The role of IL-27 in the development of T-cell responses during parasitic infections

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The role of IL-27 in the development of T-cell responses during parasitic infections is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.0105-2896.2004.00213.X
P698PubMed publication ID15546389
P5875ResearchGate publication ID8181428

P50authorAlejandro VillarinoQ43171336
P2093author name stringDavid Artis
Christopher A Hunter
Phillip Scott
P2860cites workA novel transcription factor, T-bet, directs Th1 lineage commitmentQ22253874
Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 CommitmentQ24301442
WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27Q24307411
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cellsQ28214882
Development of Th1-type immune responses requires the type I cytokine receptor TCCRQ28591931
The lineage decisions of helper T cellsQ29614841
STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gammaQ33887011
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cellsQ33952975
Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient miceQ34430392
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunityQ34529549
The immunology of susceptibility and resistance to Leishmania major in miceQ34988360
The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responsesQ35582560
Understanding the pro- and anti-inflammatory properties of IL-27.Q35829406
Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanismQ36350176
Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigensQ36355614
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsetsQ36355870
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytesQ36356764
Recombinant interleukin 12 cures mice infected with Leishmania majorQ36361742
Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune responseQ36361808
Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondiiQ36367127
Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantationQ36369420
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant miceQ40705435
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cellsQ40757721
Toxoplasmosis in patients with cancerQ40797537
Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondiiQ40860927
Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clonesQ42070272
IL-4-deficient Balb/c mice resist infection with Leishmania majorQ42943751
IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12.Q43466126
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine productionQ44721986
Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitisQ44788662
In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) settingQ45069275
Frequent expression of the Epstein-Barr virus (EBV)-induced gene, EBI3, an IL-12 p40-related cytokine, in Hodgkin and Reed-Sternberg cellsQ45730504
WSX-1: a key role in induction of chronic intestinal nematode infectionQ47371263
The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infectionQ47388000
Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection.Q47810571
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.Q51065721
P304page(s)106-114
P577publication date2004-12-01
P1433published inImmunological ReviewsQ15724582
P1476titleThe role of IL-27 in the development of T-cell responses during parasitic infections
P478volume202

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cites work (P2860)
Q98177694C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection
Q43605525CD4+ Foxp3+ regulatory T cells mediate Toxoplasma gondii-induced T-cell suppression through an IL-2-related mechanism but independently of IL-10.
Q37471208Cigarette Smoke Induction of Interleukin-27/WSX-1 Regulates the Differentiation of Th1 and Th17 Cells in a Smoking Mouse Model of Emphysema
Q34472010Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors
Q39945236Cytokine Signatures Associated With Early Onset, Active Lesions and Late Cicatricial Events of Retinochoroidal Commitment in Infants With Congenital Toxoplasmosis.
Q41963983Disruption of interleukin-27 signaling results in impaired gamma interferon production but does not significantly affect immunopathology in murine schistosome infection
Q38520459Distinct transcriptional profiles characterize oral epithelium-microbiota interactions
Q33670036IL-12 and IL-27 sequential gene therapy via intramuscular electroporation delivery for eliminating distal aggressive tumors.
Q27335548IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection
Q36370603IL-23 and IL-27 Levels in Macrophages Collected from Peripheral Blood of Patients with Healing Vs Non-Healing Form of Cutaneous Leishmaniasis
Q35072420IL-27 and type 2 immunity in asthmatic patients: association with severity, CXCL9, and signal transducer and activator of transcription signaling
Q54358247IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10.
Q34488727IL-27-induced modulation of autoimmunity and its therapeutic potential
Q41313244Interferon Gamma in African Trypanosome Infections: Friends or Foes?
Q34681102Macrophage migration inhibitory factor contributes to host defense against acute Trypanosoma cruzi infection.
Q38962452Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review
Q47992175Proinflammatory and regulatory cytokines and chemokines in infants with uncomplicated and severe Plasmodium falciparum malaria
Q42129243Regulation of defense responses against protozoan infection by interleukin-27 and related cytokines
Q36481079STAT3: a potential therapeutic target in dendritic cells for the induction of transplant tolerance
Q41641061Selective depletion of CD11c+ CD11b+ dendritic cells partially abrogates tolerogenic effects of intravenous MOG in murine EAE.
Q34482169Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27
Q36730742Synergistic enhancement of cellular immune responses by the novel Toll receptor 7/8 agonist 3M-007 and interferon-γ: implications for therapy of cutaneous T-cell lymphoma
Q36642440T Cell Vaccinology: Beyond the Reflection of Infectious Responses
Q37747271Thymic DCs derived IL-27 regulates the final maturation of CD4(+) SP thymocytes
Q35148364Transcriptional suppression of IL-27 production by Mycobacterium tuberculosis-activated p38 MAPK via inhibition of AP-1 binding
Q34157182Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.
Q36437505What makes a good anti-inflammatory drug target?

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