The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing

scientific article published on 16 June 2015

The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2015NatCo...6.7386J
P356DOI10.1038/NCOMMS8386
P932PMC publication ID4480344
P698PubMed publication ID26077348
P5875ResearchGate publication ID278732859

P50authorLester F LauQ82746733
P2093author name stringKi-Hyun Kim
Joon-Il Jun
P2860cites workCCN2 expression by fibroblasts is not required for cutaneous tissue repairQ87040960
Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epitheliumQ24318277
CYR61 (CCN1) is essential for placental development and vascular integrityQ24540206
Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophagesQ24633369
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healingQ24633454
CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growthQ24647068
Cellular and molecular mechanisms of fibrosisQ24648892
Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitisQ24656280
The matricellular protein CCN1 is essential for cardiac developmentQ24678075
NETosis: how vital is it?Q26821976
Apoptotic cell clearance: basic biology and therapeutic potential.Q26825935
Neutrophil activity in chronic venous leg ulcers--a target for therapy?Q26999022
Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesionsQ28201451
Identification of a factor that links apoptotic cells to phagocytesQ28217034
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targetsQ28254386
Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61)Q28513880
Wound repair and regenerationQ29617949
Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestionQ30408786
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac moduleQ30444833
CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130CasQ33582805
Defective efferocytosis by alveolar macrophages in IPF patientsQ33649048
MFG-E8 regulates angiogenesis in cutaneous wound healingQ33826601
CCN1/CYR61: the very model of a modern matricellular protein.Q34027926
CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smokeQ34062984
Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8Q34120529
Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.Q34152999
A blast from the past: clearance of apoptotic cells regulates immune responses.Q34162195
Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activationQ34317397
Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute woundsQ34478664
Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cellsQ34529299
Cellular and molecular basis of wound healing in diabetesQ34625159
Reciprocal communication between endometrial stromal cells and macrophagesQ35136727
Neutrophil clearance: when the party is over, clean-up beginsQ35151051
CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB.Q35720021
The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null miceQ35789152
Higher levels of mucosal antibody to pneumococcal vaccine candidate proteins are associated with reduced acute otitis media caused by Streptococcus pneumoniae in young childrenQ35915846
Modulation of macrophage efferocytosis in inflammationQ35927561
The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6.Q36093753
Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis.Q36488532
Inflammation in wound repair: molecular and cellular mechanismsQ36735385
Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.Q36826814
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary diseaseQ37570289
Laminin binds specifically to sulfated glycolipidsQ37678904
Secondary necrosis: the natural outcome of the complete apoptotic programQ37802938
The paradox of the neutrophil's role in tissue injuryQ37811628
Monocyte and macrophage dynamics during atherogenesisQ37890185
Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammationQ37929022
Apoptotic cell death and efferocytosis in atherosclerosisQ37983554
Defective phagocytosis in airways diseaseQ37999769
TAM receptors, Gas6, and protein S: roles in inflammation and hemostasisQ38193420
Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functionsQ38337503
Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cellsQ38337807
Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twinsQ38518176
The isolation and characterization of murine macrophagesQ39485692
The neutrophilic leukocyte in wound repair a study with antineutrophil serumQ40326337
Proteolysis of CCN1 by plasmin: functional implicationsQ40355376
A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells.Q40464984
Impaired clearance of apoptotic cells from cystic fibrosis airwaysQ43917491
Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltrationQ44043390
Mouse bone marrow contains large numbers of functionally competent neutrophilsQ44705291
Excessive neutrophils characterize chronic pressure ulcersQ44898844
Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient miceQ44904989
The matri-cellular proteins 'cysteine-rich, angiogenic-inducer, 61' and 'connective tissue growth factor' are regulated in experimentally-induced sepsis with multiple organ dysfunctionQ45189914
Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells.Q51664433
Neutrophil function in the healing wound: adding insult to injury?Q54307319
Differential roles of macrophages in diverse phases of skin repair.Q54440277
A possible mechanism of basic fibroblast growth factor-promoted scarless wound healing: the induction of myofibroblast apoptosis.Q54526837
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosisQ59061176
Accelerated wound closure in neutrophil-depleted miceQ73180171
Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repairQ74199089
Use of Ly6G-specific monoclonal antibody to deplete neutrophils in miceQ81332054
P407language of work or nameEnglishQ1860
P921main subjectwound healingQ1509074
P304page(s)7386
P577publication date2015-06-16
P1433published inNature CommunicationsQ573880
P1476titleThe matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing
P478volume6

