Sex hormone-binding globulin and type 2 diabetes mellitus

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Sex hormone-binding globulin and type 2 diabetes mellitus is …
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scholarly articleQ13442814

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P356DOI10.1016/J.TEM.2011.09.005
P932PMC publication ID3351377
P698PubMed publication ID22047952
P5875ResearchGate publication ID51764970

P2093author name stringJerome F Strauss
John E Nestler
Edmond P Wickham
Trang N Le
P2860cites workHuman sex hormone-binding globulin gene expression- multiple promoters and complex alternative splicingQ21263035
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Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membraneQ33695110
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Sex hormone-binding globulin as an independent predictor of incident type 2 diabetes mellitus in menQ33790409
Interrelation between sex hormones and plasma sex hormone-binding globulin and hemoglobin A1c in healthy postmenopausal women.Q33894560
Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men.Q33932837
Specific steroid-binding glycoproteins of human blood plasma: novel data on their structure and functionQ34020474
Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA)n repeat element within an Alu sequenceQ34085077
Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysisQ34099068
Sex hormone-binding globulin in the human prostate is locally synthesized and may act as an autocrine/paracrine effectorQ34128778
Amino acid sequence of the sex steroid binding protein of human blood plasmaQ34183056
Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chainQ34254429
Localization of the human sex hormone-binding globulin gene (SHBG) to the short arm of chromosome 17 (17p12----p13).Q34267429
Molecular characterization of a genetic variant of the steroid hormone-binding globulin gene in heterozygous subjectsQ34308338
Relationships of circulating sex hormone-binding globulin with metabolic traits in humansQ34355301
Role of endocytosis in cellular uptake of sex steroids.Q34448507
The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAsQ34480983
Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysisQ34502187
Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in miceQ34694998
Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndromeQ34758467
Human sex hormone-binding globulin variants associated with hyperandrogenism and ovarian dysfunction.Q34790288
Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetesQ35142822
Menopausal hormone therapy and new-onset diabetes in the French Etude Epidemiologique de Femmes de la Mutuelle Générale de l'Education Nationale (E3N) cohortQ35618612
The metabolic syndrome: prevalence in worldwide populationsQ35781478
Sex hormone-binding globulin, oligomenorrhea, polycystic ovary syndrome, and childhood insulin at age 14 years predict metabolic syndrome and class III obesity at age 24 yearsQ36160966
The free hormone hypothesis. Distinction from the free hormone transport hypothesisQ36172112
Complete enzymatic deglycosylation of native sex steroid‐binding protein (SBP or SHBG) of human and rabbit plasma: Effect on the steroid‐binding activityQ36277463
Review: The role of insulin resistance in nonalcoholic fatty liver diseaseQ36591903
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survivalQ37360446
Hormonal influences on the secretion of steroid-binding proteins by a human hepatoma-derived cell lineQ72393758
Evidence that human placenta is a site of sex hormone-binding globulin gene expressionQ72550915
Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in menQ72816915
Resolution of the human sex hormone-binding globulin dimer interface and evidence for two steroid-binding sites per homodimerQ74215788
Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics Follow-up StudyQ80725936
The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal womenQ37417467
The plasma sex steroid binding protein (SBP or SHBG). A critical review of recent developments on the structure, molecular biology and functionQ37544663
Genetic variants of sex hormone-binding globulin and their biological consequencesQ37592658
Structural analyses of sex hormone-binding globulin reveal novel ligands and functionQ37596078
Study of the carbohydrate moiety of human serum sex hormone-binding globulinQ38354424
Prediction of gestational diabetes mellitus by maternal factors and biomarkers at 11 to 13 weeksQ39789690
Sex-hormone-binding globulinQ39870757
Sex hormones and metabolic syndrome in children and adolescentsQ39973538
Receptors for androgen-binding proteins: internalization and intracellular signalling.Q40455222
Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging studyQ40760488
Sex hormone binding globulin mRNA in human breast cancer: detection in cell lines and tumor samplesQ41152674
Mechanisms behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatmentQ42517050
Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men.Q43198540
Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndromeQ43249137
Population differences in the pattern of familial aggregation for sex hormone-binding globulin and its response to exercise training: the HERITAGE Family Study.Q43827205
Sex steroids and the free hormone hypothesisQ44001442
Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trialQ44269768
Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levelsQ44690322
Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men.Q44865591
A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndromeQ44942757
Sex hormone-binding globulin predicts the incidence of hyperglycemia in women: interactions with adiponectin levelsQ45015325
Heritability of plasma sex hormones and hormone binding globulin in adult male twinsQ45310736
Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblings.Q46504250
Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptorQ46513273
A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal womenQ46731592
Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years laterQ46799989
Expression of sex hormone-binding globulin (SHBG) in human granulosa-lutein cellsQ47587259
Androgens, estrogens, and second messengersQ47997949
The pituitary-gonadal axis and health in elderly men: a study of men born in 1913.Q48883715
Human variant sex hormone-binding globulin (SHBG) with an additional carbohydrate chain has a reduced clearance rate in rabbit.Q50913105
Age, genetic, and nongenetic factors influencing variation in serum sex steroids and zonal volumes of the prostate and benign prostatic hyperplasia in twins.Q50931815
Quantitative genetics of serum sex hormone-binding globulin levels in participants in the San Antonio Family Heart Study.Q50936900
Expression of sex hormone-binding globulin mRNA in uterine leiomyoma, myometrium and endometrium of human subjects.Q51033381
Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. MRFIT Research Group. Multiple Risk Factor Intervention Trial.Q51035704
Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men.Q51471439
Association of sex hormone-binding globulin and insulin resistance among Japanese-American subjects.Q51558454
Testosterone concentrations in women and men with NIDDM.Q51595541
Low sex-hormone-binding globulin concentration as independent risk factor for development of NIDDM. 12-yr follow-up of population study of women in Gothenburg, Sweden.Q51612365
Associations of endogenous testosterone and SHBG with glycated haemoglobin in middle-aged and older menQ57202665
Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndromeQ61896519
SECRETION OF TESTOSTERONE-ESTRADIOL-BINDING GLOBULIN BY A HUMAN HEPATOMA-DERIVED CELL LINEQ63533248
The relationship of sex hormones to hyperinsulinemia and hyperglycemiaQ68146316
Delineation and synthesis of the membrane receptor-binding domain of sex hormone-binding globulinQ68479872
Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactinQ69835717
Methylation analysis in glycoprotein chemistry: a comparative study of the carbohydrate structures of three hormone-binding glycoproteins from human serumQ69945592
Sex hormone-binding globulin secretion by human hepatocarcinoma cells is increased by both estrogens and androgensQ70166456
Regulation of sex hormone binding globulin (SHBG) production in Hep G2 cells by insulinQ70264202
Sex hormone-binding globulin: a marker for hyperinsulinemia and/or insulin resistance?Q70559848
Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (Hep G2) cellsQ71687663
P433issue1
P921main subjecttype 2 diabetesQ3025883
P304page(s)32-40
P577publication date2011-11-01
P1433published inTrends in Endocrinology and MetabolismQ15265727
P1476titleSex hormone-binding globulin and type 2 diabetes mellitus
P478volume23

Reverse relations

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