Transient regulatory T-cells: a state attained by all activated human T-cells.

scientific article published on 19 December 2006

Transient regulatory T-cells: a state attained by all activated human T-cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CLIM.2006.10.014
P932PMC publication ID1868523
P698PubMed publication ID17185041
P5875ResearchGate publication ID6615505

P50authorNitin J KarandikarQ56285632
Sterling B OrtegaQ59682897
P2093author name stringVinodh Pillai
C K Wang
P2860cites workScurfin (FOXP3) acts as a repressor of transcription and regulates T cell activationQ24291515
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cellsQ24298812
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cellsQ24306205
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cellsQ24645614
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infectionQ27469828
T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection.Q27469830
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
11-color, 13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T-cell receptor diversityQ28200074
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsQ29618394
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-selfQ29619194
A new "Logicle" display method avoids deceptive effects of logarithmic scaling for low signals and compensated dataQ31036367
Interpreting flow cytometry data: a guide for the perplexedQ31045140
A peripheral circulating compartment of natural naive CD4 TregsQ33865874
De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cellsQ33932462
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell developmentQ34597933
Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosisQ34789216
Functional avidity directs T-cell fate in autoreactive CD4+ T cellsQ35848366
CD4+ Tregs and immune controlQ35936484
Qa-1 restriction of CD8+ suppressor T cellsQ35936489
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.Q36078042
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cellsQ36228688
CD4+ regulatory cells as a potential immunotherapyQ36251271
CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease statusQ36399748
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitisQ36403300
Regulatory T-cell compartmentalization and traffickingQ36421407
FOXP3: of mice and men.Q36427333
The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.Q41998069
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ TregsQ42181372
Molecular mechanisms underlying FOXP3 induction in human T cellsQ42491664
The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients.Q45304800
Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis.Q45952178
Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivityQ47265853
Persistence of naive CD45RA+ regulatory T cells in adult life.Q51986549
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.Q52932694
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.Q54645452
Can super-antibody drugs be tamed?Q56674040
Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonistQ56903962
FOXP3 Identifies Regulatory CD25brightCD4+ T Cells in Rheumatic JointsQ57349726
CD4+CD25+T Cells in Skin Lesions of Patients with Cutaneous Leishmaniasis Exhibit Phenotypic and Functional Characteristics of Natural Regulatory T CellsQ57934785
Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell levelQ60311694
Seventeen-colour flow cytometry: unravelling the immune systemQ62577376
High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assayQ76376758
Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis BQ79755080
Regulatory/suppressor T cells in health and diseaseQ80806146
Inducing and expanding regulatory T cell populations by foreign antigenQ81392563
CD28 superagonists put a break on autoimmunity by preferentially activating CD4+CD25+ regulatory T cellsQ81596148
Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) miceQ82715228
London's disastrous drug trial has serious side effects for researchQ82918022
P433issue1
P304page(s)18-29
P577publication date2006-12-19
P1433published inClinical ImmunologyQ15752921
P1476titleTransient regulatory T-cells: a state attained by all activated human T-cells
P478volume123

