E5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation

scientific article published in April 1996

E5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.70.4.2420-2430.1996
P932PMC publication ID190085
P698PubMed publication ID8642670

P2093author name stringR Schlegel
J Anders
M Mense
J Sparkowski
P2860cites workVacuolar H(+)-ATPase mutants transform cells and define a binding site for the papillomavirus E5 oncoproteinQ28115609
E5 open reading frame of bovine papillomavirus type 1 encodes a transforming geneQ28286988
Animal papillomaviruses.Q33626481
The E5 oncoprotein of bovine papillomavirus binds to a 16 kd cellular proteinQ33916978
Translation of open reading frame E5 of bovine papillomavirus is required for its transforming activityQ35595257
Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.Q35846414
Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein.Q35849030
Membrane-anchored form of v-sis/PDGF-B induces mitogenesis without detectable PDGF receptor autophosphorylationQ36529579
Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signalingQ36550896
The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformationQ36622401
Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transfected cellsQ36634049
Mutation of the bovine papillomavirus E5 oncoprotein at amino acid 17 generates both high- and low-transforming variantsQ36635620
Transformation-specific interaction of the bovine papillomavirus E5 oncoprotein with the platelet-derived growth factor receptor transmembrane domain and the epidermal growth factor receptor cytoplasmic domainQ36651868
A glutamine residue in the membrane-associating domain of the bovine papillomavirus type 1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H(+)-ATPaseQ36656196
Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 proteinQ36690316
The conserved C-terminal domain of the bovine papillomavirus E5 oncoprotein can associate with an alpha-adaptin-like molecule: a possible link between growth factor receptors and viral transformationQ36824208
44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acidsQ36846314
Evidence that the deep keratin filament systems of the Xenopus embryo act to ensure normal gastrulation.Q37208255
Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell linesQ37611813
E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cellsQ37619573
Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirementsQ37669730
In vitro induction of continuous acute promyelocytic leukemia cell lines by Friend or Abelson murine leukemia virusQ40222820
Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming proteinQ41080345
An intact PDGF signaling pathway is required for efficient growth transformation of mouse C127 cells by the bovine papillomavirus E5 protein.Q41351225
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cellsQ42807469
The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptorsQ42835148
Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped by in situ hybridizationQ45383630
A quantitative in vitro focus assay for bovine papilloma virusQ45803536
Characterization of bovine papillomavirus type 1-transformed clones which show distinct transformed phenotypes.Q53515084
The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polypeptide.Q54144933
Genetic analysis of the 3' early region transformation and replication functions of bovine papillomavirus type 1.Q64956444
Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cellsQ68090789
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
transmembrane proteinQ424204
P304page(s)2420-2430
P577publication date1996-04-01
P1433published inJournal of VirologyQ1251128
P1476titleE5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation
P478volume70

Reverse relations

cites work (P2860)
Q81298973Are transforming properties of the bovine papillomavirus E5 protein shared by E5 from high-risk human papillomavirus type 16?
Q33482628Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor
Q33575831Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor beta receptor
Q28594481Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding
Q43581315Bovine papillomavirus oncoprotein E5 affects the arachidonic acid metabolism in cells.
Q33835105Cooperative transformation and coexpression of bovine papillomavirus type 1 E5 and E7 proteins
Q38311773ErbB4 (JM-b/CYT-1)-induced expression and phosphorylation of c-Jun is abrogated by human papillomavirus type 16 E5 protein
Q41820272Golgi alkalinization by the papillomavirus E5 oncoprotein
Q35895171Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 protein
Q40794484Identification of the transmembrane dimer interface of the bovine papillomavirus E5 protein
Q22010594Mechanism of action and in vivo role of platelet-derived growth factor
Q33183198Mechanisms of cell transformation by papillomavirus E5 proteins
Q41361382Multiplicity of uses of monoclonal antibodies that define papillomavirus linear immunodominant epitopes
Q40638007Oligomerization of the E5 protein of human papillomavirus type 16 occurs through multiple hydrophobic regions.
Q35057000Organelle acidification and disease
Q40471258Productive interaction between transmembrane mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor beta receptor.
Q39582036Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation.
Q40245388Suprabasal overexpression of beta-1 integrin is induced by bovine papillomavirus type 1.
Q34754347The E5 proteins
Q33644980The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells
Q33180948The platelet-derived growth factor beta receptor as a target of the bovine papillomavirus E5 protein
Q24530182The vacuolar H+-ATPase: a universal proton pump of eukaryotes
Q41374895Virocrine transformation
Q42518739c-Src activation by the E5 oncoprotein enables transformation independently of PDGF receptor activation

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