Adenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarction

scientific article

Adenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPHEART.00339.2011
P932PMC publication ID3362110
P698PubMed publication ID22447941
P5875ResearchGate publication ID221976634

P2093author name stringGang Lu
Muhammad Ashraf
Linlin Wang
Husnain Kh Haider
Longhu Li
P2860cites workMyocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplastyQ74190220
Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signalingQ83323467
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesteraseQ24336601
Cyclic nucleotide phosphodiesterases: molecular regulation to clinical useQ28263273
cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytesQ28577644
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signalingQ29615163
Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathwayQ30273656
Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in miceQ30548444
Apoptosis: the germs of deathQ33772652
Cyclic nucleotide phosphodiesterases: relating structure and functionQ34047795
Phosphodiesterase inhibition with tadalafil provides longer and sustained protection of stem cellsQ34357737
Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfideQ34503391
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathwaysQ34530552
Biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclasesQ34599923
The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in miceQ35015659
Phosphodiesterase type 5 and high altitude pulmonary hypertension.Q35537900
Type 5 phosphodiesterase inhibition in heart failure and pulmonary hypertensionQ36203104
Navigating the crossroads of coronary artery disease and heart failure.Q36591047
Overview of PDEs and their regulationQ36739122
Cardiovascular cGMP-generating systems in physiological and pathological conditions.Q36754532
Phosphodiesterase regulation of nitric oxide signalingQ36805849
Short hairpin RNA interference therapy for ischemic heart diseaseQ36853941
Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytesQ37012737
Phosphodiesterase type 5: expanding roles in cardiovascular regulationQ37015149
Long-acting phosphodiesterase-5 inhibitor, tadalafil, induces sustained cardioprotection against lethal ischemic injuryQ37264402
Modulation of cGMP in heart failure: a new therapeutic paradigmQ37329891
Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5).Q38336160
Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivoQ40157495
Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricleQ41265653
Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failureQ42507993
Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.Q44907848
Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in miceQ44935527
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophyQ45235067
Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunctionQ45887723
Developmental changes in the delayed rectifier K+ channels in mouse heart.Q52200708
Signal transduction by cGMP in heart.Q54759025
Long-Term Trends in the Incidence of and Survival with Heart FailureQ57073236
Natural history and patterns of current practice in heart failure. The Studies of Left Ventricular Dysfunction (SOLVD) InvestigatorsQ72932823
P433issue10
P921main subjectAdenoviridaeQ193447
P304page(s)H2112-21
P577publication date2012-03-23
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titleAdenoviral short hairpin RNA therapy targeting phosphodiesterase 5a relieves cardiac remodeling and dysfunction following myocardial infarction
P478volume302

Reverse relations

cites work (P2860)
Q36128551Cardiac role of cyclic-GMP hydrolyzing phosphodiesterase type 5: from experimental models to clinical trials
Q38191440Exercise training in adverse cardiac remodeling
Q35879351Phosphodiesterase 5a Inhibition with Adenoviral Short Hairpin RNA Benefits Infarcted Heart Partially through Activation of Akt Signaling Pathway and Reduction of Inflammatory Cytokines
Q34639920Protein kinase G1 α overexpression increases stem cell survival and cardiac function after myocardial infarction
Q45354313Tadalafil, a long acting phosphodiesterase inhibitor, promotes bone marrow stem cell survival and their homing into ischemic myocardium for cardiac repair

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