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cites work (P2860)
Q359816031,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region
Q38872469A Bacterial Artificial Chromosome Reporter System for Expression of the Human FOXP3 Gene in Mouse Regulatory T-Cells
Q34461203A cancer vaccine induces expansion of NY-ESO-1-specific regulatory T cells in patients with advanced melanoma.
Q36191738A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function
Q35028105A comprehensive and quantitative analysis of the major specificities in rabbit antithymocyte globulin preparations
Q24304263A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells
Q37064737A pharmacologic perspective on newly emerging T-cell manipulation technologies
Q34696683A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells
Q36362241Activation-induced FoxP3 expression regulates cytokine production in conventional T cells stimulated with autologous dendritic cells
Q33299427Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo
Q56899929Allogeneic induced human FOXP3(+)IFN-gamma(+) T cells exhibit selective suppressive capacity
Q52732451Alterations in T-lymphocyte sub-set profiles and cytokine secretion by PBMC of systemic lupus erythematosus patients upon in vitro exposure to organochlorine pesticides.
Q30300277Analysis of cytokine production by peanut-reactive T cells identifies residual Th2 effectors in highly allergic children who received peanut oral immunotherapy
Q37151149Antagonism of histamine H4 receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis.
Q80512153Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation
Q42953763Attack on the clones? Human FOXP3 detection by PCH101, 236A/E7, 206D, and 259D reveals 259D as the outlier with lower sensitivity
Q37347729Bronchoalveolar immunologic profile of acute human lung transplant allograft rejection
Q50281162CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures.
Q35025435CD4(+)CD62L(+) central memory T cells can be converted to Foxp3(+) T cells
Q48259792CD4+ regulatory T cells in gastric cancer mucosa are proliferating and express high levels of IL-10 but little TGF-β.
Q37794623CD4+ regulatory T cells in solid organ transplantation
Q36978507CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis.
Q89944708CD4+FOXP3+ T Cells in Rheumatoid Arthritis Bone Marrow Are Partially Impaired
Q35506606CD8(+)/FOXP3(+)-ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study
Q33889097CD8+ Tregs in lupus, autoimmunity, and beyond
Q54462329Characterization of circulating CD4+CD25high regulatory T cells in men with chronic prostatitis/chronic pelvic pain syndrome.
Q35564025Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation
Q35926395Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate
Q40301941Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year
Q37944565Cutaneous T-cell lymphoma: 2011 update on diagnosis, risk-stratification, and management
Q36126324Cytomegalovirus Infection Leads to Development of High Frequencies of Cytotoxic Virus-Specific CD4+ T Cells Targeted to Vascular Endothelium.
Q34503547DC expressing transgene Foxp3 are regulatory APC.
Q52924279DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.
Q46391168DNA methylation controls Foxp3 gene expression
Q50872929Deregulation from CD4+ memory T cells to regulatory cells in patients with chronic renal failure: a pilot study.
Q56890349Description of CD8 Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer
Q41754216Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells
Q53498602Differentiation of naive CD4+ T cells into CD4+CD25+FOXP3+ regulatory T cells by continuous antigen stimulation.
Q39016358Effect of cell density and HLA-DR incompatibility on T-cell proliferation and forkhead box P3 expression in human mixed lymphocyte reaction
Q35276622Efficacy, safety, and cost-effectiveness of glatiramer acetate in the treatment of relapsing-remitting multiple sclerosis
Q83125659Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
Q54345023Equine CD4(+) CD25(high) T cells exhibit regulatory activity by close contact and cytokine-dependent mechanisms in vitro.
Q42589743Ethylenecarbodiimide-coupled allogeneic antigen presenting cells induce human CD4+ regulatory T cells
Q41190379Evaluation of CD4+ CD25+ FoxP3+ Regulatory T cells and FoxP3 and CTLA-4 gene Expression in Patients wwith Newly Diagnosed Tuberculosis in Northeast of Iran
Q34699537Expression of a broad array of negative costimulatory molecules and Blimp-1 in T cells following priming by HIV-1 pulsed dendritic cells
Q33644550FOXP3 expression is upregulated in CD4T cells in progressive HIV-1 infection and is a marker of disease severity
Q33320522FOXP3 promoter demethylation reveals the committed Treg population in humans.
Q84278927FOXP3+CD25- tumor cells with regulatory function in Sézary syndrome
Q35566145FoxP3 enhances HIV-1 gene expression by modulating NFkappaB occupancy at the long terminal repeat in human T cells
Q28115088Foxp3 is critical for human natural CD4+CD25+ regulatory T cells to suppress alloimmune response
Q42518281Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus
Q36984057Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation
Q33312509GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.
Q64230492Generation and Immune Regulation of CD4CD25Foxp3 T Cells in Chronic Obstructive Pulmonary Disease
Q36938160Generation and function of induced regulatory T cells
Q34996186Generation of human regulatory T cells de novo with suppressive function prevent xenogeneic graft versus host disease
Q40055892Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.
Q35742927Glucocorticoids increase CD4CD25 cell percentage and Foxp3 expression in patients with multiple sclerosis.
Q34019821Helios expression is a marker of T cell activation and proliferation.
Q36299565Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP.
Q33931235High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population
Q36919214Histone deacetylase inhibitors and transplantation.
Q37596517How do regulatory T cells work?
Q33525560Human CD4 memory T cells can become CD4+IL-9+ T cells
Q37524383Human FOXP3+ regulatory T cells in transplantation
Q37405703Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function
Q38881545Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-β.
Q85089606Human peripheral blood CD8+ CD28- T cells of renal allograft recipients do not express FOXP3 protein
Q34636235Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells.
Q36171406Human regulatory T cells: a unique, stable thymic subset or a reversible peripheral state of differentiation?
Q54427491Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire.
Q51887184Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-γ+ and FOXP3+ T cells with potent suppressive function.
Q37198900IL-15 acts as a potent inducer of CD4(+)CD25(hi) cells expressing FOXP3.
Q54562647IL-9 contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma.
