Phosphodiesterase 5a Inhibition with Adenoviral Short Hairpin RNA Benefits Infarcted Heart Partially through Activation of Akt Signaling Pathway and Reduction of Inflammatory Cytokines

scientific article published on 28 December 2015

Phosphodiesterase 5a Inhibition with Adenoviral Short Hairpin RNA Benefits Infarcted Heart Partially through Activation of Akt Signaling Pathway and Reduction of Inflammatory Cytokines is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1045766L
P356DOI10.1371/JOURNAL.PONE.0145766
P932PMC publication ID4692549
P698PubMed publication ID26709517
P5875ResearchGate publication ID288658916

P2093author name stringJian Zhang
Zhe Jin
Dong Zhao
Yigang Wang
Longhu Li
Christian Paul
P2860cites workDevelopmental changes in the delayed rectifier K+ channels in mouse heart.Q52200708
Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)Q59192167
Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertensionQ71606973
Natural history and patterns of current practice in heart failure. The Studies of Left Ventricular Dysfunction (SOLVD) InvestigatorsQ72932823
Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failureQ73168133
Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signalingQ83323467
Therapeutic potential of PDE modulation in treating heart diseaseQ27005761
Cyclic nucleotide phosphodiesterases: molecular regulation to clinical useQ28263273
cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytesQ28577644
Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in miceQ30548444
Role of phosphodiesterase-5 inhibitors in heart failure: emerging data and concepts.Q30575578
Inhibition of eNOS/sGC/PKG Pathway Decreases Akt Phosphorylation Induced by Kainic Acid in Mouse HippocampusQ33717172
The role of anti-cytokine therapy in the failing heartQ34223016
Sildenafil attenuates inflammation and oxidative stress in pelvic ganglia neurons after bilateral cavernosal nerve damageQ34486470
Inflammatory mediators and the failing heart: past, present, and the foreseeable futureQ35011415
Phosphodiesterase type 5 and high altitude pulmonary hypertension.Q35537900
Adenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarctionQ35994136
Navigating the crossroads of coronary artery disease and heart failure.Q36591047
Overview of PDEs and their regulationQ36739122
The role of PDE5-inhibitors in cardiopulmonary disorders: from basic evidence to clinical development.Q36907334
Phosphodiesterase type 5: expanding roles in cardiovascular regulationQ37015149
Modulation of cGMP in heart failure: a new therapeutic paradigmQ37329891
Ventricular remodeling after myocardial infarction. Experimental observations and clinical implicationsQ37850831
Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivoQ40157495
Reperfusion in acute myocardial infarction: effect of timing and modulating factors in experimental modelsQ40800043
Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricleQ41265653
Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST).Q43586296
Nitric oxide regulates AKT phosphorylation and nuclear translocation in cultured retinal cells.Q44405169
Effect of 710 nm visible light irradiation on neurite outgrowth in primary rat cortical neurons following ischemic insultQ44949237
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophyQ45235067
Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunctionQ45887723
Cytokine gene expression after myocardial infarction in rat hearts: possible implication in left ventricular remodelingQ47785069
Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons.Q48393208
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
P304page(s)e0145766
P577publication date2015-12-28
P1433published inPLOS OneQ564954
P1476titlePhosphodiesterase 5a Inhibition with Adenoviral Short Hairpin RNA Benefits Infarcted Heart Partially through Activation of Akt Signaling Pathway and Reduction of Inflammatory Cytokines
P478volume10

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Q40073257An epigenome-wide association study of inflammatory response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network
Q52536411DNA methylation as a marker of response in rheumatoid arthritis.
Q35964552The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression

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