Reverse relations

cites work (P2860)
Q41636790Accelerated Healing of Diabetic Wounds Treated with L-Glutamic acid Loaded Hydrogels Through Enhanced Collagen Deposition and Angiogenesis: An In Vivo Study
Q54979276Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs.
Q41204170Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance
Q42551595CCN1 in hepatobiliary injury repair.
Q90117791CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling
Q30803044CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation
Q47246640CCN1/Cyr61 enhances the function of hepatic stellate cells in promoting the progression of hepatocellular carcinoma
Q42314688CCN2 induces cellular senescence in fibroblasts.
Q50990629CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis.
Q50060196CCN4/WISP1 controls cutaneous wound healing by modulating proliferation, migration and ECM expression in dermal fibroblasts via α5β1 and TNFα.
Q35922588CTGF/CCN2 Postconditioning Increases Tolerance of Murine Hearts towards Ischemia-Reperfusion Injury
Q26751449Cell surface receptors for CCN proteins
Q38936566Clearance of apoptotic neutrophils and resolution of inflammation
Q38812171Construction and Analysis of an Allelic Series of Ccn1 Knockin Mice.
Q91872188Cysteine-Rich Angiogenic Inducer 61 Serves as a Potential Serum Biomarker for the Remission of Adult-Onset Still's Disease
Q64271132Cysteine-rich 61 (Cyr61): a biomarker reflecting disease activity in rheumatoid arthritis
Q99248364Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss
Q46488212Design and Analysis of CCN Gene Activity Using CCN Knockout Mice Containing LacZ Reporters
Q47267479Drug delivery and tissue engineering to promote wound healing in the immunocompromised host: Current challenges and future directions
Q64121539Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling
Q39123271Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses
Q39178399From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins
Q61810426Gene Expression Profiling in Ischemic Postconditioning to Alleviate Mouse Liver Ischemia/Reperfusion Injury
Q48176405Incorporation of resident macrophages in engineered tissues: Multiple cell type response to microenvironment controlled macrophage-laden gelatine hydrogels.
Q39013196Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity
Q55049931Neutrophils in Tissue Trauma of the Skin, Bone, and Lung: Two Sides of the Same Coin.
Q58714925Pulmonary influenza A virus infection leads to suppression of the innate immune response to dermal injury
Q92309465RNA Expression Profile and Alternative Splicing Signatures of Genistein-Treated Breeder Hens Revealed by Hepatic Transcriptomic Analysis
Q50895121Recombinant CCN1 prevents hyperoxia-induced lung injury in neonatal rats.
Q50145564Regulation and bioactivity of the CCN family of genes and proteins in obesity and diabetes.
Q30822546S. aureus blocks efferocytosis of neutrophils by macrophages through the activity of its virulence factor alpha toxin.
Q55172404Salmon cartilage proteoglycan promotes the healing process of Staphylococcus aureus-infected wound.
Q50096790Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair.
Q91801206Sphingosine-1-Phosphate Facilitates Skin Wound Healing by Increasing Angiogenesis and Inflammatory Cell Recruitment with Less Scar Formation
Q91908270The CCN1 (CYR61) protein promotes skin growth by enhancing epithelial-mesenchymal transition during skin expansion
Q50134163The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF-ERK signaling.
Q64230504The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis
Q54962838The matricellular protein CCN1 in tissue injury repair.
Q92002456The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation
Q93367533Wound Healing: A Cellular Perspective

Search more.