From static structure to living protein: computational analysis of cytochrome c oxidase main-chain flexibility

scientific article published in May 2012

From static structure to living protein: computational analysis of cytochrome c oxidase main-chain flexibility is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BPJ.2012.03.040
P932PMC publication ID3341565
P698PubMed publication ID22824280
P5875ResearchGate publication ID229552096

P2093author name stringShelagh Ferguson-Miller
Leslie A Kuhn
Leann Buhrow
P2860cites workA molecular dynamics study of water chain formation in the proton-conducting K channel of cytochrome c oxidaseQ45202552
Microscopic pKa analysis of Glu286 in cytochrome c oxidase (Rhodobacter sphaeroides): toward a calibrated molecular modelQ46109336
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Binding of O(2) and its reduction are both retarded by replacement of valine 279 by isoleucine in cytochrome c oxidase from Paracoccus denitrificansQ73829091
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Dynamics of heteropentameric nicotinic acetylcholine receptor: implications of the gating mechanismQ80424010
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Energy transduction: proton transfer through the respiratory complexesQ22255654
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Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragmentQ24657440
ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structuresQ24812180
The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroidesQ27639427
Crystallographic studies of Xe and Kr binding within the large internal cavity of cytochrome ba3 from Thermus thermophilus: structural analysis and role of oxygen transport channels in the heme-Cu oxidasesQ27650196
High resolution crystal structure of Paracoccus denitrificans cytochrome c oxidase: new insights into the active site and the proton transfer pathwaysQ27654918
Redox-Dependent Conformational Changes in Cytochrome c Oxidase Suggest a Gating Mechanism for Proton UptakeQ27655301
Crystallographic and online spectral evidence for role of conformational change and conserved water in cytochrome oxidase proton pumpQ27666469
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Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidaseQ30357524
Predicting conserved water-mediated and polar ligand interactions in proteins using a K-nearest-neighbors genetic algorithm.Q30426491
Cytochrome c oxidase: exciting progress and remaining mysteriesQ33576115
Decoupling mutations in the D-channel of the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides suggest that a continuous hydrogen-bonded chain of waters is essential for proton pumpingQ33875968
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanismQ34190634
The normal modes of the gramicidin-A dimer channelQ34260066
Common mechanism of pore opening shared by five different potassium channelsQ34600882
Possible proton relay pathways in cytochrome c oxidaseQ34636365
Cytochrome c oxidase deficiency: patients and animal modelsQ34659040
Impaired proton pumping in cytochrome c oxidase upon structural alteration of the D pathwayQ35022843
Mapping protein dynamics in catalytic intermediates of the redox-driven proton pump cytochrome c oxidaseQ35108247
A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidaseQ37117512
Harmonic dynamics of proteins: normal modes and fluctuations in bovine pancreatic trypsin inhibitorQ37549050
Definition of the interaction domain for cytochrome c on cytochrome c oxidase. III. Prediction of the docked complex by a complete, systematic searchQ41710393
Calculated proton uptake on anaerobic reduction of cytochrome C oxidase: is the reaction electroneutral?Q41788669
2D-SEIRA spectroscopy to highlight conformational changes of the cytochrome c oxidase induced by direct electron transferQ41909897
A chemically explicit model for the mechanism of proton pumping in heme-copper oxidasesQ41948621
Dynamical properties of the MscL of Escherichia coli: a normal mode analysisQ42608069
Multiconformation continuum electrostatics analysis of the effects of a buried Asp introduced near heme a in Rhodobacter sphaeroides cytochrome c oxidaseQ42690205
Buried waters and internal cavities in monomeric proteinsQ42844341
Molecular dynamics simulation of water in cytochrome c oxidase reveals two water exit pathways and the mechanism of transportQ42975917
A novel cryoprotection scheme for enhancing the diffraction of crystals of recombinant cytochrome ba3 oxidase from Thermus thermophilusQ43017224
Protein flexibility predictions using graph theoryQ43629667
The entry point of the K-proton-transfer pathway in cytochrome c oxidaseQ44114463
Water-gated mechanism of proton translocation by cytochrome c oxidaseQ44452845
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcomputational biologyQ177005
P304page(s)2158-2166
P577publication date2012-05-01
P1433published inBiophysical JournalQ2032955
P1476titleFrom static structure to living protein: computational analysis of cytochrome c oxidase main-chain flexibility
P478volume102

Reverse relations

cites work (P2860)
Q38318210A conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase
Q26767379Biomimetic Membranes for Multi-Redox Center Proteins
Q46167956Biophysical Journal 60 Years after Hodgkin-Huxley
Q37384663Computational prediction and in vitro analysis of potential physiological ligands of the bile acid binding site in cytochrome c oxidase
Q34435534Conserved glycine 232 in the ligand channel of ba3 cytochrome oxidase from Thermus thermophilus
Q28542472Exploring O2 diffusion in A-type cytochrome c oxidases: molecular dynamics simulations uncover two alternative channels towards the binuclear site
Q30357691Phase-sensitive detection in modulation excitation spectroscopy applied to potential induced electron transfer in cytochrome c oxidase.
Q28596823Revisiting Kadenbach: Electron flux rate through cytochrome c-oxidase determines the ATP-inhibitory effect and subsequent production of ROS
Q47914262Role of conformational change and K-path ligands in controlling cytochrome c oxidase activity.
Q42066097Structural and functional assessment of perilipin 2 lipid binding domain(s).
Q41854024Time-resolved surface-enhanced IR-absorption spectroscopy of direct electron transfer to cytochrome c oxidase from R. sphaeroides
Q37444435Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?

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