| scholarly article | Q13442814 |
| P50 | author | Mary B Goldring | Q52565525 |
| P2093 | author name string | Kenneth B Marcu | |
| P2860 | cites work | Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions | Q83452293 |
| mRNA expression profiling reveals conserved and non-conserved miR-140 targets | Q84482822 | ||
| Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro | Q84627089 | ||
| Human primary articular chondrocytes, chondroblasts-like cells, and dedifferentiated chondrocytes: differences in gene, microRNA, and protein expression and phenotype | Q84962490 | ||
| Epigenetic Networks and miRNAs in Stem Cells and Cancer | Q85015001 | ||
| Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis | Q21195359 | ||
| Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase | Q24293656 | ||
| Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase | Q24318629 | ||
| miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice | Q24595073 | ||
| Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice | Q24599945 | ||
| DNA methylation profiling of human chromosomes 6, 20 and 22 | Q24607522 | ||
| The many roles of histone deacetylases in development and physiology: implications for disease and therapy | Q24628821 | ||
| Regulation of chromatin by histone modifications | Q24635070 | ||
| Expression of MicroRNA-146a in osteoarthritis cartilage | Q24657447 | ||
| miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1 | Q24657866 | ||
| NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses | Q24670080 | ||
| Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation | Q24679746 | ||
| Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption | Q24816674 | ||
| The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing | Q28116655 | ||
| The complex language of chromatin regulation during transcription | Q28131748 | ||
| Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis | Q79318170 | ||
| Toward a human epigenome | Q79390371 | ||
| Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation | Q79676737 | ||
| DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes | Q79711739 | ||
| MicroRNA expression in zebrafish embryonic development | Q28253126 | ||
| Genomic DNA methylation: the mark and its mediators | Q28290773 | ||
| Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells | Q28295332 | ||
| Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks | Q28474080 | ||
| Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis | Q28505748 | ||
| A novel tumor necrosis factor alpha-responsive CCAAT/enhancer binding protein site regulates expression of the cartilage-derived retinoic acid-sensitive protein gene in cartilage | Q28567599 | ||
| Phenotypic plasticity and the epigenetics of human disease | Q29614515 | ||
| Sirtuins in mammals: insights into their biological function | Q29615248 | ||
| Stability and flexibility of epigenetic gene regulation in mammalian development | Q29615922 | ||
| Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells | Q30441798 | ||
| Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes | Q30931885 | ||
| Regional differences in chondrocyte metabolism in osteoarthritis: a detailed analysis by laser capture microdissection | Q33312600 | ||
| Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. | Q33346368 | ||
| MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses | Q33588972 | ||
| Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis | Q33637251 | ||
| Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. | Q33706862 | ||
| Epigenetic transgenerational actions of environmental factors in disease etiology | Q33766998 | ||
| MicroRNA-140 plays dual roles in both cartilage development and homeostasis | Q33885698 | ||
| Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes. | Q34042514 | ||
| SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. | Q34072652 | ||
| Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis | Q34407611 | ||
| ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro | Q34407615 | ||
| DNA methylation and the regulation of gene transcription | Q34578086 | ||
| The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis | Q34626232 | ||
| NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance | Q34684804 | ||
| Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis | Q34766857 | ||
| MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis | Q34984847 | ||
| Regulation of chondrocyte gene expression by osteogenic protein-1. | Q35092975 | ||
| Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling. | Q35096652 | ||
| MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. | Q35114604 | ||
| Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. | Q35170021 | ||
| Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes | Q35215468 | ||
| Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation | Q35964246 | ||
| Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention | Q36171836 | ||
| The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance | Q36426224 | ||
| DNA methylation in osteoarthritic chondrocytes: a new molecular target | Q36565318 | ||
| Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes | Q36728953 | ||
