Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability

scientific article published on 21 February 2012

Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-11-2209
P932PMC publication ID3328627
P698PubMed publication ID22354749

P2093author name stringShirley Kwok
John P Higgins
Susan M Bailey
James D Brooks
J Martin Brown
Diana A Chernikova
Jennifer A Dorth
Olga V Razorenova
Monica Nicolau
Sophia B Chernikova
Brock J Sishc
John C Game
P2860cites workCDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processingQ24310547
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expressionQ24318500
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cellsQ24321262
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaksQ24651854
Chromatid cohesion defects may underlie chromosome instability in human colorectal cancersQ24656162
Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosisQ27932934
Role for the silencing protein Dot1 in meiotic checkpoint controlQ27935732
The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18Q27936359
TRF2 Protects Human Telomeres from End-to-End FusionsQ28111898
The human and mouse replication-dependent histone genesQ28212439
Genome instability: a mechanistic view of its causes and consequencesQ28266306
Strand-Specific Postreplicative Processing of Mammalian TelomeresQ28315729
The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structureQ28473586
A versatile viral system for expression and depletion of proteins in mammalian cellsQ28475909
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeastQ29617217
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expressionQ29619380
Gene silencing: trans-histone regulatory pathway in chromatinQ30309681
Chromosomes and expression in human testicular germ-cell tumors: insight into their cell of origin and pathogenesis.Q33301252
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stabilityQ33489221
A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaksQ33859669
Increased risk of testicular germ cell cancer among infertile menQ33897474
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.Q34133875
Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.Q34218130
Deficiency in Bre1 Impairs Homologous Recombination Repair and Cell Cycle Checkpoint Response to Radiation Damage in Mammalian CellsQ34332401
Telomere position effect and silencing of transgenes near telomeres in the mouse.Q34519679
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migrationQ34549885
An oncogene-induced DNA damage model for cancer developmentQ34759268
Telomere dysfunction as a cause of genomic instability in Werner syndromeQ35629126
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaksQ36095690
Cotranscriptional processes and their influence on genome stability.Q36538957
Histone ubiquitylation and the regulation of transcriptionQ36566101
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomesQ36775252
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylationQ36824900
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumorsQ37089250
What histone code for DNA repair?Q37093152
Risk of testicular cancer in men with abnormal semen characteristics: cohort studyQ37357651
The role of RAD6 in recombinational repair, checkpoints and meiosis via histone modificationQ37397286
Set1 is required for meiotic S-phase onset, double-strand break formation and middle gene expressionQ38342660
Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.Q39583815
Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombeQ41848290
Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeastQ42268671
A new mouse tumor model system (RIF-1) for comparison of end-point studiesQ42799818
Increased incidence of testicular cancer in men presenting with infertility and abnormal semen analysisQ43874423
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.Q44094473
ES cell cycle progression and differentiation require the action of the histone methyltransferase Dot1L.Q45959315
Pol eta is required for DNA replication during nucleotide deprivation by hydroxyureaQ46406774
Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosisQ46984194
Pathobiology of testicular germ cell tumors: views and news.Q53953816
Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaksQ64388968
Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumorsQ82310193
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)2111-2119
P577publication date2012-02-21
P1433published inCancer ResearchQ326097
P1476titleDeficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability
P478volume72

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cites work (P2860)
Q36086940A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.
Q39042489Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions
Q57285706Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks
Q42635236Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression
Q48331605Centromeric histone H2B monoubiquitination promotes noncoding transcription and chromatin integrity
Q60960280Chromatin as a Platform for Modulating the Replication Stress Response
Q36818314Chromatin: receiver and quarterback for cellular signals
Q64245517Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer
Q90575977Dissenting degradation: Deubiquitinases in cell cycle and cancer
Q58104057Dynamin impacts homology-directed repair and breast cancer response to chemotherapy
Q90622304Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer
Q53026880Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress.
Q35806891Epigenetic Alterations in Fanconi Anaemia: Role in Pathophysiology and Therapeutic Potential.
Q102075453Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis
Q36742165Functional analysis of Bre1p, an E3 ligase for histone H2B ubiquitylation, in regulation of RNA polymerase II association with active genes and transcription in vivo
Q34415765Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip
Q92646507High RNF40 expression indicates poor prognosis of hepatocellular carcinoma
Q26825542Histone H2B monoubiquitination: roles to play in human malignancy
Q36673042Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
Q37705706Histone modifications as regulators of life and death in Saccharomyces cerevisiae
Q89449561Identification of eQTLs and sQTLs associated with meat quality in beef
Q47576205Loss of H2B monoubiquitination is associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma
Q40564558Loss of H2Bub1 Expression is Linked to Poor Prognosis in Nodal Negative Colorectal Cancers
Q33691010Mechanisms of genome instability induced by RNA-processing defects
Q35692574Microarray Analysis Reveals Potential Biological Functions of Histone H2B Monoubiquitination
Q38926201Mitotic accumulation of dimethylated lysine 79 of histone H3 is important for maintaining genome integrity during mitosis in human cells
Q21144865Out of balance: R-loops in human disease
Q39347268Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function
Q38947687R Loops and Links to Human Disease
Q38586926R loops: new modulators of genome dynamics and function
Q36235507R-loops and genomic instability in Bre1 (RNF20/40)-deficient cells
Q90049745RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration
Q36599713RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer
Q36029959RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation
Q42505152RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer
Q64226561RNF20/40-mediated eEF1BδL monoubiquitylation stimulates transcription of heat shock-responsive genes
Q21129305Radiation-induced alterations in histone modification patterns and their potential impact on short-term radiation effects
Q26785908Replication Stress: A Lifetime of Epigenetic Change
Q64389423Role of RNF20 in cancer development and progression - a comprehensive review
Q28082525Snaps and mends: DNA breaks and chromosomal translocations
Q33940735Sus1p facilitates pre-initiation complex formation at the SAGA-regulated genes independently of histone H2B de-ubiquitylation
Q47231034Testicular cancer from diagnosis to epigenetic factors
Q38734927The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.
Q92446155The Role of Ubiquitination in Regulating Embryonic Stem Cell Maintenance and Cancer Development
Q37517626The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics
Q38008101The enigmatic role of H2Bub1 in cancer
Q100723190The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis
Q37692579The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle
Q39043059The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination
Q38241688The potential role of O-GlcNAc modification in cancer epigenetics.
Q36627930The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.
Q45304107Transcriptional stimulatory and repressive functions of histone H2B ubiquitin ligase
Q37223043Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.
Q61813359Writing Histone Monoubiquitination in Human Malignancy-The Role of RING Finger E3 Ubiquitin Ligases
Q47134084let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery

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