Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice.

scientific article published on 16 July 2015

Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JNC.13248
P698PubMed publication ID26183127

P2093author name stringYan Yang
Gang Yuan
De-Lin Ma
Wei-Jie Xu
Fu-Qiong Chen
Wen-Zhu Yue
P2860cites workGSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptidesQ28205921
Eight weeks of treatment with long-acting GLP-1 analog taspoglutide improves postprandial insulin secretion and sensitivity in metformin-treated patients with type 2 diabetes.Q51338027
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseQ29617286
Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant miceQ30419141
The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetesQ33826388
Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.Q33943081
Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3.Q34338701
Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brainQ34452590
Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse modelQ34639384
Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease.Q34655623
Tau in Alzheimer disease and related tauopathiesQ34953869
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Deficient brain insulin signalling pathway in Alzheimer's disease and diabetesQ35794263
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineQ35858095
Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesisQ35960169
Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's diseaseQ36012200
Insulin signaling and insulin resistanceQ36806238
History of medically treated diabetes and risk of Alzheimer disease in a nationwide case-control studyQ36942194
Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's diseaseQ37382673
Targeting tau protein in Alzheimer's diseaseQ37744878
Effect of intranasal insulin on cognitive function: a systematic reviewQ37967672
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Overlapped metabolic and therapeutic links between Alzheimer and diabetes.Q38046539
Alzheimer disease and diabetes mellitus: do they have anything in common?Q38102765
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Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?Q38192319
Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stressQ39083326
Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db miceQ42715172
Neurobehavioral deficits in db/db diabetic miceQ42736763
Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of ratsQ42904879
Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weightQ42936904
Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes.Q42950655
Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice.Q46396191
Detection of beta-endorphin in the cerebrospinal fluid after intrastriatal microinjection into the rat brainQ46436795
A biochemical and functional characterization of diet-induced brain insulin resistanceQ46526769
Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db miceQ46673962
Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62.Q47881193
Hyperinsulinemia in rats causes impairment of spatial memory and learning with defects in hippocampal synaptic plasticity by involvement of postsynaptic mechanismsQ48181763
Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's diseaseQ48270990
Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranesQ48703627
Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone.Q48912299
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectliraglutideQ2526479
P304page(s)301-308
P577publication date2015-07-16
P1433published inJournal of NeurochemistryQ6295643
P1476titleEarly intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice.
P478volume135

Reverse relations

cites work (P2860)
Q39270980A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies
Q90679431Antidiabetic therapies and Alzheimer disease
Q38994655Dynamics of diabetes and obesity: Epidemiological perspective
Q47217002Gelidium elegans Extract Ameliorates Type 2 Diabetes via Regulation of MAPK and PI3K/Akt Signaling
Q47161453Laminarin counteracts diet-induced obesity associated with glucagon-like peptide-1 secretion
Q64088518Liraglutide and its Neuroprotective Properties-Focus on Possible Biochemical Mechanisms in Alzheimer's Disease and Cerebral Ischemic Events
Q38668948Novel GLP-1 (Glucagon-Like Peptide-1) Analogues and Insulin in the Treatment for Alzheimer's Disease and Other Neurodegenerative Diseases
Q58795095Pin1 Modulation in Physiological Status and Neurodegeneration. Any Contribution to the Pathogenesis of Type 3 Diabetes?
Q59812434Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function
Q38926789Potential effects of current drug therapies on cognitive impairment in patients with type 2 diabetes
Q26768527The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
Q38823805Therapeutic Potential of Antidiabetic Medications in the Treatment of Cognitive Dysfunction and Dementia
Q36905790Type 2 diabetes-induced neuronal pathology in the piriform cortex of the rat is reversed by the GLP-1 receptor agonist exendin-4.

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