Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

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Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1045294653
P356DOI10.1186/1471-2202-13-33
P932PMC publication ID3352246
P698PubMed publication ID22443187
P5875ResearchGate publication ID221972001

P2093author name stringChristian Hölscher
Kerry Hunter
P2860cites workGlucagon-like peptide-1 receptor is involved in learning and neuroprotectionQ28202403
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetesQ28273497
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signallingQ28574687
Biology of incretins: GLP-1 and GIPQ29617302
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.Q34167980
Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic miceQ35180081
Neurodegenerative disorders associated with diabetes mellitusQ35791191
Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's diseaseQ36172658
Liraglutide: a new treatment for type 2 diabetesQ37431559
Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease.Q37718840
Lixisenatide for type 2 diabetes mellitusQ37851499
Glucose tolerance status and risk of dementia in the community: the Hisayama studyQ43584777
Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humansQ44178339
Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system.Q45925400
Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 miceQ46324379
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.Q48575219
The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.Q51011184
Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats.Q51040221
Hyperinsulinemia and risk of Alzheimer disease.Q51526824
Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sitesQ70905833
Entry of exendin-4 into brain is rapid but may be limited at high dosesQ73107463
Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brainQ83396445
The effect of exenatide re-exposure on safety and efficacyQ84167596
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P921main subjectblood–brain barrierQ221694
neurogenesisQ1456827
liraglutideQ2526479
P304page(s)33
P577publication date2012-03-23
P1433published inBMC NeuroscienceQ15766477
P1476titleDrugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
P478volume13

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