| Dicer-dependent pathways regulate chondrocyte proliferation and differentiation | Q36882995 | ||
| Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140. | Q36990769 | ||
| Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. | Q37021544 | ||
| The regulation of matrix metalloproteinases and their inhibitors. | Q37079430 | ||
| Inherited variation at the epigenetic level: paramutation from the plant to the mouse | Q37086512 | ||
| A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes | Q37355387 | ||
| Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis | Q37380755 | ||
| Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis. | Q37608884 | ||
| Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. | Q37609032 | ||
| NF-kappaB signaling: multiple angles to target OA. | Q37701897 | ||
| Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis? | Q37701905 | ||
| Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis | Q37730927 | ||
| Interplay between microRNAs and the epigenetic machinery: an intricate network | Q37759740 | ||
| Osteoarthritis year 2010 in review: pathomechanisms | Q37842858 | ||
| MicroRNA biogenesis and regulation of bone remodeling | Q37884118 | ||
| Differential hypermethylation of SOCS genes in ovarian and breast carcinomas. | Q38336792 | ||
| MicroRNA regulation associated chondrogenesis of mouse MSCs grown on polyhydroxyalkanoates | Q39526269 | ||
| Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level. | Q39752388 | ||
| Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. | Q39978569 | ||
| The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells | Q40308810 | ||
| Sox9 and p300 cooperatively regulate chromatin-mediated transcription | Q40383677 | ||
| MicroRNA-140 and the silencing of osteoarthritis | Q40817365 | ||
| Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration | Q41577617 | ||
| Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes. | Q41965715 | ||
| DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes | Q42117977 | ||
| Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma | Q42488421 | ||
| DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage | Q43049079 | ||
| SIRT1 regulation of apoptosis of human chondrocytes | Q43284360 | ||
| Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction | Q43570416 | ||
| Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes | Q45329371 | ||
| Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis | Q46353226 | ||
| Assessment of the profiling microRNA expression of differentiated and dedifferentiated human adult articular chondrocytes | Q46656523 | ||
| Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment | Q46780418 | ||
| RNA induction and inheritance of epigenetic cardiac hypertrophy in the mouse | Q48748791 | ||
| Regulation of type II collagen expression by histone deacetylase in articular chondrocytes. | Q51027080 | ||
| Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage. | Q51946975 | ||
| The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13. | Q53524092 | ||
| Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter. | Q54517867 | ||
| Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. | Q54638931 | ||
| P433 | issue | 2 | |
| P921 | main subject | microRNA | Q310899 |
| cartilage | Q502730 | ||
| osteoarthritis | Q62736 | ||
| P304 | page(s) | 109-118 | |
| P577 | publication date | 2011-12-17 | |
| P1433 | published in | Trends in Molecular Medicine | Q15265842 |
| P1476 | title | Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis | |
| P478 | volume | 18 |
| Q60187947 | A Microarray Study of Articular Cartilage in Relation to Obesity and Severity of Knee Osteoarthritis |
| Q44713444 | A global increase in 5-hydroxymethylcytosine levels marks osteoarthritic chondrocytes |
| Q97523824 | A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway |
| Q38134331 | Advances and challenges in gene-based approaches for osteoarthritis |
| Q40286827 | An effective and efficient method of transfecting primary human chondrocytes in suspension |
| Q33880205 | Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis |
| Q36240634 | Attenuation of the progression of articular cartilage degeneration by inhibition of TGF-β1 signaling in a mouse model of osteoarthritis |
| Q38345989 | Cartilage tissue engineering: recent advances and perspectives from gene regulation/therapy |
| Q36111296 | Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis |
| Q38613955 | DNA Methylation in Osteoarthritis. |
| Q88726117 | DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes |
| Q41881337 | DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism. |
| Q33754990 | Decrease of miR-195 Promotes Chondrocytes Proliferation and Maintenance of Chondrogenic Phenotype via Targeting FGF-18 Pathway |
| Q38764119 | ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity |
| Q35752078 | Emerging targets in osteoarthritis therapy. |
| Q37562358 | Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis |
| Q37130898 | Epigenetic and microRNA regulation during osteoarthritis development |
| Q38210478 | Epigenetic-based immune intervention for rheumatic diseases |
