A conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase

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A conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase is …
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scholarly articleQ13442814

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P356DOI10.1021/BI3014505
P932PMC publication ID3622084
P698PubMed publication ID23351100

P2093author name stringJian Liu
Carrie Hiser
Shelagh Ferguson-Miller
Leann Buhrow
Leslie Kuhn
P2860cites workConSurf 2005: the projection of evolutionary conservation scores of residues on protein structuresQ24812180
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A pi-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase.Q27648381
Crystallographic Analysis of Human Serum Albumin Complexed with 4Z,15E-Bilirubin-IXαQ27651037
A Conserved Steroid Binding Site in Cytochrome c Oxidase † ‡Q27651880
High resolution crystal structure of Paracoccus denitrificans cytochrome c oxidase: new insights into the active site and the proton transfer pathwaysQ27654918
Redox-Dependent Conformational Changes in Cytochrome c Oxidase Suggest a Gating Mechanism for Proton UptakeQ27655301
Crystallographic and online spectral evidence for role of conformational change and conserved water in cytochrome oxidase proton pumpQ27666469
Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1Q27673724
The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 AQ27732721
The metabolism of phytanic acid and pristanic acid in man: a reviewQ28289063
Distilling the essential features of a protein surface for improving protein-ligand docking, scoring, and virtual screening.Q30333075
Cytochrome aa3 of Rhodobacter sphaeroides as a model for mitochondrial cytochrome c oxidase. Purification, kinetics, proton pumping, and spectral analysisQ67866473
Effect of changing the detergent bound to bovine cytochrome c oxidase upon its individual electron-transfer stepsQ68459148
Regulation of the H+/e- stoichiometry of cytochrome c oxidase from bovine heart by intramitochondrial ATP/ADP ratiosQ71034269
Fatty acids stimulate activity and restore respiratory control in a proton channel mutant of cytochrome c oxidaseQ71548745
Conditions for optimal electron transfer activity of cytochrome c oxidase isolated from beef heart mitochondriaQ72855022
Glutamate-89 in subunit II of cytochrome bo3 from Escherichia coli is required for the function of the heme-copper oxidaseQ73187798
The ratio between the fast and slow forms of bovine cytochrome c oxidase is changed by cholate or nucleotides bound to the cholate-binding site close to the cytochrome a3/CuB binuclear centreQ73189136
ATP and ADP bind to cytochrome c oxidase and regulate its activityQ73826834
Mechanism of inhibition of electron transfer by amino acid replacement K362M in a proton channel of Rhodobacter sphaeroides cytochrome c oxidaseQ74252486
Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroidsQ74578194
Studies of the electrontransfer system. 48. Phospholipid requirements in cytochrome oxidaseQ76454850
Screening a peptidyl database for potential ligands to proteins with side-chain flexibilityQ77314228
Glucocorticoids decrease cytochrome c oxidase activity of isolated rat kidney mitochondriaQ77357136
Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidaseQ30357524
Conformer generation with OMEGA: algorithm and validation using high quality structures from the Protein Databank and Cambridge Structural DatabaseQ30494222
C-terminal truncation and histidine-tagging of cytochrome c oxidase subunit II reveals the native processing site, shows involvement of the C-terminus in cytochrome c binding, and improves the assay for proton pumpingQ30666492
Structure and function of mitochondrial supercomplexesQ33520869
Effect of bilirubin on cytochrome c oxidase activity of mitochondria from mouse brain and liverQ33599258
Cell respiration is controlled by ATP, an allosteric inhibitor of cytochrome-c oxidaseQ34065459
3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP.Q34066184
Alkyl glycoside detergents: a simpler synthesis and their effects on kinetic and physical properties of cytochrome c oxidase.Q34251825
Cytochrome C oxidase and the regulation of oxidative phosphorylation.Q34518288
Mapping protein dynamics in catalytic intermediates of the redox-driven proton pump cytochrome c oxidaseQ35108247
Intrinsic and extrinsic uncoupling of oxidative phosphorylationQ35135529
From static structure to living protein: computational analysis of cytochrome c oxidase main-chain flexibilityQ35926223
Biological effects of 3,5-diiodothyronine (T(2)).Q36088199
The roles of the two proton input channels in cytochrome c oxidase from Rhodobacter sphaeroides probed by the effects of site-directed mutations on time-resolved electrogenic intraprotein proton transferQ36550302
Crystallographic location and mutational analysis of Zn and Cd inhibitory sites and role of lipidic carboxylates in rescuing proton path mutants in cytochrome c oxidaseQ36663543
Conserved lipid-binding sites in membrane proteins: a focus on cytochrome c oxidaseQ36673610
Phytanic acid--an overlooked bioactive fatty acid in dairy fat?Q37730200
Gating and regulation of the cytochrome c oxidase proton pump.Q37968798
Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40.Q39542972
Studies on cytochrome oxidase. Interactions of the cytochrome oxidase protein with phospholipids and cytochrome cQ39918467
Lipid requirements for cytochrome c oxidase activityQ40116272
A chemically explicit model for the mechanism of proton pumping in heme-copper oxidasesQ41948621
CHOBIMALT: a cholesterol-based detergentQ42267481
Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexesQ42406378
A role for the protein in internal electron transfer to the catalytic center of cytochrome c oxidaseQ42672898
In vitro evidence that phytanic acid compromises Na(+),K(+)-ATPase activity and the electron flow through the respiratory chain in brain cortex from young ratsQ42972631
Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid.Q43264388
Protein flexibility predictions using graph theoryQ43629667
The entry point of the K-proton-transfer pathway in cytochrome c oxidaseQ44114463
Substitutions for glutamate 101 in subunit II of cytochrome c oxidase from Rhodobacter sphaeroides result in blocking the proton-conducting K-channelQ44309829
The decline of molecular activity of cytochrome oxidase during purificationQ44466884
Retinoic acid treatment increases lipid oxidation capacity in skeletal muscle of miceQ46779275
Exploring the inhibitor binding pocket of respiratory complex I.Q46848558
Biochemical and biophysical studies on cytochrome c oxidase. XIII. Effect of cholate on the enzymic activity.Q47836293
Regulation of energy transduction and electron transfer in cytochrome c oxidase by adenine nucleotidesQ47983392
The functional and physical form of mammalian cytochrome c oxidase determined by gel filtration, radiation inactivation, and sedimentation equilibrium analysisQ48600705
Regulation of the energy coupling in mitochondria by some steroid and thyroid hormones.Q50974300
Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase).Q52567911
The stoichiometry and absorption spectra of components a and a-3 in cytochrome c oxidase.Q54093967
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectligand bindingQ61659151
P304page(s)1385-1396
P577publication date2013-02-12
P1433published inBiochemistryQ764876
P1476titleA conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase
P478volume52

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cites work (P2860)
Q37130302Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides
Q37384663Computational prediction and in vitro analysis of potential physiological ligands of the bile acid binding site in cytochrome c oxidase
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Q90167257Monomeric structure of an active form of bovine cytochrome c oxidase
Q47914262Role of conformational change and K-path ligands in controlling cytochrome c oxidase activity.
Q52601488The K-path entrance in cytochrome c oxidase is defined by mutation of E101 and controlled by an adjacent ligand binding domain.
Q21132337The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases
Q37444435Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?