transcriptional activation of human telomerase reverse transcriptase
Q27024874Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma
Q38302100How did hepatitis B virus effect the host genome in the last decade?
Q38000019Infection, mutation, and cancer evolution
Q28592770Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes
Q51734658Significant SNPs Related to Telomere Length and Hepatocellular Carcinoma Risk in Chronic Hepatitis B Carriers
Q38056849Tackling hepatitis B virus-associated hepatocellular carcinoma--the future is now.
Q26739925Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene

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