Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways

scientific article published on 5 August 2015

Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1033699H
P356DOI10.1371/JOURNAL.PONE.0133699
P932PMC publication ID4526660
P698PubMed publication ID26244501
P5875ResearchGate publication ID280869231

P50authorHung-Chuan ChiuQ59686909
P2093author name stringTsai-Ling Liao
Hung-Jen Liu
Kuo-Pin Chuang
Wei-Ru Huang
Wing-Ling Shih
P2860cites workAFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1Q22254000
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradationQ24290417
Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein exportQ24292285
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTENQ24292919
Ubiquitination regulates PTEN nuclear import and tumor suppressionQ24292946
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basketQ24298298
Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.Q24298502
Rak functions as a tumor suppressor by regulating PTEN protein stability and functionQ24312999
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2Q24561705
The first 30 years of p53: growing ever more complexQ24645732
A jumbo problem: mapping the structure and functions of the nuclear pore complexQ27013694
Activation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replicationQ27470019
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BQ27860731
TOR signaling in growth and metabolismQ27860757
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signallingQ28131740
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberinQ28217173
Defining the role of mTOR in cancerQ28235431
Retardation of cell growth by avian reovirus p17 through the activation of p53 pathwayQ28270765
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localizationQ28290083
Enhanced phosphorylation of p53 by ATM in response to DNA damageQ28609838
Regulation of PTEN transcription by p53Q28646911
Proteasome inhibition reduces avian reovirus replication and apoptosis induction in cultured cellsQ39985514
Infectious tenosynovitis (viral arthritis): influence of maternal antibodies on the development of tenosynovitis lesions after experimental infection by day-old chickens with tenosynovitis virusQ40025149
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.Q40054340
Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1.Q40088642
A new class of fusion-associated small transmembrane (FAST) proteins encoded by the non-enveloped fusogenic reovirusesQ40387199
Avian reovirus sigmaC protein induces apoptosis in cultured cellsQ40576362
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.Q40587498
The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathwayQ40594961
Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myelomaQ40702649
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiationQ40747424
The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascadeQ40816601
The second open reading frame of the avian reovirus S1 gene encodes a transcription-dependent and CRM1-independent nucleocytoplasmic shuttling protein.Q40976700
Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cellsQ41407134
Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A.Q42046251
AMP-activated protein kinase facilitates avian reovirus to induce mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 3/6 signalling that is beneficial for virus replicationQ43298123
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signallingQ43848062
Identification and Serological Differentiation of Several Reovirus Strains Isolated from Chickens with Suspected Malabsorption SyndromeQ45118134
Avian reovirus influences phosphorylation of several factors involved in host protein translation including eukaryotic translation elongation factor 2 (eEF2) in Vero cells.Q46030357
Modification of late membrane permeability in avian reovirus-infected cells: viroporin activity of the S1-encoded nonstructural p10 protein.Q50584889
One-thousand-and-one substrates of protein kinase CK2?Q29615345
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayQ29616144
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progressionQ29617473
Nucleotide sequence analysis of human tpr cDNA clonesQ31121814
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cellsQ32084034
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stabilityQ33706377
How do small GTPase signal transduction pathways regulate cell cycle entry?Q33796334
Rb function in cell-cycle regulation and apoptosisQ33900128
Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cellsQ33979961
Paradoxical suppression of cellular senescence by p53Q34006762
Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt.Q34336521
Sequential partially overlapping gene arrangement in the tricistronic S1 genome segments of avian reovirus and Nelson Bay reovirus: implications for translation initiationQ34357784
The p17 nonstructural protein of avian reovirus triggers autophagy enhancing virus replication via activation of phosphatase and tensin deleted on chromosome 10 (PTEN) and AMP-activated protein kinase (AMPK), as well as dsRNA-dependent protein kinasQ34509319
Tricine-SDS-PAGE.Q34615345
Awakening guardian angels: drugging the p53 pathwayQ35014385
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathwaysQ36384266
Regulation of autophagy by nucleoporin Tpr.Q36410559
Transcriptional regulation by p53: one protein, many possibilitiesQ36436698
Dynamic nuclear pore complexes: life on the edge.Q36508009
From Tpr-Met to Met, tumorigenesis and tubes.Q36745364
The nuclear affairs of PTEN.Q37063858
Nucleocytoplasmic transport of proteinsQ37087415
Understanding PTEN regulation: PIP2, polarity and protein stabilityQ37270444
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophagesQ37280434
PI3K-Akt signaling and viral infectionQ37355200
Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasisQ37411011
Divergent roles of autophagy in virus infectionQ37679218
Evidence for the multimeric nature and cell binding ability of avian reovirus sigma 3 proteinQ38357153
The RhoA-ROCK-PTEN pathway as a molecular switch for anchorage dependent cell behaviorQ39412541
Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cellsQ39460733
Loss-of-function genetics in mammalian cells: the p53 tumor suppressor modelQ39542680
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescenceQ39845659
A role for autophagolysosomes in dengue virus 3 production in HepG2 cellsQ39876782
Growth stimulation leads to cellular senescence when the cell cycle is blockedQ39925937
p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation.Q53554846
Differential regulation of Akt/protein kinase B isoforms during cell cycle progressionQ60155825
PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathwayQ74404969
Activation of small GTPases RhoA and Rac1 is required for avian reovirus p10-induced syncytium formationQ81606835
Modulation of p53 by mitogen-activated protein kinase pathways and protein kinase C delta during avian reovirus S1133-induced apoptosisQ83235743
Avian reovirus S1133-induced DNA damage signaling and subsequent apoptosis in cultured cells and in chickensQ84584250
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectReovirusQ69812835
P304page(s)e0133699
P577publication date2015-08-05
P1433published inPLOS OneQ564954
P1476titleAvian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways
P478volume10

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Q91697506Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis
Q41348469Classical swine fever virus Shimen infection increases p53 signaling to promote cell cycle arrest in porcine alveolar macrophages
Q43237479Correction: Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways
Q36686335Dissection and integration of the autophagy signaling network initiated by bluetongue virus infection: crucial candidates ERK1/2, Akt and AMPK.
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Q59358650Mechanistic insights into avian reovirus p17-modulated suppression of cell cycle CDK-cyclin complexes and enhancement of p53 and cyclin H interaction
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Q92987978The multifarious roles of heterogeneous ribonucleoprotein A1 in viral infections

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