| Q27010637 | Epigenetics advancing personalized nanomedicine in cancer therapy |
| Q38081554 | Epigenetics in osteoarthritis and its implication for future therapeutics |
| Q52682434 | Evidences for a New Role of miR-214 in Chondrogenesis. |
| Q53971850 | Extraction of high-quality RNA from human articular cartilage. |
| Q38642703 | Gene therapy for human osteoarthritis: principles and clinical translation |
| Q45750089 | Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients |
| Q36372904 | Identification of differentially methylated regions in new genes associated with knee osteoarthritis. |
| Q30100430 | Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage |
| Q37606976 | Inflammation and epigenetic regulation in osteoarthritis |
| Q90167828 | Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice |
| Q92802485 | Inhibition of microRNA-495 suppresses chondrocyte apoptosis through activation of the NF-κB signaling pathway by regulating CCL4 in osteoarthritis |
| Q51758619 | Interplay of Inflammatory Mediators with Epigenetics and Cartilage Modifications in Osteoarthritis. |
| Q35859901 | LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes |
| Q57458021 | Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development |
| Q90638365 | Mangiferin Relieves Lipopolysaccharide-Induced Injury by Up-Regulating miR-181a via Targeting PTEN in ATDC5 Cells |
| Q36846863 | Mechanical and IL-1β Responsive miR-365 Contributes to Osteoarthritis Development by Targeting Histone Deacetylase 4. |
| Q35942351 | MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors |
| Q36917893 | MicroRNA functions in osteogenesis and dysfunctions in osteoporosis |
| Q39020205 | MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes |
| Q33762372 | MicroRNA-29b Contributes to Collagens Imbalance in Human Osteoarthritic and Dedifferentiated Articular Chondrocytes |
| Q36983759 | MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis |
| Q38253187 | MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis |
| Q47427042 | MicroRNA‑206 contributes to the progression of steroid‑induced avascular necrosis of the femoral head by inducing osteoblast apoptosis by suppressing programmed cell death 4. |
| Q47104080 | New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis |
| Q26777901 | Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation |
| Q38091122 | Perspectives on epigenetic-based immune intervention for rheumatic diseases |
| Q36923747 | Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis. |
| Q36747491 | RNA Interference Mediated Interleukin-1β Silencing in Inflamed Chondrocytes Decreases Target and Downstream Catabolic Responses |
| Q34014106 | Recent progress in osteoarthritis research |
| Q36742102 | Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites |
| Q48375231 | Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis. |
| Q38103811 | Regulatory mechanisms for the development of growth plate cartilage |
| Q38105988 | Review: the role of microRNAs in osteoarthritis and chondrogenesis |
| Q42733032 | Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro |
| Q26865460 | Roles of microRNAs in prenatal chondrogenesis, postnatal chondrogenesis and cartilage-related diseases |
| Q55693239 | Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis. |
| Q33637249 | Significance of epigenetic landscape in cartilage regeneration from the cartilage development and pathology perspective |
| Q41779548 | Silencing of microRNA-138-5p promotes IL-1β-induced cartilage degradation in human chondrocytes by targeting FOXC1: miR-138 promotes cartilage degradation |
| Q92776105 | Skeletal Muscle Wasting and Its Relationship With Osteoarthritis: a Mini-Review of Mechanisms and Current Interventions |
| Q34693318 | Sox9-regulated miRNA-574-3p inhibits chondrogenic differentiation of mesenchymal stem cells |
| Q60961477 | Systematic Analysis of Transcriptomic Profile of Chondrocytes in Osteoarthritic Knee Using Next-Generation Sequencing and Bioinformatics |
| Q34763126 | TGF-β signaling and the development of osteoarthritis |
| Q36407872 | Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis |
| Q38609284 | The Disease-Modifying Effects of Hyaluronan in the Osteoarthritic Disease State |
| Q58760737 | The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets |
| Q38166991 | The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments? |
| Q33565236 | The role of DNA methylation in common skeletal disorders |
| Q38245620 | Use of tissue engineering strategies to repair joint tissues in osteoarthritis: viral gene transfer approaches |
| Q36356966 | miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes |
| Q41910858 | miR-181a Modulates Chondrocyte Apoptosis by Targeting Glycerol-3-Phosphate Dehydrogenase 1-Like Protein (GPD1L) in Osteoarthritis. |
| Q42379009 | miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment |
| Q64066732 | miR‑146a‑5p expression is upregulated by the CXCR4 antagonist TN14003 and attenuates SDF‑1‑induced cartilage degradation |
| Q33766656 | p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis. |
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