STAT3: a potential therapeutic target in dendritic cells for the induction of transplant tolerance

scientific article

STAT3: a potential therapeutic target in dendritic cells for the induction of transplant tolerance is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1517/14728222.10.3.459
P698PubMed publication ID16706685
P5875ResearchGate publication ID7074333

P2093author name stringBeverly E Barton
P2860cites workHexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complexQ24306425
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayQ24531184
Dendritic cells and the control of immunityQ27860918
Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cellsQ28143456
Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cellsQ28204912
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130Q28211408
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor componentsQ28257845
Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cellsQ28592531
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6Q28637521
Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activationQ28637692
IDO expression by dendritic cells: tolerance and tryptophan catabolismQ29614752
Tolerogenic dendritic cellsQ29618755
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.Q33892268
The Jak-STAT pathwayQ33899139
Regulatory activity of autocrine IL-10 on dendritic cell functionsQ33938563
Cytokine signaling in 2002: new surprises in the Jak/Stat pathwayQ34126053
Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3.Q34248349
Dendritic cells giveth and taketh awayQ56903003
Interleukin 6 inhibits delayed-type hypersensitivity and the development of adjuvant arthritisQ68007067
Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving ratsQ69840216
A common nuclear signal transduction pathway activated by growth factor and cytokine receptorsQ70476706
Pharmacogenomic analysis of rhIL-11 treatment in the HLA-B27 rat model of inflammatory bowel diseaseQ73107327
Subcutaneous or oral administration of rhIL-11 modulated the contact hypersensitivity responseQ73246658
Matching SOCS with functionQ73451243
WSX-1 is required for the initiation of Th1 responses and resistance to L. major infectionQ74840049
Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shockQ77657683
Beta 2-microglobulin as a negative regulator of the immune system: high concentrations of the protein inhibit in vitro generation of functional dendritic cellsQ78806350
The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunityQ80884527
IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cellsQ81476292
The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosisQ81482647
Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1)Q81512203
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptorQ81749177
Bow to your partner for signalingQ81810921
Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathwayQ34314210
Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromesQ34440657
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activityQ34532143
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunityQ34762373
The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responsesQ35582560
Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes.Q35835489
The role of IL-27 in the development of T-cell responses during parasitic infectionsQ35951809
IL-6 transsignaling: the in vivo consequencesQ36116485
Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infectionQ36257846
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritisQ36371158
A defect in tryptophan catabolism impairs tolerance in nonobese diabetic miceQ36376640
Reflections on STAT3, STAT5, and STAT6 as fat STATsQ37508544
Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signalingQ38319700
SOCS3 regulates the plasticity of gp130 signalingQ38354507
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient miceQ39750347
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responsesQ39797207
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunityQ40351340
Activation of dendritic cells via inhibition of Jak2/STAT3 signalingQ40370364
Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27.Q40395233
Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130.Q40415081
PIASy-deficient mice display modest defects in IFN and Wnt signalingQ40495312
Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer.Q40605195
Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell divisionQ40686234
STAT3 is required for the gp130-mediated full activation of the c-myc geneQ42753357
Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in miceQ44088495
Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenaseQ44135171
T cell apoptosis by tryptophan catabolismQ44137068
Protective effect of anti-interleukin (IL)-6 antibody against endotoxin, associated with paradoxically increased IL-6 levelsQ44301484
A critical role for Stat3 signaling in immune toleranceQ44589709
Oral Treatment with Recombinant Human Interleukin-11 Improves Mucosal Transport in the Colon of Human Leukocyte Antigen-B27 Transgenic RatsQ44625339
Modulation of tryptophan catabolism by regulatory T cells.Q44632333
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine productionQ44721986
T cell apoptosis by kynurenines.Q44943853
Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in ratsQ45098707
Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog.Q45110145
Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant.Q46499878
A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligationQ46557704
Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritisQ47685842
Leukemia inhibitory factor is linked to regulatory transplantation tolerance.Q50774069
STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells.Q50799062
Are dendritic cells afraid of commitment?Q50986652
STAT3 is required for Flt3L-dependent dendritic cell differentiation.Q51012505
The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function.Q52046758
IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation.Q53634876
WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation.Q53674763
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)459-470
P577publication date2006-06-01
P1433published inExpert Opinion on Therapeutic TargetsQ5421214
P1476titleSTAT3: a potential therapeutic target in dendritic cells for the induction of transplant tolerance
P478volume10

Reverse relations

cites work (P2860)
Q47865606Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans
Q33581824Cannabinoids Delta(9)-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells
Q47884713Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3.
Q37417083Expression and function of immunoglobulin-like transcripts on tolerogenic dendritic cells
Q50871361Extracellular Hsp70 inhibits pro-inflammatory cytokine production by IL-10 driven down-regulation of C/EBPβ and C/EBPδ.
Q33336590Generation of a novel regulatory NK cell subset from peripheral blood CD34+ progenitors promoted by membrane-bound IL-15
Q50034338Genome-Wide STAT3 Binding Analysis after Histone Deacetylase Inhibition Reveals Novel Target Genes in Dendritic Cells.
Q35016985HDAC inhibition and graft versus host disease
Q57821146Interferon-α Up-Regulates the Expression of PD-L1 Molecules on Immune Cells Through STAT3 and p38 Signaling
Q43239054Intranasally delivered siRNA targeting PI3K/Akt/mTOR inflammatory pathways protects from aspergillosis.
Q44603812Latency-associated protein Acr1 impairs dendritic cell maturation and functionality: a possible mechanism of immune evasion by Mycobacterium tuberculosis
Q24321398Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway
Q54617418PD-L1 expression on tolerogenic APCs is controlled by STAT-3.
Q38265472STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia
Q90540850Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
Q33715925Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cells
Q42146676The anti-inflammatory mechanisms of Hsp70

Search more.