Q34037796Immune response to Bifidobacterium bifidum strains support Treg/Th17 plasticity
Q51212581In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol.
Q47929049In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity.
Q44638209Increase in tumour-infiltrating lymphocytes with regulatory T cell immunophenotypes and reduced zeta-chain expression in nasopharyngeal carcinoma patients.
Q36329777Increased Intraepithelial Vα24 Invariant NKT Cells in the Celiac Duodenum
Q36059631Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype
Q87388246Induction of antigen-specific human T suppressor cells by membrane and soluble ILT3
Q36994057Induction of regulatory T-cells from memory T-cells is perturbed during acute exacerbation of multiple sclerosis
Q33712534Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.
Q36688093Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma
Q39332952Inhibition of activation induced CD154 on CD4+ CD25- cells: a valid surrogate for human Treg suppressor function
Q37037612Inhibitory CD8+ T cells in autoimmune disease
Q42042533Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation
Q36608731Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer
Q35123215Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-β and induce Tregs development via TGF-β.
Q35077586Markers of T cell infiltration and function associate with favorable outcome in vascularized high-grade serous ovarian carcinoma.
Q36791390Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis
Q38008361Molecular mechanisms of treg-mediated T cell suppression
Q37952092Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cells
Q28270037Monoclonal antibodies and other biologic agents in the treatment of asthma
Q37973770Monogenic autoimmunity
Q54377708Mucosal administration of the B subunit of E. coli heat-labile enterotoxin promotes the development of Foxp3-expressing regulatory T cells.
Q26829692Panel 5: Microbiology and immunology panel
Q92286626Peptidase inhibitor 16 identifies a human regulatory T-cell subset with reduced FOXP3 expression over the first year of recent onset type 1 diabetes
Q92798698Peripheral blood CD4+ T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease
Q37076945Peripherally induced tregs - role in immune homeostasis and autoimmunity
Q37729634Plasticity is the differentiated state of CD4 T cells.
Q38069412Prognostic significance of graft Foxp3 expression in renal transplant recipients: a critical review and attempt to reconcile discrepancies
Q41848701Proliferation and foxp3 expression in virus-specific memory CD8+ T lymphocytes
Q84588320Prolonged lymphocyte depletion by single-dose rabbit anti-thymocyte globulin and alemtuzumab in kidney transplantation
Q36842568Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
Q45148312Recent thymic origin, differentiation, and turnover of regulatory T cells
Q37474900Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells
Q41849574Regulation gone wrong: a subset of Sézary patients have malignant regulatory T cells
Q42554303Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.
Q37903852Regulatory T cells in gastrointestinal tumors
Q37129619Regulatory T cells in systemic lupus erythematosus: past, present and future
Q51765736Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis.
Q42786356Regulatory T cells: stability revisited
Q35384216Regulatory T-cell Trafficking: From Thymic Development to Tumor-Induced Immune Suppression
Q34464401Regulatory T-cells and associated pathways in metastatic renal cell carcinoma (mRCC) patients undergoing DC-vaccination and cytokine-therapy
Q37914338Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis
Q40013872STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.
Q33873997Sirolimus Increases T-Cell Abundance in the Sun Exposed Skin of Kidney Transplant Recipients
Q38088063Subpopulations of helper T lymphocytes in tuberculous pleurisy
Q33977826Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses
Q37967572Suppression assays with human T regulatory cells: a technical guide.
Q53162837Suppressor Properties of Human CD8(+)CD28(-) T Cells in Mixed Leukocyte Reaction are not Affected by CsA and RAPA.
Q33488520Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors
Q36967375T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation
Q37018222T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: facts and controversies.
Q45365327T-regulatory cells infected with feline immunodeficiency virus up-regulate programmed death-1 (PD-1).
Q37528532TGF-β Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner
Q37250644The Nature of Increased Circulating CD4CD25Foxp3 T Cells in Patients with Systemic Lupus Erythematosus: A Novel Hypothesis
Q38856516The Role of IFN-alpha in Experimental and Clinical Uveitis
Q84923161The dynamic changes of T-bet(+)/GATA-3(+) and RORgammat(+)/FOXP3(+) cells in recipient spleens and grafts after rat orthotopic liver transplantation
Q46046855The effect of various disease-modifying anti-rheumatic drugs on the suppressive function of CD4⁺CD25⁺ regulatory T cells
Q44041381The ex vivo induction of human CD103⁺ CD25hi Foxp3⁺ CD4⁺ and CD8⁺ Tregs is IL-2 and TGF-β1 dependent.
Q42954783The human "Treg MLR": immune monitoring for FOXP3+ T regulatory cell generation.
Q84443643The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients
Q43233982The importance of the nurse cells and regulatory cells in the control of T lymphocyte responses
Q38129079The role of FOXP3 in regulating immune responses
Q37272092The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease
Q30371308The role of regulatory T cells in atopic dermatitis.
Q27004368The role of regulatory T cells in the pathogenesis of sepsis and its clinical implication
Q34103905The role of the thymus in tolerance
Q30423165The vaccine-site microenvironment induced by injection of incomplete Freund's adjuvant, with or without melanoma peptides
Q55287352Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3.
Q27008946Treg functional stability and its responsiveness to the microenvironment
Q34001211Tumor antigen epitopes interpreted by the immune system as self or abnormal-self differentially affect cancer vaccine responses
Q97537455Tumor infiltrating T cells influence prognosis in stage I-III non-small cell lung cancer
Q33882469Type-I IFN signaling suppresses an excessive IFN-gamma response and thus prevents lung damage and chronic inflammation during Pneumocystis (PC) clearance in CD4 T cell-competent mice
Q26863525Ubiquitin-dependent regulation of Foxp3 and Treg function
Q52677986Unravelling the molecular basis for regulatory T-cell plasticity and loss of function in disease.
Q46952293Upregulation of CD200 is associated with Foxp3+ regulatory T cell expansion and disease progression in acute myeloid leukemia
Q28249415Use of epigenetic modification to induce FOXP3 expression in naïve T cells

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